Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.
Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Brandeis University, PhD
- Grinnell College, AB
- Published on 5/14/2020
Yang JE, Rossignol ED, Chang D, Zaia J, Forrester I, Raja K, Winbigler H, Nicastro D, Jackson WT, Bullitt E. Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus. Sci Rep. 2020 May 14; 10(1):7939. PMID: 32409751.
- Published on 7/9/2019
Zheng W, Andersson M, Mortezaei N, Bullitt E, Egelman E. Cryo-EM structure of the CFA/I pilus rod. IUCrJ. 2019 Sep 01; 6(Pt 5):815-821. PMID: 31576215.
- Published on 6/19/2019
Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M. Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire. Commun Biol. 2019 Jun 19; 2(1):219. PMID: 31925024.
- Published on 6/19/2019
Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M. Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire. Commun Biol. 2019; 2:219. PMID: 31240257.
- Published on 5/2/2019
Jie E. Yang, Evan D. Rossignol, Deborah Chang, Joseph Zaia, Isaac Forrester, Holly Saulsbery, Daniela Nicastro, William T. Jackson, Esther Bullitt. Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus. bioRxiv. 2019.
- Published on 4/11/2018
Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis. 2018 04 11; 217(9):1435-1441. PMID: 29528423.
- Published on 3/6/2018
Wiklund K, Zhang H, Stangner T, Singh B, Bullitt E, Andersson M. A drag force interpolation model for capsule-shaped cells in fluid flows near a surface. Microbiology. 2018 04; 164(4):483-494. PMID: 29509130.
- Published on 1/1/2018
Epler Barbercheck CR, Bullitt E, Andersson M. Bacterial Adhesion Pili. Subcell Biochem. 2018; 87:1-18. PMID: 29464555.
- Published on 4/18/2017
Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika virus induced cellular remodelling. Cell Microbiol. 2017 Aug; 19(8). PMID: 28318141.
- Published on 12/13/2016
Singh B, Mortezaei N, Savarino SJ, Uhlin BE, Bullitt E, Andersson M. Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled. J Bacteriol. 2017 Jan 01; 199(1). PMID: 27795330.
View 40 more publications: View full profile at BUMC