2018 Publications

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue  Cardamone MD, Orofino J, Labadorf A, Perissi V. J Vis Exp. 2018 Nov 21;(141). doi: 10.3791/58682.

Impaired Glucocorticoid Suppression of TGFβ Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis Lee MJ, Pickering RT, Shibad V, Wu Y, Karastergiou K, Jager M, Layne MD, Fried SK. Diabetes. 2018 Dec 7. pii: db180955. doi: 10.2337/db18-0955. [Epub ahead of print]

Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis Barron AMS, Mantero JC, Ho JD, Nazari B, Horback KL, Bhawan J, Lafyatis R, Lam C, Browning JL. J Immunol. 2018 Dec 3. pii: ji1801209. doi: 10.4049/jimmunol.1801209.

Patients with systemic sclerosis-associated pulmonary arterial hypertension express a genomic signature distinct from patients with interstitial lung disease Moll M, Christmann RB, Zhang Y, Whitfield ML, Wang YM, Rice L, Stratton E, Lafyatis R, Farber HW. J Scleroderma Relat Disord. 2018 Oct;3(3):242-248. doi: 10.1177/2397198318764780.

Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S. Am J Med Genet B Neuropsychiatr Genet. 2018 Nov 23. doi: 10.1002/ajmg.b.32691.

TIA1 regulates the generation and response to toxic tau oligomers Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. Acta Neuropathol. 2018 Nov 21.

The Multiple Hit Hypothesis for Gulf War Illness: Self-Reported Chemical/Biological Weapons Exposure and Mild Traumatic Brain Injury Janulewicz P, Krengel M, Quinn E, Heeren T, Toomey R, Killiany R, Zundel C, Ajama J, O’Callaghan J, Steele L, Klimas N, Sullivan K. Brain Sci. 2018 Nov 13;8(11). pii: E198. doi: 10.3390/brainsci8110198.

Variation in TMEM106B in chronic traumatic encephalopathy  Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Acta Neuropathol Commun. 2018 Nov 4;6(1):115. doi: 10.1186/s40478-018-0619-9.

Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.  Petcherski A, Trudeau KM, Wolf DM, Segawa M, Lee J, Taddeo EP, Deeney JT, Liesa M. J Mol Biol. 2018 Dec 7;430(24):4823-4833.

Quantification of discrete behavioral components of the MDS-UPDRS Brooks C, Eden G, Chang A, Demanuele C, Kelley Erb M, Shaafi Kabiri N, Moss M, Bhangu J, Thomas K. J Clin Neurosci. 2018 Oct 29.

Derivation and characterization of putative craniofacial mesenchymal progenitor cells from human induced pluripotent stem cells Jamal M, Lewandowski SL, Lawton ML, Huang GT, Ikonomou L. Stem Cell Res. 2018 Dec;33:100-109.

Phosphatidic Acid Signals via the Hippo Pathway Stampouloglou E, Varelas X.  Mol Cell. 2018 Oct 18;72(2):205-206.

Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin Apostolidis SA, Stifano G, Tabib T, Rice LM, Morse CM, Kahaleh B, Lafyatis R. Front Immunol. 2018 Oct 1;9:2191.

Impulsive choice does not predict binge-like eating in rats Moore CF, Blasio A, Sabino V, Cottone P. Behav Pharmacol. 2018 Dec;29(8):726-731. doi: 10.1097/FBP.0000000000000446.

Extensive CD34-to-CD90 Fibroblast Transition Defines Regions of Cutaneous Reparative, Hypertrophic, and Keloidal Scarring Ho JD, Chung HJ, Ms Barron A, Ho DA, Sahni D, Browning JL, Bhawan J. Am J Dermatopathol. 2018 Sep 4.

Association of Varus Knee Thrust during Walking with Worsening WOMAC Knee Pain: The Multicenter Osteoarthritis Study Wink AE, Gross KD, Brown CA, Lewis CE, Torner J, Nevitt MC, Tolstykh I, Sharma L, Felson DT.Arthritis Care Res (Hoboken). 2018 Sep 22..

Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. iScience. 2018 Jul 27;5:99-109. doi: 10.1016/j.isci.2018.07.005.

Medial Temporal Lobe Amnesia Is Associated with a Deficit in Recovering Temporal Context Palombo DJ, Di Lascio JM, Howard MW, Verfaellie M.  J Cogn Neurosci. 2018 Sep 21:1-13. doi: 10.1162/jocn_a_01344.

Identification of a novel gene fusion in ALT positive osteosarcoma Mason-Osann E, Dai A, Floro J, Lock YJ, Reiss M, Gali H,Matschulat A, Labadorf A, Flynn RL. Oncotarget. 2018 Aug 28;9(67):32868-32880. doi: 10.18632/oncotarget.26029. eCollection 2018 Aug 28.

Single-platform ‘multi-omic’ profiling: unified mass spectrometry and computational workflows for integrative proteomics-metabolomics analysis Blum BC, Mousavi F, Emili A.  Mol Omics. 2018 Oct 8;14(5):307-319. doi: 10.1039/c8mo00136g. Review.

A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.

A Chimeric Lloviu Virus Minigenome System Reveals that the Bat-Derived Filovirus Replicates More Similarly to Ebolaviruses than Marburgviruses  Manhart WA, Pacheco JR, Hume AJ, Cressey TN, Deflubé LR, Mühlberger E. Cell Rep. 2018 Sep 4;24(10):2573-2580.e4. doi: 10.1016/j.celrep.2018.08.008.

Retinoic acid signaling is essential for airway smooth muscle homeostasis Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. JCI Insight. 2018 Aug 23;3(16). pii: 120398. doi: 10.1172/jci.insight.120398.

O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans Taub DG, Awal MR, Gabel CV. Cell Rep. 2018 Aug 21;24(8):1931-1938.e3. doi: 10.1016/j.celrep.2018.07.078.

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington’s Disease Goodliffe JW, Song H, Rubakovic A, Chang W, Medalla M, Weaver CM, Luebke JI. PLoS One. 2018 Aug 17;13(8):e0200626.

Individual islet respirometry reveals functional diversity within the islet population of mice and human donors Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. Mol Metab. 2018 Oct;16:150-159. doi: 10.1016/j.molmet.2018.07.003.

RNA binding proteins co-localize with small tau inclusions in tauopathy Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B. Acta Neuropathol Commun. 2018 Aug 1;6(1):71.

CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML.  Sci Signal. 2018 Jul 31;11(541).

Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells  McCauley KB, Hawkins F, Kotton DN. Curr Protoc Stem Cell Biol. 2018 May;45(1):e51. doi: 10.1002/cpsc.51. Epub 2018 May 4.

A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics  Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. Amyloid. 2018 Sep;25(3):148-155. doi: 10.1080/13506129.2018.1489228. Epub 2018 Jul 21.

Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation   Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Neurosci Lett. 2018 Sep 25;684:109-114. doi: 10.1016/j.neulet.2018.07.015. Epub 2018 Jul 9.

The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus Hsieh IN, De Luna X, White MR, Hartshorn KL. Front Immunol. 2018 Jun 13;9:1368. doi: 10.3389/fimmu.2018.01368. eCollection 2018. Review.

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6428-E6436. doi: 10.1073/pnas.1802977115. Epub 2018 Jun 25.

Directed evolution of a picomolar-affinity, high-specificity antibody targeting phosphorylated tau Li D, Wang L, Maziuk BF, Yao X, Wolozin B, Cho YK. J Biol Chem. 2018 Aug 3;293(31):12081-12094. doi: 10.1074/jbc.RA118.003557.

Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Nucleic Acids Res. 2018 Jul 27;46(13):6785-6796. doi: 10.1093/nar/gky480.

Skin Gene Expression Is Prognostic for the Trajectory of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis Stifano G, Sornasse T, Rice LM, Na L, Chen-Harris H, Khanna D, Jahreis A, Zhang Y, Siegel J, Lafyatis R. Arthritis Rheumatol. 2018 Jun;70(6):912-919

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN.  Biochemistry. 2018 Jul 3;57(26):3741-3751. doi: 10.1021/acs.biochem.8b00384. Epub 2018 Jun 13.

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel Bolgioni AF, Vittoria MA, Ganem NJ.  J Vis Exp. 2018 May 14;(135). doi: 10.3791/57383.

Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue  Jager M, Lee MJ, Li C, Farmer SR, Fried SK, Layne MD. PLoS One. 2018 May 25;13(5):e0197777. doi: 10.1371/journal.pone.0197777. eCollection 2018.

Late Positive Component Event-related Potential Amplitude Predicts Long-term Classroom-based Learning Turk KW, Elshaar AA, Deason RG, Heyworth NC, Nagle C, Frustace B, Flannery S, Zumwalt A, Budson AE. J Cogn Neurosci. 2018 Sep;30(9):1323-1329

Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells Yang CS, Stampouloglou E, Kingston NM, Zhang L, Monti S, Varelas X. EMBO Rep. 2018 Jun;19(6). pii: e43577.

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Stem Cell Reports. 2018 May 8;10(5):1579-1595.

Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ.  Stem Cells. 2018 Jul;36(7):1004-1019. doi: 10.1002/stem.2822.

Critical role of C-terminal residues of the Alzheimer’s associated β-amyloid protein in mediating antiviral activity and modulating viral and bacterial interactions with neutrophils  White MR, Kandel R, Hsieh IN, De Luna X, Hartshorn KL. PLoS One. 2018 Mar 16;13(3):e0194001. doi: 10.1371/journal.pone.0194001.

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward  Moore CF, Sabino V, Cottone P.Front Pharmacol. 2018 Feb 27;9:129. doi: 10.3389/fphar.2018.00129.

BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironment Andrieu GP, Shafran JS, Deeney JT, Bharadwaj KR, Rangarajan A, Denis GV. J Leukoc Biol. 2018 Aug;104(2):265-274. Review.

Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey Moore TL, Bowley BGE, Shultz PL, Calderazzo SM, Shobin EJ, Uprety AR, Rosene DL, Moss MB. Somatosens Mot Res. 2018 Mar;35(1):1-10.

Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific MannerGuillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Cereb Cortex. 2018 Feb 3.

Emerging Biomarkers in Cutaneous Melanoma  Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM. Mol Diagn Ther. 2018 Apr;22(2):203-218. doi: 10.1007/s40291-018-0318-z. Review.

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model   Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350.

Neuropharmacology of compulsive eating    Moore CF, Panciera JI, Sabino V, Cottone PPhilos Trans R Soc Lond B Biol Sci. 2018 Mar 19;373(1742). pii: 20170024. doi: 10.1098/rstb.2017.0024. Review.

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Nat Neurosci. 2018 Jan;21(1):72-80. Epub 2017 Nov 20.

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Arthritis Rheumatol. 2018 Apr;70(4):566-577.

A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. Blood Cells Mol Dis. 2018 Mar;69:1-9. doi: 10.1016/j.bcmd.2017.11.003. Epub 2017 Nov 29.

White matter signal abnormalities in former National Football League players Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. Alzheimers Dement (Amst). 2017 Nov 6;10:56-65. doi: 10.1016/j.dadm.2017.10.003. eCollection 2018.

Cell culture models of fatty acid overload: Problems and solutions   Alsabeeh N, Chausse B, Kakimoto PA, Kowaltowski AJ, Shirihai O. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):143-151. doi: 10.1016/j.bbalip.2017.11.006. Epub 2017 Nov 15. Review.

A large-scale dataset of single and mixed-source short tandem repeat profiles to inform human identification strategies: PROVEDIt  Alfonse LE, Garrett AD, Lun DS, Duffy KR, Grgicak CM. Forensic Sci Int Genet. 2018 Jan;32:62-70.

The Impact of Glottal Configuration on Speech Breathing. Heller Murray ES, Michener CM, Enflo L, Cler GJ, Stepp CE.J Voice. 2018 Jul;32(4):420-427. doi: 10.1016/j.jvoice.2017.07.001. Epub 2017 Aug 31.

The emerging role and targetability of the TCA cycle in cancer metabolism.  Anderson NM, Mucka P, Kern JG, Feng H.Protein Cell. 2018 Feb;9(2):216-237. doi: 10.1007/s13238-017-0451-1. Epub 2017 Jul 26. Review.

Atypical activation of the G protein Gα_q by the oncogenic mutation Q209P. Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M. J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291.