Double teaming Mr. Bean

72 y/o F with recent diagnosis of pulmonary fibrosis secondary to ANCA-MPO + vasculititis  presents with acute renal failure with dysmorphic RBCs on U/A.  Pt was initially diagnosed with ANCA-MPO + glomerulonephritis and started on high dose steroids and immunosuppressants. Following biopsy, pt noted to have linear IgG deposits along basement membrane which alongside + anti-GBM assay also supported a diagnosis of Goodpasture’s.

 

ANCA Small Vessel Vasculitis

Twenty-Eight years with ANCA: how to test for ANCA – evidence -based immunology ?

Pulmonary Fibrosis in myeloperoxidase ANCA-associated Vasculitidies

Clinical features and outcome of patients with both ANCA and anti-GBM antibodies