Nicholas A. Crossland, DVM, DACVP

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine and an Investigator at the NEIDL where he directs the NEIDL Comparative Pathology Laboratory (NCPL).

His lab aims to elucidate pathogen-host interactions of highly pathogenic microbes. His lab complements classic pathology approaches with cutting edge technologies such as high throughput tissue staining, spatial transcriptomics and quantitative image analysis. This approach enables the discovery of biological pathways driving and preventing disease. At the translational level, we use our expertise to evaluate the efficacy of medical counter measures with the ultimate goal of alleviating and preventing human suffering.

His lab mentors both MS and PhD students that have their sites on pursuing a career in translational research. He is actively exploring collaborative opportunities with other BUMC faculty members to push the outputs achieved from tissue based assays to drive discovery and enhance our understanding of host-pathogen interactions.

Publications

  • Published 1/27/2026

    Sajjad U, Crossland NA, Gurcan MN, Beamer G, Niazi MKK. Deep Learning-Based Spatial Immunoprofiling of Multiplex Immunofluorescence Images Distinguishes Tuberculosis Disease States in Diversity Outbred Mice. bioRxiv. 2026 Jan 27. PMID: 41659494.

    Read at: PubMed

  • Published 11/24/2025

    Flores EY, Hume AJ, Olejnik J, Mithal A, D'Amico A, Yang M, Bawa P, Wang F, O'Connell AK, Tseng A, Crossland NA, Mostoslavsky G, Mühlberger E. Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids. PLoS Pathog. 2025 Nov; 21(11):e1013698. PMID: 41284734.

    Read at: PubMed

  • Published 10/14/2025

    Storm N, Lo M, Crossland N, Seyler-Schmidt M, Staples H, Silva-Ayala D, Laprise AM, St Denis L, Grosz K, O'Connell A, Gertje H, Ripin T, Decker C, Mazur M, Thurman C, Espinoza M, Morrow G, Parks CL, Cooper CL, Griffiths A. An Intranasal Challenge Model in African Green Monkeys (Chlorocebus aethiops) for Mild-to-Moderate COVID-19 Disease Caused by Subvariant XBB.1.5. Viruses. 2025 Oct 14; 17(10). PMID: 41157643.

    Read at: PubMed

  • Published 10/6/2025

    Yabaji SM, Lata S, Tseng AE, Araveti PB, Lo M, Gavrish I, O'Connell AK, Gertje HP, Belkina AC, Thurman CE, Kiyokawa H, Kotton D, Tan S, Endsley JJ, Bishai WR, Crossland N, Kobzik L, Kramnik I. Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization. PLoS Pathog. 2025 Oct; 21(10):e1013563. PMID: 41052208.

    Read at: PubMed

  • Published 10/2/2025

    Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. Elife. 2025 Oct 02; 14. PMID: 41037321.

    Read at: PubMed

View All 75 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Kansas State University, DVM
  • Kansas State University, BS

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