2019 PhD Student Publications

Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans   Minaeva O, Hua N, Franz ES, Lupoli N, Mian AZ, Farris CW, Hildebrandt AM, Kiernan PT, Evers LE, Griffin AD, Liu X, Chancellor SE, Babcock KJ, Moncaster JA, Jara H, Alvarez VE, Huber BR, Guermazi A, Latour LL, McKee AC, Soto JA, Anderson SW, Goldstein LE. Radiology. 2019 Nov 26:190461. doi: 10.1148/radiol.2019190461. [Epub ahead of print]

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile  Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S. Ann Rheum Dis. 2019 Nov 25. pii: annrheumdis-2019-215894. doi: 10.1136/annrheumdis-2019-215894. [Epub ahead of print]

Lung CD4₊ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Mucosal Immunol. 2019 Nov 20. doi: 10.1038/s41385-019-0229-2. [Epub ahead of print]

A mutation in Hnrnph1 that decreases methamphetamine-induced reinforcement, reward, and dopamine release and increases synaptosomal hnRNP H and mitochondrial proteins Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. J Neurosci. 2019 Nov 8. pii: 1808-19. doi: 10.1523/JNEUROSCI.1808-19.2019. [Epub ahead of print]

Structure of the human metapneumovirus polymerase phosphoprotein complex  Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Nature. 2019 Nov 7. doi: 10.1038/s41586-019-1759-1.

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. Geroscience. 2019 Nov 6. doi: 10.1007/s11357-019-00115-w. [Epub ahead of print]

Cardiorespiratory fitness predicts effective connectivity between the hippocampus and default mode network nodes in young adults Kronman CA, Kern KL, Nauer RK, Dunne MF, Storer TW, Schon K. Hippocampus. 2019 Oct 24. doi: 10.1002/hipo.23169.

Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gαi₂ protein-dependent, salt-sensitive hypertension Moreira JD, Chaudhary P, Frame AA, Puleo F, Nist KM, Abkin EA, Moore TL, George JC, Wainford RD. Exp Physiol. 2019 Dec;104(12):1892-1910. doi: 10.1113/EP087924. Epub 2019 Oct 20.

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14.

Sympathetic regulation of NCC in norepinephrine-evoked salt-sensitive hypertension in Sprague-Dawley rats Frame AA, Puleo F, Kim K, Walsh KR, Faudoa E, Hoover RS, Wainford RD. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1623-F1636. doi: 10.1152/ajprenal.00264.2019. Epub 2019 Oct 14.

Why Glycosylation Matters in Building a Better Flu Vaccine  Chang D, Zaia J. Mol Cell Proteomics. 2019 Dec;18(12):2348-2358. doi: 10.1074/mcp.R119.001491. Epub 2019 Oct 11. Review.

Morphometric Biomarkers of Adolescents With Familial Risk for Alcohol Use Disorder  Maksimovskiy AL, Oot EN, Seraikas AM, Rieselbach M, Caine C, Sneider JT, Cohen-Gilbert JE, Harris SK, Nickerson LD, Rohan ML, Silveri MM. Alcohol Clin Exp Res. 2019 Nov;43(11):2354-2366. doi: 10.1111/acer.14201. Epub 2019 Oct 8.

BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response  Andrieu GP, Shafran JS, Smith CL, Belkina AC, Casey AN, Jafari N, Denis GV. Cancer Lett. 2019 Nov 28;465:45-58. doi: 10.1016/j.canlet.2019.08.013. Epub 2019 Aug 29.

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance  Panier S, Maric M, Hewitt G, Mason-Osann E, Gali H, Dai A, Labadorf A, Guervilly JH, Ruis P, Segura-Bayona S, Belan O, Marzec P, Gaillard PHL, Flynn RL, Boulton SJ. Mol Cell. 2019 Oct 3;76(1):27-43.e11. doi: 10.1016/j.molcel.2019.07.010. Epub 2019 Aug 22.

Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis  Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Free Radic Biol Med. 2019 Nov 1;143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006. Epub 2019 Aug 10.

Illuminating the Role of Vpr in HIV Infection of Myeloid Cells  Nodder SB, Gummuluru S. Front Immunol. 2019 Jul 23;10:1606. doi: 10.3389/fimmu.2019.01606. eCollection 2019. Review.

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes  Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR 4th, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Cell Metab. 2019 Sep 3;30(3):447-461.e5. doi: 10.1016/j.cmet.2019.07.004. Epub 2019 Aug 1.

Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex  Babbs RK, Beierle JA, Ruan QT, Kelliher JC, Chen MM, Feng AX, Kirkpatrick SL, Benitez FA, Rodriguez FA, Pierre JJ, Anandakumar J, Kumar V, Mulligan MK, Bryant CD. G3 (Bethesda). 2019 Sep 4;9(9):3009-3022. doi: 10.1534/g3.119.400470.

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos  Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058.

Role of Sigma Receptors in Alcohol Addiction Quadir SG, Cottone P, Sabino V. Front Pharmacol. 2019 Jun 14;10:687. doi: 10.3389/fphar.2019.00687. eCollection 2019. Review.

Pathophysiology of Concussion  Chancellor SE, Franz ES, Minaeva OV, Goldstein LE. Semin Pediatr Neurol. 2019 Jul;30:14-25. doi: 10.1016/j.spen.2019.03.004. Epub 2019 Mar 23.

Neisserial PorB immune enhancing activity and use as a vaccine adjuvant  Yuen R, Kuniholm J, Lisk C, Wetzler LM. Hum Vaccin Immunother. 2019;15(11):2778-2781. doi: 10.1080/21645515.2019.1609852. Epub 2019 May 31.

BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK  Shafran JS, Andrieu GP, Györffy B, Denis GV. Mol Cancer Res. 2019 Aug;17(8):1627-1638. doi: 10.1158/1541-7786.MCR-18-1279. Epub 2019 May 20.

The Role of Schlemm’s Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study  Lai J, Su Y, Swain DL, Huang D, Getchevski D, Gong H. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1630-1643. doi: 10.1167/iovs.18-26011.

Ebolavirus polymerase uses an unconventional genome replication mechanism  Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E  Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8535-8543. doi: 10.1073/pnas.1815745116. Epub 2019 Apr 8.

Identification of the kinase STK25 as an upstream activator of LATS signaling  Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w.

TAZ Forces Lateral Inhibition  Kern JG, Varelas X. Dev Cell. 2019 Mar 25;48(6):748-750. doi: 10.1016/j.devcel.2019.03.006.

Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes Vazquez-Mateo C, Collins J, Goldberg SJ, Lawson M, Hernandez-Escalante J, Dooms H. PLoS One. 2019 Mar 25;14(3):e0214379. doi: 10.1371/journal.pone.0214379. eCollection 2019.

Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir  Pedro KD, Henderson AJ, Agosto LM. Virus Res. 2019 May;265:115-121. doi: 10.1016/j.virusres.2019.03.014. Epub 2019 Mar 21. Review.

Rates of Chronic Medical Conditions in 1991 Gulf War Veterans Compared to the General Population Zundel CG, Krengel MH, Heeren T, Yee MK, Grasso CM, Janulewicz Lloyd PA, Coughlin SS, Sullivan K. Int J Environ Res Public Health. 2019 Mar 16;16(6). pii: E949. doi: 10.3390/ijerph16060949.

Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins  Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1061-1071. doi: 10.1016/j.bbalip.2019.03.001. Epub 2019 Mar 5.

CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features  Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. Front Genet. 2019 Feb 19;10:121. doi: 10.3389/fgene.2019.00121. eCollection 2019.

Transcriptional and Epigenetic Regulation of Microglia in Health and Disease  Yeh H, Ikezu T. Trends Mol Med. 2019 Feb;25(2):96-111. doi: 10.1016/j.molmed.2018.11.004. Epub 2018 Dec 18. Review.

Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S. Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):138-149. doi: 10.1002/ajmg.b.32691. Epub 2018 Nov 23.

TIA1 regulates the generation and response to toxic tau oligomers  Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. Acta Neuropathol. 2019 Feb;137(2):259-277. doi: 10.1007/s00401-018-1937-5. Epub 2018 Nov 21.

Quantification of discrete behavioral components of the MDS-UPDRS Brooks C, Eden G, Chang A, Demanuele C, Kelley Erb M, Shaafi Kabiri N, Moss M, Bhangu J, Thomas K. J Clin Neurosci. 2019 Mar;61:174-179. doi: 10.1016/j.jocn.2018.10.043. Epub 2018 Oct 29.

Genetic architecture of subcortical brain structures in 38,851 individuals Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, Teumer A, van der Lee SJ, Yang J, Yanek LR, Lee TV, Li S, Hu Y, Koh JY, Eicher JD, Desrivières S, Arias-Vasquez A, Chauhan G, Athanasiu L, Rentería ME, Kim S, Hoehn D, Armstrong NJ, Chen Q, Holmes AJ, den Braber A, Kloszewska I, Andersson M, Espeseth T, Grimm O, Abramovic L, Alhusaini S, Milaneschi Y, Papmeyer M, Axelsson T, Ehrlich S, Roiz-Santiañez R, Kraemer B, Håberg AK, Jones HJ, Pike GB, Stein DJ, Stevens A, Bralten J, Vernooij MW, Harris TB, Filippi I, Witte AV, Guadalupe T, Wittfeld K, Mosley TH, Becker JT, Doan NT, Hagenaars SP, Saba Y, Cuellar-Partida G, Amin N, Hilal S, Nho K, Mirza-Schreiber N, Arfanakis K, Becker DM, Ames D, Goldman AL, Lee PH, Boomsma DI, Lovestone S, Giddaluru S, Le Hellard S, Mattheisen M, Bohlken MM, Kasperaviciute D, Schmaal L, Lawrie SM, Agartz I, Walton E, Tordesillas-Gutierrez D, Davies GE, Shin J, Ipser JC, Vinke LN, Hoogman M, Jia T, Burkhardt R, Klein M, Crivello F, Janowitz D, Carmichael O, Haukvik UK, Aribisala BS, Schmidt H, Strike LT, Cheng CY, Risacher SL, Pütz B, Fleischman DA, Assareh AA, Mattay VS, Buckner RL, Mecocci P, Dale AM, Cichon S, Boks MP, Matarin M, Penninx BWJH, Calhoun VD, Chakravarty MM, Marquand AF, Macare C, Kharabian Masouleh S, Oosterlaan J, Amouyel P, Hegenscheid K, Rotter JI, Schork AJ, Liewald DCM, de Zubicaray GI, Wong TY, Shen L, Sämann PG, Brodaty H, Roffman JL, de Geus EJC, Tsolaki M, Erk S, van Eijk KR, Cavalleri GL, van der Wee NJA, McIntosh AM, Gollub RL, Bulayeva KB, Bernard M, Richards JS, Himali JJ, Loeffler M, Rommelse N, Hoffmann W, Westlye LT, Valdés Hernández MC, Hansell NK, van Erp TGM, Wolf C, Kwok JBJ, Vellas B, Heinz A, Olde Loohuis LM, Delanty N, Ho BC, Ching CRK, Shumskaya E, Singh B, Hofman A, van der Meer D, Homuth G, Psaty BM, Bastin ME, Montgomery GW, Foroud TM, Reppermund S, Hottenga JJ, Simmons A, Meyer-Lindenberg A, Cahn W, Whelan CD, van Donkelaar MMJ, Yang Q, Hosten N, Green RC, Thalamuthu A, Mohnke S, Hulshoff Pol HE, Lin H, Jack CR Jr, Schofield PR, Mühleisen TW, Maillard P, Potkin SG, Wen W, Fletcher E, Toga AW, Gruber O, Huentelman M, Davey Smith G, Launer LJ, Nyberg L, Jönsson EG, Crespo-Facorro B, Koen N, Greve DN, Uitterlinden AG, Weinberger DR, Steen VM, Fedko IO, Groenewold NA, Niessen WJ, Toro R, Tzourio C, Longstreth WT Jr, Ikram MK, Smoller JW, van Tol MJ, Sussmann JE, Paus T, Lemaître H, Schroeter ML, Mazoyer B, Andreassen OA, Holsboer F, Depondt C, Veltman DJ, Turner JA, Pausova Z, Schumann G, van Rooij D, Djurovic S, Deary IJ, McMahon KL, Müller-Myhsok B, Brouwer RM, Soininen H, Pandolfo M, Wassink TH, Cheung JW, Wolfers T, Martinot JL, Zwiers MP, Nauck M, Melle I, Martin NG, Kanai R, Westman E, Kahn RS, Sisodiya SM, White T, Saremi A, van Bokhoven H, Brunner HG, Völzke H, Wright MJ, van ‘t Ent D, Nöthen MM, Ophoff RA, Buitelaar JK, Fernández G, Sachdev PS, Rietschel M, van Haren NEM, Fisher SE, Beiser AS, Francks C, Saykin AJ, Mather KA, Romanczuk-Seiferth N, Hartman CA, DeStefano AL, Heslenfeld DJ, Weiner MW, Walter H, Hoekstra PJ, Nyquist PA, Franke B, Bennett DA, Grabe HJ, Johnson AD, Chen C, van Duijn CM, Lopez OL, Fornage M, Wardlaw JM, Schmidt R, DeCarli C, De Jager PL, Villringer A, Debette S, Gudnason V, Medland SE, Shulman JM, Thompson PM, Seshadri S, Ikram MA.

Nat Genet. 2019 Nov;51(11):1624-1636. doi: 10.1038/s41588-019-0511-y. Epub 2019 Oct 21.