Abbreviation Monday – HHS and KPD

We discussed a case of a 58 yo M who presents with altered mental status who was found to have HHS, with a glucose of 1018. His presentation is consistent with a subset of Type-II DM, known as Ketosis-Prone Diabetes (KPD). This subset often occurs later in life and a presentation of HHS/DKA can be the first manifestation of the disease.

Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome – Diabetes Spectrum January 2002vol. 15 no. 1 28-36
This article contains a great treatment algorithm for HHS/DKA and also some good tidbits on management of electrolytes. The journal in which it’s published is sponsored by the ADA.

Syndromes of Ketosis-Prone Diabetes – Endocrine Reviews May 1, 2008 vol. 29 no. 3 292-302
A fantastic review of  KPD and some of the underlying pathophysiology and classification schemes.