Jean-Jacques Soghomonian, PhD

Associate Professor, Anatomy & Neurobiology

Jean-Jacques Soghomonian
(617) 638-4511
72 E. Concord St Instructional (L)

Biography

Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson’s disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences

Education

  • Université de Montréal, PhD

Classes Taught

  • AN-718
  • GMS BN 777, 778 & 77
  • GMS-AN722
  • MS141-146

Publications

  • Published on 7/21/2017

    Subramanian K, Brandenburg C, Orsati F, Soghomonian JJ, Hussman JP, Blatt GJ. Basal ganglia and autism - a translational perspective. Autism Res. 2017 Nov; 10(11):1751-1775. PMID: 28730641.

    Read at: PubMed
  • Published on 7/14/2017

    Soghomonian JJ, Zhang K, Reprakash S, Blatt GJ. Decreased parvalbumin mRNA levels in cerebellar Purkinje cells in autism. Autism Res. 2017 Nov; 10(11):1787-1796. PMID: 28707805.

    Read at: PubMed
  • Published on 7/15/2015

    Zhang K, Chammas C, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10; 303:586-94. PMID: 26188284.

    Read at: PubMed
  • Published on 6/18/2014

    Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47. PMID: 24952328.

    Read at: PubMed
  • Published on 7/23/2013

    Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease. Brain Res. 2013 Sep 19; 1531:37-47. PMID: 23891794.

    Read at: PubMed
  • Published on 9/9/2010

    Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17. PMID: 20832408.

    Read at: PubMed
  • Published on 3/16/2010

    Soghomonian JJ, Sethares C, Peters A. Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex. Neuroscience. 2010 Jun 16; 168(1):74-81. PMID: 20302918.

    Read at: PubMed
  • Published on 8/4/2009

    Yamamoto N, Soghomonian JJ. Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. Neuroscience. 2009 Nov 10; 163(4):1171-80. PMID: 19660528.

    Read at: PubMed
  • Published on 2/1/2009

    Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2009 Feb; 2(1):50-9. PMID: 19358307.

    Read at: PubMed
  • Published on 4/16/2008

    Yamamoto N, Soghomonian JJ. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Neuroscience. 2008 Jun 26; 154(3):1088-99. PMID: 18495353.

    Read at: PubMed

View 48 more publications: View full profile at BUMC

View all profiles