The Cohen lab studies the molecular basis of renal cancer, renal cystic disease and renal development, and offers special expertise in gene expression mechanisms, signal transduction, protein-protein interactions, transcription factors, and renal epithelial cell biology. The laboratory has identified the first member of a new protein family, the Jade family of proteins. Jade-1 is a novel growth suppressive transcription factor that is stabilized by pVHL, a key component of the cellular oxygen sensing system. Jade 1 has important roles in autosomal dominant polycystic kidney disease (ADPKD), renal cancer, renal cyst formation, and renal development.
Five selected publications:
1. Zhou MI et al. Jade-1, a candidate renal tumor suppressor that promotes apoptosis. Proceeds of the National Academy of Sciences of the United States of America, 2005. PMID: 16046545
2. Cohen HT and McGovern FJ. Renal-cell carcinoma. New England Journal of Medicine, 2005. PMID: 16339066
3. Chitalia VC et al. Jade-1 inhibits Wnt signaling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nature Cell Biology, 2008. PMID: 18806787
4. Foy RL et al. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Human Molecular Genetics, 2012. PMID: 23001567
5. Zheng L et al. Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma. Cancer Research, 2013. PMID: 23824745