2014 Student Publications

Rare genetic variant analysis on blood pressure in related samples.Chen H, Choi SH, Hong J, Lu C, Milton JN, Allard C, Lacey SM, Lin H, Dupuis J. BMC Proc. 2014 Jun 17;8(Suppl 1):S35.

Chromophore supply rate-limits mammalian photoreceptor dark adaptation. Wang JS, Nymark S, Frederiksen R, Estevez ME, Shen SQ, Corbo JC, Cornwall MC, Kefalov VJ. J Neurosci. 2014 Aug 20;34(34):11212-21. doi:10.1523/JNEUROSCI.1245-14.2014.

Protein expression of the chemokine receptor CXCR4 and its ligand CXCL12 in primary cutaneous melanoma–biomarkers of potential utility? Hum Mitchell B, Leone D, Feller K, Menon S, Bondzie P, Yang S, Park HY, Mahalingam M. Pathol. 2014 Oct;45(10):2094-100. doi: 10.1016/j.humpath.2014.06.018. Epub 2014 Jul 2.

Amylin and its analogs: a friend or foe for the treatment of Alzheimer’s disease? Qiu WQ, Zhu H. Front Aging Neurosci. 2014 Jul 29;6:186. doi: 10.3389/fnagi.2014.00186. eCollection 2014

Interaction of LRRK2 with kinase and GTPase signaling cascades. Boon JY, Dusonchet J, Trengrove C, Wolozin B. Front Mol Neurosci. 2014 Jul 9;7:64. doi: 10.3389/fnmol.2014.00064. eCollection 2014. Review.

A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH Mol Pharmacol. 2014 Oct;86(4):390-8. doi: 10.1124/mol.114.094128. Epub 2014 Jul 23.

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. Dev Cell. 2014 Jul 28;30(2):137-50.

Substance P mediates reduced pneumonia rates after traumatic brain injury.Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG, Lentsch AB Crit Care Med. 2014 Sep;42(9):2092-100.

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease.Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee da Y, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. Nat Med. 2014 Aug;20(8):886-96. doi: 10.1038/nm.3639. Epub 2014 Jun 29

Specialized pathways from the primate amygdala to posterior orbitofrontal cortex. Timbie C, Barbas H. J Neurosci. 2014 Jun 11;34(24):8106-18. doi: 10.1523/JNEUROSCI.5014-13.2014.

Self-reported concussion history: impact of providing a definition of concussion. Robbins CA, Daneshvar DH, Picano JD, Gavett BE, Baugh CM, Riley DO, Nowinski  CJ, McKee AC, Cantu RC, Stern RA. Open Access J Sports Med. 2014 May 7;5:99-103. doi: 10.2147/OAJSM.S58005. eCollection 2014.

Virus particle release from glycosphingolipid-enriched microdomains is essential  for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus.Akiyama H, Miller C, Patel HV, Hatch SC, Archer J, Ramirez NG, Gummuluru S. J Virol. 2014 Aug;88(16):8813-25. doi: 10.1128/JVI.00992-14. Epub 2014 May 28.

Insights into the architecture of the eIF2Bﺧ١/ﺧ٢/ﺧ٤ regulatory subcomplex. Bogorad AM, Xia B, Sandor DG, Mamonov AB, Cafarella TR, Jehle S, Vajda S, Kozakov D, Marintchev A. Biochemistry. 2014 Jun 3;53(21):3432-45. doi: 10.1021/bi500346u. Epub 2014 May 20.

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Blood. 2014 Jul 31;124(5):791-802. doi: 10.1182/blood-2013-11-536003. Epub 2014 Apr 22.

Amyloidogenic mutations in  human apolipoprotein A-I are not necessarily destabilizing – a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. Das M, Mei X, Jayaraman S, Atkinson D, Gursky O. FEBS J. 2014 Jun;281(11):2525-42. doi: 10.1111/febs.12809. Epub 2014 Apr 28.

Chemerin levels as predictor of acute coronary events: a case-control study nested within the veterans affairs normative aging study.Aronis KN, Sahin-Efe A, Chamberland JP, Spiro A 3rd, Vokonas P, Mantzoros CS. Metabolism. 2014 Jun;63(6):760-6

Trinkaus-Randall V. Hypoxia induced changes in Ca(2+) mobilization and protein phosphorylation implicated in impaired wound healing. Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Am J Physiol Cell Physiol. 2014 May 15;306(10):C972-85.

The transcriptional regulators TAZ and YAP direct transforming growth factor Beta-induced tumorigenic phenotypes in breast  cancer cells. Hiemer SE, Szymaniak AD, Varelas X. J Biol Chem. 2014 May 9;289(19):13461-74. doi: 10.1074/jbc.M113.529115. Epub 2014 Mar 19.

ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor Liu-Yesucevitz L, Lin AY, Ebata A, Boon JY, Reid W, Xu YF, Kobrin K, Murphy  GJ, Petrucelli L, Wolozin B. . J Neurosci. 2014 Mar 19;34(12):4167-74. doi: 10.1523/JNEUROSCI.2350-13.2014.

Regional alterations in purkinje cell density in patients with autism. Skefos J, Cummings C, Enzer K, Holiday J, Weed K, Levy E, Yuce T, Kemper T,  Bauman M. PLoS One. 2014 Feb 24;9(2):e81255. doi: 10.1371/journal.pone.0081255. eCollection 2014.

MicroRNAs located in the Hox gene clusters are implicated in huntington’s disease pathogenesis. Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, Weng Z, Myers RH. PLoS Genet. 2014 Feb 27;10(2):e1004188. doi: 10.1371/journal.pgen.1004188. eCollection 2014 Feb.

Understanding concussion reporting using a model based on the theory of planned behavior. Kroshus E, Baugh CM, Daneshvar DH, Viswanath K. J Adolesc Health. 2014 Mar;54(3):269-274.e2. doi: 10.1016/j.jadohealth.2013.11.011.

Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2  diabetes Hartman ML, Shirihai OS, Holbrook M, Xu G, Kocherla M, Shah A, Fetterman JL, Kluge MA, Frame AA, Hamburg NM, Vita JA.  mellitus. Vasc Med. 2014 Feb;19(1):67-74.

Association between amylin and amyloid-ﺧ٢ peptides in plasma in the context of apolipoprotein E4 allele.Qiu WQ, Wallack M, Dean M, Liebson E, Mwamburi M, Zhu H PLoS One. 2014 Feb 10;9(2):e88063. doi: 10.1371/journal.pone.0088063. eCollection 2014.

MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression.Patel K, Kollory A, Takashima A, Sarkar S, Faller DV, Ghosh SK. Cancer Lett. 2014 May 28;347(1):54-64. doi: 10.1016/j.canlet.2014.01.020. Epub 2014 Jan 31.

Fruits, vegetables, and  hypertensive disease mortality.Sharma S, Kolahdooz F, Vik S, Green DM, Kolonel LN. Epidemiology. 2014 Mar;25(2):317-9.:

Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. FASEB J. 2014 May;28(5):1975-87. doi: 10.1096/fj.13-233445. Epub 2014 Jan 27.

Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632 Gong H, Yang CY. . J Ocul Pharmacol Ther. 2014 Mar-Apr;30(2-3):143-53. doi: 10.1089/jop.2013.0192. Epub 2014 Jan 24. Review.

Interleukin 1 receptor 1 and interleukin 1ﺧ٢ regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552-64. doi: 10.1161/ATVBAHA.113.302700. Epub 2014 Jan  23.

Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study. Levy D, Freedman JE, Benjamin EJ. Heart Rhythm. 2014 Apr;11(4):663-9. doi: 10.1016/j.hrthm.2014.01.018. Epub 2014 Jan 18.

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. EMBO J. 2014 Mar 3;33(5):418-36. doi: 10.1002/embj.201385014. Epub 2014 Jan 15.

DNA hypermethylation of  serotonin transporter gene promoter in drug naﺃﺥve patients with schizophrenia.Abdolmaleky HM, Nohesara S, Ghadirivasfi M, Lambert AW, Ahmadkhaniha H, Ozturk S, Wong CK, Shafa R, Mostafavi A, Thiagalingam S. Schizophr Res. 2014 Feb;152(2-3):373-80.

Epigenetic mechanisms of Rubinstein-Taybi syndrome. Park E, Kim Y, Ryu H, Kowall NW, Lee J, Ryu H. Neuromolecular Med. 2014 Mar;16(1):16-24. doi: 10.1007/s12017-013-8285-3. Epub 2014 Jan 1.

In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.Muthu P, Liang J, Schmidt W, Moore JR, Szczesna-Cordary D. Arch Biochem Biophys. 2014 Jun 15;552-553:29-39. doi: 10.1016/j.abb.2013.12.011. Epub 2013 Dec 26.

Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor ﺧ٢ receptor-dependent and -independent pathways Tumelty KE, Smith BD, Nugent MA, Layne MD. . J Biol Chem. 2014 Jan 31;289(5):2526-36. doi: 10.1074/jbc.M113.502617. Epub 2013 Dec 16.

Relation of hypothyroidism and incident atrial fibrillation (from the Framingham  Heart Study).Kim EJ, Lyass A, Wang N, Massaro JM, Fox CS, Benjamin EJ, Magnani JW. Am Heart J. 2014 Jan;167(1):123-6. doi: 10.1016/j.ahj.2013.10.012.  Epub 2013 Oct 19.

Properties of the Driving Behavior Survey among individuals with motor vehicle accident-related posttraumatic stress disorder.Clapp JD, Baker AS, Litwack SD, Sloan DM, Beck JG. J Anxiety Disord. 2014 Jan;28(1):1-7. doi: 10.1016/j.janxdis.2013.10.008. Epub 2013 Nov 20.

Early murine polymicrobial sepsis predominantly causes renal injury.Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG. Shock. 2014  Feb;41(2):97-103.

A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets.Adamia S, Haibe-Kains B, Pilarski PM, Bar-Natan M, Pevzner S, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Burke J, Galinsky I, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Stone R, Griffin JD Clin Cancer Res. 2014 Mar 1;20(5):1135-45.

Integration of basic science and clinical medicine: the innovative approach of the cadaver biopsy project at the Boston University School of Medicine. Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O’Hara C, Joseph L. Acad Med. 2014 Jan;89(1):50-3.

Direct detection of S-palmitoylation by mass spectrometry. Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Anal Chem. 2013 Dec 17;85(24):11952-9. doi: 10.1021/ac402850s. Epub 2013 Dec 6.

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.Freilich RW, Woodbury ME, Ikezu T. PLoS One. 2013 Nov 11;8(11):e79416. doi: 10.1371/journal.pone.0079416. eCollection 2013. PubMed

ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription.Hwang YJ, Han D, Kim KY, Min SJ, Kowall NW, Yang L, Lee J, Kim Y, Ryu H. Nucleic Acids Res. 2014 Feb;42(3):1628-43. doi: 10.1093/nar/gkt1041. Epub 2013 Nov 14.

Pseudocarcinomatous hyperplasia involving the ear from gout: a diagnostic pitfall.Morrissey KA, Garcia-Albea V, Goldberg LJ. J Cutan Pathol. 2014 Jan;41(1):42-4. doi: 10.1111/cup.12249.

Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to  social impairments measured using the Social Impairment Rating Scale. J Bickart KC, Brickhouse M, Negreira A, Sapolsky D, Barrett LF, Dickerson BC.  Neurol Neurosurg Psychiatry. 2014 Apr;85(4):438-48.

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. Eisenstein A, Ravid K. J Cell Physiol. 2014 Apr;229(4):414-21.

Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. Woodbury ME, Ikezu T. J Neuroimmune Pharmacol. 2014 Mar;9(2):92-101. doi: 10.1007/s11481-013-9501-5. Epub 2013 Sep 21. Review.

The effect of STAT3 inhibition on status epilepticus  and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. Neurobiol Dis. 2014 Feb;62:73-85.

Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. Qiu WW, Lai A, Mon T, Mwamburi M, Taylor W, Rosenzweig J, Kowall N, Stern R, Zhu H, Steffens DC. Am J Geriatr Psychiatry. 2014 Feb;22(2):177-85. doi: 10.1016/j.jagp.2012.08.017. Epub 2013 Apr 3.

ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. Oncogene. 2014 Jan 9;33(2):212-24. doi: 10.1038/onc.2012.564. Epub 2012 Dec 17.