Esther S. Bullitt, PhD

Associate Professor, Physiology & Biophysics

Esther Bullitt
617.358.8464
700 Albany St Ctr for Adv Biomed Res

Biography

Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.

Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Brandeis University, PhD
  • Grinnell College, AB

Classes Taught

  • GMSBY762
  • GMSBY871
  • GMSPH841

Publications

  • Published on 5/14/2020

    Yang JE, Rossignol ED, Chang D, Zaia J, Forrester I, Raja K, Winbigler H, Nicastro D, Jackson WT, Bullitt E. Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus. Sci Rep. 2020 May 14; 10(1):7939. PMID: 32409751.

    Read at: PubMed
  • Published on 7/9/2019

    Zheng W, Andersson M, Mortezaei N, Bullitt E, Egelman E. Cryo-EM structure of the CFA/I pilus rod. IUCrJ. 2019 Sep 01; 6(Pt 5):815-821. PMID: 31576215.

    Read at: PubMed
  • Published on 6/19/2019

    Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M. Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire. Commun Biol. 2019 Jun 19; 2(1):219. PMID: 31925024.

    Read at: PubMed
  • Published on 6/19/2019

    Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M. Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire. Commun Biol. 2019; 2:219. PMID: 31240257.

    Read at: PubMed
  • Published on 5/2/2019

    Jie E. Yang, Evan D. Rossignol, Deborah Chang, Joseph Zaia, Isaac Forrester, Holly Saulsbery, Daniela Nicastro, William T. Jackson, Esther Bullitt. Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus. bioRxiv. 2019.

    Read at: Custom
  • Published on 4/11/2018

    Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E. A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli. J Infect Dis. 2018 04 11; 217(9):1435-1441. PMID: 29528423.

    Read at: PubMed
  • Published on 3/6/2018

    Wiklund K, Zhang H, Stangner T, Singh B, Bullitt E, Andersson M. A drag force interpolation model for capsule-shaped cells in fluid flows near a surface. Microbiology. 2018 04; 164(4):483-494. PMID: 29509130.

    Read at: PubMed
  • Published on 1/1/2018

    Epler Barbercheck CR, Bullitt E, Andersson M. Bacterial Adhesion Pili. Subcell Biochem. 2018; 87:1-18. PMID: 29464555.

    Read at: PubMed
  • Published on 4/18/2017

    Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika virus induced cellular remodelling. Cell Microbiol. 2017 Aug; 19(8). PMID: 28318141.

    Read at: PubMed
  • Published on 12/13/2016

    Singh B, Mortezaei N, Savarino SJ, Uhlin BE, Bullitt E, Andersson M. Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled. J Bacteriol. 2017 Jan 01; 199(1). PMID: 27795330.

    Read at: PubMed

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