Kostas Alysandratos MD, PHD
Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
670 Albany St | (617) 414-2969
Pulmonary, Allergy, Sleep & Critical Care Medicine
Center for Regenerative Medicine
Evans Center for Interdisciplinary Biomedical Research
Dr. Konstantinos D. Alysandratos, MD, PhD is an Assistant Professor in the Department of Medicine at Boston University School of Medicine and is part of the team at the Center for Regenerative Medicine at Boston University as part of Dr. Darrell N. Kotton’s lab. He received his Doctorate of Medicine from the University of Athens and embarked on his research journey after winning a competitive 3-year scholarship from the Hellenic State Scholarships Foundation. As part of his doctoral work under the mentorship of Dr. Theoharides at Tufts University, he studied the interplay between neuropeptides and cytokines in the pathogenesis of atopic dermatitis and their role on mast cell activation. He has also contributed to translational discoveries relating to mast cell activation in neurodevelopmental disorders such as autism spectrum disorders that may inform novel therapeutic approaches. Dr. Alysandratos completed his internal medicine training at UT Southwestern Medical Center, during which time he developed his passion for intensive and pulmonary care.
Medicine, MD, University of Athens, 2013
Immunology, PhD, University of Athens, 2013
McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595. PMID: 29657097.Published on 9/25/2017
Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893. PMID: 28947536.Published on 1/1/2017
Alysandratos KD, Serra M, Mulugeta S, Beers MF, Kotton DN. Am J Respi Crit Care
Med. Deriving alveolar type 2 cells from
pluripotent stem cells to model surfactant protein C (SP-C) mutations in vitro. 2017; 195:A4317.
Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. PMID: 26525562.Published on 9/1/2013
Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 2013 Sep; 169(3):695-9. PMID: 24033157.Published on 1/1/2011
Asadi S, Zhang B, Alysandratos KD, Angelidou A, Vasiadi M, Theoharides TC. J Allergy Clin Immunol. Substance P (SP)
induces expression of functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in human
mast cells. 2011; 127(2 suppl):AB162.
Theoharides TC, Angelidou A, Alysandratos KD, Asadi S, Francis K, Lykouras L, Kalogeromitros D. Autism- A Neurodevelopmental Journey from Genes
to Behaviour (Eapen V, Ed.). Perinatal immune activation and risk of autism. Intech Open Access Publisher. Rijeka, Croatia. 2011; 267-88.
Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2012 Jan; 1822(1):34-41. PMID: 21193035.Published on 1/1/2010
Zhang BD, Angelidou A, Alysandratos KD, Tagen M, Kempuraj D, Asadi S, Theoharides TC. FASEB J. Human
mast cell degranulation is distinguished from selective secretion of TNF through intracellular calcium,
energy and mitochondrial morphology dynamics. 2010; 24:996.3.
Zhang BD, Alysandratos KD, Angelidou A, Vasiadi M, Kempuraj D, Tagen M, Asadi S, Theoharides
TC. J Immunol. TNF secretion from human mast cells is regulated by mitochondrial dynamics and mitochondrial
uncoupling protein 2 (UCP 2). 2010; 184:135.11.