Andrew J. Henderson, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Research in my laboratory focuses on cellular mechanisms that regulate HIV replication and transcription. Current projects include exploring how signaling influences HIV infection and latency, devising strategies for long-term repression of HIV provirus and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. In addition, we are interested in mechanisms that contribute to HIV associated inflammation. I have served on NIH study sections and special emphasis panels and was a member and chair for the NIH AIDS Molecular and Cellular Biology Study Section. In addition to my research, I have always been proactive in undergraduate and graduate training developing and providing leadership for PhD pipeline programs, and training international researchers.

Publications

  • Published 9/8/2025

    Jalloh S, Hughes IK, Akiyama H, Gojanovich AD, Quiñones-Molina AA, Yang M, Henderson AJ, Mostoslavsky G, Gummuluru S. Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells. PLoS Biol. 2025 Sep; 23(9):e3003320. PMID: 40920844.

    Read at: PubMed

  • Published 8/25/2025

    Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S. 5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5. bioRxiv. 2025 Aug 25. PMID: 40909469.

    Read at: PubMed

  • Published 6/10/2025

    Ramaswamy S, Akiyama H, Berrigan J, Quiñones-Molina AA, Olson AJ, Chen Y, Liang Y, Henderson AJ, Asundi A, Sagar M, Gummuluru S. The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses. J Clin Invest. 2025 Aug 15; 135(16). PMID: 40493408.

    Read at: PubMed

  • Published 5/9/2024

    Kilroy JM, Leal AA, Henderson AJ. Chronic HIV Transcription, Translation, and Persistent Inflammation. Viruses. 2024 May 09; 16(5). PMID: 38793632.

    Read at: PubMed

  • Published 2/1/2023

    Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2). PMID: 36851631.

    Read at: PubMed

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Other Positions

  • Assistant Dean, Oral Health Sciences
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Professor, Virology, Immunology & Microbiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Co-Director, Clinical and Translational Science Institute
    Boston University

Websites

Education

  • University of California, Riverside, PhD
  • University of California, Riverside, MS
  • University of California, Riverside, BS

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