By Dr. Valentina Sabino

Sabino V, Narayan AR, Zeric T, Steardo L, Cottone P. mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. Behav Brain Res. 2013 Mar 4; doi:pii: S0166-4328(13)00112-5. 10.1016/j.bbr.2013.02.030 [In Press]

Blasio A, Steardo L, Sabino V, Cottone P. Opioid system in the medial prefrontal cortex mediates binge-like eating. Addict Biol. 2013 Jan 24; doi: 10.1111/adb.12033. [In Press]

Sabino V, Kwak J, Rice KC, Cottone P. Pharmacological Characterization of the 20% Alcohol Intermittent Access Model in Alcohol-Preferring Rats: A Model of Binge-Like Drinking. Alcohol Clin Exp Res. 2012 Nov 5; doi: 10.1111/acer.12008 [In Press]

Cottone P, Narayan AR, Kwak J, Sabino V. The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats. Psychopharmacology (2013); 226(1): 127-38.

Cottone P, Wang X, Park J, Valenza M, Blasio A, Kwak J, Iyer MR, Steardo L, Rice KC, Hayashi T, Sabino V. Antagonism of Sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology (2012); 37(12): 2593-604.

Sabino V, Cottone P, Blasio A, Iyer M, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of Sigma Receptors Induces Binge-like Drinking in Sardinian Alcohol-Preferring Rats. Neuropsychopharmacology (2011); 36(6): 1207-18. PMC3079320.

Roberto M; Cruz MT; Gilpin NW; Sabino V; Schweitzer P; Bajo M; Cottone P; Madamba S; Stouffer DG; Zorrilla EP; Koob GF; Siggins GR; Parsons LH. CRF-induced amygdala GABA release plays a key role in alcohol dependence.Biol Psychiatry (2010); 67(9):831-9. PMC2785284.

Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf J, Fekete EM, Steardo L, Rice KC, Grigoriadis D, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proc Natl Acad Sci U S A (2009); 106(47):20016-20. PMC2785284.

Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology (2009); 205(2): 327-335. PMC2748837.

Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behav Brain Res (2009); 198(2): 472-476. PMC2667953.

Sabino V, Cottone P, Zhao Y, Iyer M, Steardo L yr, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology (2009); 34(6): 1482-93. PMC2669694.

Cottone P, Sabino V, Steardo L, Zorrilla EP. Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinology (2009); 34(1):38-49. PMC Journal – In Process.

Cottone P, Sabino V, Steardo L, Zorrilla EP. Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology (2008); 33(3):524-35. PMC Journal – In Process.

Sabino V, Cottone P, Steardo L, Schmidhammer H, Zorrilla EP. 14-methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology (2007); 192(4):537-46. PMC Journal – In Process.

Cottone P, Sabino V, Steardo L, Zorrilla EP.FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology (2007); 32(5):1069-81. PMC Journal – In Process.