Double teaming Mr. Bean
72 y/o F with recent diagnosis of pulmonary fibrosis secondary to ANCA-MPO + vasculititis presents with acute renal failure with dysmorphic RBCs on U/A. Pt was initially diagnosed with ANCA-MPO + glomerulonephritis and started on high dose steroids and immunosuppressants. Following biopsy, pt noted to have linear IgG deposits along basement membrane which alongside + anti-GBM assay also supported a diagnosis of Goodpasture’s.
Twenty-Eight years with ANCA: how to test for ANCA – evidence -based immunology ?
Pulmonary Fibrosis in myeloperoxidase ANCA-associated Vasculitidies
Clinical features and outcome of patients with both ANCA and anti-GBM antibodies