**Please note, these are just some of the many electives offered through the Division of Graduate Medical Sciences and BUSM that previous MSCI students have taken.

GMS CI 660 Good Clinical Practices in Clinical Research

Prereq: consent of instructor.  Introduces regulatory responsibilities of sponsors, monitors, and investigators conducting clinical trials. Practical information and exercises are designed on GCP compliance fro m an industrial perspective. Topics include: selecting qualified investigators; obtaining ethical approval for patients, and initiating sites successfully. Group discussions and guest speakers help students learn practical skills. Malikova. 4 cr, Summer II.

GMS CI 680 Ethical Issues in Clinical Research

Prereq: consent of instructor  Students examine the development and implementation of regulatory as well as ethical issues involved with conducting clinical trials. Topics covered include: protection of human subjects, privacy and confidentiality, conflicts of interest, negativity toward clinical trials, research on vulnerable subjects, genetic testing and genetic research. Also included are discussions of current ethical issues in clinical research within the media. Baedorf-Kassis, 2 cr, Spring.

GMS CI 671 Applied regression analysis with Computing

Prereq: CI 670. This course covers analytic and computational methods for modeling and regression analysis in the biomedical sciences. Emphasis is on fitting exploratory and inferential models to data in epidemiology and clinical trials. Topics include tabular and graphical summary; the linear, logistic, and Poisson regression models; the Kaplan-Meier method and Cox proportional hazards analysis; power calculation; estimation of effect size.  Analyses are presented and completed using the SAS and R software packages. Lecture and laboratory exercises are structured around worked examples from the recent biomedical literature. Evaluation is via homework assignments, a midterm examination, and a final project and presentation. Travison. 3 cr, Spring sem.

GMS CI 793 Professionalism & Thesis Development

Prereq: CI 675 & CI 790 To provide CI students with knowledge of and experience in professional standards, and (2) guidance in developing a thesis proposal and writing a masters level thesis. Topics will include professionalism & professional standards including professional communication, networking and resume and cover letter writing; formal and scientific writing skills, guidance in developing a research topic, and writing a thesis proposal and thesis.  The primary aim of this course is to help students adjust from an informal writing style to that required for scientific communication, presentations and theses. Hess Pino, 2 cr, Summer I

GMS CI 691 or 692 Directed Studies in Clinical Investigation

Directed study provides the opportunity for students to explore a special topic of interest under the direction of a MSCI faculty member.  Students may register for 2 credits of directed study by submitting a paper registration form, after the MSCI faculty member has agreed to work with the student on a specific project.  Directed studies with a non-MSCI faculty member or adjunct member must first be approved by and assigned to the Director or Assistant Director of MSCI as Faculty Sponsor.  Directed-Study-Form

GMS CI 801 or 802 Thesis Research in Clinical Investigation

Prereq: 32 credits of course work. The clinical research thesis provides a culminating experience and applies the principles and methods learned in the coursework to a real-life clinical study. To demonstrate the student’s understanding of the clinical research process from both a theoretical and a practical point of view. Hess Pino, 2 cr, variable

GMS MS 621 Bench to Bedside: Translating Biomedical Innovation from Laboratory to the Marketplace

Prereq: consent of instructor.  This course covers intellectual property, licensing, and the core aspects of planning, creating, funding, and building new entrepreneurial ventures. Cross disciplinary teams are formed to evaluate current BU translational research projects and their potential as the basis for a start-up company. Gupta 4 cr, Fall.

GMS MM 710 Molecules to Molecular Therapeutics

Prereq: consent of the instructor. This course is designed to provide instruction in all aspects of the translation of basic research observations into clinical applications, using a case study model. The first case study will focus on sickle cell anemia. Lectures will review the molecular genetics of the disease and explore animal models for study of sickle cell anemia and will include laboratory exercises as appropriate.

The course will address treatment strategies for sickle cell disease, including pharmacologic manipulation of globin gene expression, structural biology and rational drug design, and gene therapy. Additional topics related to clinical trials development will be covered including ethical issues, regulatory affairs, statistical considerations in clinical research, and outcome analysis. Required of all molecular medicine graduate students.  Seldin, Steinberg. 4 cr, Spring.

GMS AN 715 Professional Skills for Students in the Biomedical Sciences

Prereq: consent of instructor.  This course discusses many of the professional skills and ethical issues that are part of an academic biomedical career. Some of the topics include funding mechanisms, determination of authorship, intellectual property, conflict of interest, human and animal subject protection, reviewing responsibilities and mentoring. Zucker. 2 cr, Spring.

GMS PM 730 Introduction to Medical Pharmacology

Prereq: consent of instructor.  Principles of pharmacology are covered and several major classes of therapeutic agents, with attention to their mechanisms of action. Issues of current and future concern in medical pharmacology are addressed including problems of drug abuse, the ethics of human experimentation, the pricing of new drugs, and new biotechnological approaches to drug design and development. Walsh, staff. 4 cr, Fall.

GMS PM 800 Advanced General Pharmacology

Prereq: consent of instructor.  Lectures and discussions on the major classes of pharmacologic agents, with special attetnion to molecular, cellular, and physiologial mechanisms of therapeutic effects. Boyde, staff. 2 cr, Fall.

GMS PM 881 Drug Discovery and Development

Prereq: consent of instructor. This course will address the discovery and development process for small molecule and protein drug products. Topics will include target identification and validation, lead optimization and selection of drug candidates for clinical testing, and the objectives and design of clinical trials. Williams and Farb. 2 cr, Spring

SPH EP 713 Introduction to Epidemiology.

Epidemiology is a methodology that enables public health professionals to identify the determinants of health, disease and injury in human populations and provides a means of assessing the magnitude of public health problems and the success of interventions designed to control them. It is essential for understanding and solving public health problems, regardless one’s area of concentration or specialization. The goals of EP713 are to introduce the basic principles and methods of epidemiology and demonstrate their applicability to public health; to provide fundamental skills needed to interpret and critically evaluate literature relevant to public health professionals; and to provide a structured method for organizing and analyzing raw data and to enable students to interpret and communicate the results to public health professionals and to the general public. Classes generally utilize a lecture format, but lectures are interspersed with active learning exercises consisting of a mixture of in-class problems, exercises, and discussions. The course uses online and independent learning modules that will further enable students to achieve the learning objectives. LaMorte, Brogly, & Shea 3 cr. either sem.

SPH BS 775 Topics in Biostatistics

This seminar provides a platform for a variety of biostatistical topicsto be discussed at the intermediate level. Topics may include newly developed methods, or topics may consider in more depth issues that are only briefly discussed in other courses. Faculty, 4 cr.

SPH HS 806 The Biotechnology Industry

The biotechnology industry is undergoing dramatic growth, sparked by advances in genomics and proteomics. This course provides an overview of the industry, its history and relaton to pharmaceuticals and its importance to health care.

Topics include the human genome project; drug discovery and development; pharmacoeconomics, FDA regulation of drugs and biologic; venture capital and IPOs; patents and intellectual property, entrepreneurship in biotech; and a future outlook for the industry. Coit, 4 cr.

Please Note:

A wide variety of research related courses are available through the Division of Graduate  Medical Sciences (GMS  Research) and Boston University Medical Campus. The complete course catalog for the Division is available. Please be sure to consult with your adviser before registering for any elective courses.