Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.
Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Brandeis University, PhD
- Grinnell College, AB
- Published on 4/18/2017
Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika virus induced cellular remodelling. Cell Microbiol. 2017 Aug; 19(8). PMID: 28318141.
- Published on 12/13/2016
Singh B, Mortezaei N, Savarino SJ, Uhlin BE, Bullitt E, Andersson M. Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled. J Bacteriol. 2017 Jan 01; 199(1). PMID: 27795330.
- Published on 10/12/2015
Rossignol ED, Yang JE, Bullitt E. The Role of Electron Microscopy in Studying the Continuum of Changes in Membranous Structures during Poliovirus Infection. Viruses. 2015 Oct; 7(10):5305-18. PMID: 26473912.
- Published on 9/28/2015
Singh B, Mortezaei N, Uhlin BE, Savarino SJ, Bullitt E, Andersson M. Antibody-mediated disruption of the mechanics of CS20 fimbriae of enterotoxigenic Escherichia coli. Sci Rep. 2015; 5:13678. PMID: 26411657.
- Published on 7/7/2015
Mortezaei N, Singh B, Zakrisson J, Bullitt E, Andersson M. Biomechanical and structural features of CS2 fimbriae of enterotoxigenic Escherichia coli. Biophys J. 2015 Jul 7; 109(1):49-56. PMID: 26153701.
- Published on 6/11/2015
Brown JW, Bullitt E, Sriswasdi S, Harper S, Speicher DW, McKnight CJ. The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. PLoS Comput Biol. 2015 Jun; 11(6):e1004302. PMID: 26067675.
- Published on 11/27/2014
Mortezaei N, Epler CR, Shao PP, Shirdel M, Singh B, McVeigh A, Uhlin BE, Savarino SJ, Andersson M, Bullitt E. Structure and function of enterotoxigenic Escherichia coli fimbriae from differing assembly pathways. Mol Microbiol. 2015 Jan; 95(1):116-26. PMID: 25355550.
- Published on 12/2/2013
Mortezaei N, Singh B, Bullitt E, Uhlin BE, Andersson M. P-fimbriae in the presence of anti-PapA antibodies: new insight of antibodies action against pathogens. Sci Rep. 2013; 3:3393. PMID: 24292100.
- Published on 8/1/2013
Wang J, Ptacek JB, Kirkegaard K, Bullitt E. Double-membraned liposomes sculpted by poliovirus 3AB protein. J Biol Chem. 2013 Sep 20; 288(38):27287-98. PMID: 23908350.
- Published on 4/11/2013
Wang J, Lyle JM, Bullitt E. Surface for catalysis by poliovirus RNA-dependent RNA polymerase. J Mol Biol. 2013 Jul 24; 425(14):2529-40. PMID: 23583774.
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