Kostas Alysandratos MD, PHD

Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

670 Albany St | (617) 414-2969
Kostas Alysandratos

Pulmonary, Allergy, Sleep & Critical Care Medicine


Center for Regenerative Medicine

Pulmonary Center

Evans Center for Interdisciplinary Biomedical Research


Dr. Konstantinos D. Alysandratos, MD, PhD is an Assistant Professor in the Department of Medicine at Chobanian and Avedisian School of Medicine and is part of the team at the Center for Regenerative Medicine at Boston University as part of Dr. Darrell N. Kotton’s lab. He received his Doctorate of Medicine from the University of Athens and embarked on his research journey after winning a competitive 3-year scholarship from the Hellenic State Scholarships Foundation. As part of his doctoral work under the mentorship of Dr. Theoharides at Tufts University, he studied the interplay between neuropeptides and cytokines in the pathogenesis of atopic dermatitis and their role on mast cell activation. He has also contributed to translational discoveries relating to mast cell activation in neurodevelopmental disorders such as autism spectrum disorders that may inform novel therapeutic approaches. Dr. Alysandratos completed his internal medicine training at UT Southwestern Medical Center, during which time he developed his passion for intensive and pulmonary care.


Medicine, MD, University of Athens

Immunology/Pharmacology, PhD, University of Athens


Published on 4/12/2018

McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595. PMID: 29657097.

Published on 9/25/2017

Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893. PMID: 28947536.

Published on 1/1/2017

Alysandratos KD, Serra M, Mulugeta S, Beers MF, Kotton DN. Am J Respi Crit Care
Med. Deriving alveolar type 2 cells from
pluripotent stem cells to model surfactant protein C (SP-C) mutations in vitro. 2017; 195:A4317.

Published on 11/2/2015

Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. PMID: 26525562.

Published on 9/1/2013

Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 2013 Sep; 169(3):695-9. PMID: 24033157.

Published on 1/1/2011

Asadi S, Zhang B, Alysandratos KD, Angelidou A, Vasiadi M, Theoharides TC. J Allergy Clin Immunol. Substance P (SP)
induces expression of functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in human
mast cells. 2011; 127(2 suppl):AB162.

Published on 1/1/2011

Theoharides TC, Angelidou A, Alysandratos KD, Asadi S, Francis K, Lykouras L, Kalogeromitros D. Autism- A Neurodevelopmental Journey from Genes
to Behaviour (Eapen V, Ed.). Perinatal immune activation and risk of autism. Intech Open Access Publisher. Rijeka, Croatia. 2011; 267-88.

Published on 12/28/2010

Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2012 Jan; 1822(1):34-41. PMID: 21193035.

Published on 1/1/2010

Zhang BD, Angelidou A, Alysandratos KD, Tagen M, Kempuraj D, Asadi S, Theoharides TC. FASEB J. Human
mast cell degranulation is distinguished from selective secretion of TNF through intracellular calcium,
energy and mitochondrial morphology dynamics. 2010; 24:996.3.

Published on 1/1/2010

Zhang BD, Alysandratos KD, Angelidou A, Vasiadi M, Kempuraj D, Tagen M, Asadi S, Theoharides
TC. J Immunol. TNF secretion from human mast cells is regulated by mitochondrial dynamics and mitochondrial
uncoupling protein 2 (UCP 2). 2010; 184:135.11.

View full list of 11 publications.