Boston University Blackboard Learn

March 23rd, 2014 in See Also

Congratulations John Mahoney!

March 23rd, 2014 in Student Spotlight

John “Jed” Mahoney

PhD Candidate

Successfully defend his dissertation:

“The Hippo Pathways Effector Yap Controls Patterning and Differentiation of the Airway Epithelium”

Friday, March 21st, 2014

Top Doc in Boston Antonio de las Morenas!

March 23rd, 2014 in Faculty Highlights

Antonio de las Morenas, M.D., Professor of Pathology and Laboratory Medicine has been recognized by Boston magazine as a Top Doc in Boston. According to BU Today, “To be included in Boston magazine’s Top Doc list, physicians undergo a rigorous screening process by national medical research firm Castle Connolly. The firm gathers nominations online from other licensed physicians, conducts phone interviews with medical professionals to corroborate nominations, and checks the professional qualifications of all nominees . . .”

The list of pathologists in Boston in the top docs may be found here:

October 2013

October 28th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –


  • Faculty Appointments and/or Promotions:
    • Dr. Yuriy Alekseyev was promoted to Research Associate Professor
    • Dr. Shinichi Takayama has been appointed as Research Associate ProfessorImmuno Nov 2013
  • Immunology has selected an image from an article authored by Dr. Zhaohua Lu and colleagues, published in this month’s Immunology for the journal cover (see photo and link to article)
  • The Martin Steffen Lab presented a talk on their work on biomarkers for Prostate Cancer at the 2013 meeting for the New England Section of the American Urological Association in Hartford, Connecticut on September 26 – 28 Towards Reducing the Number of Prostate Biopsies – Biomarkers to Identify Patients with Benign Causes of Elevated PSA LevelsAgnes Bergerat, PhD1, Yi-Chien Chang, MS2, Mark Katz, MD1, David Wang, MD1, Simon Kasif, PhD2, Richard Babayan, MD1Martin Steffen, MD, PhD1
  • Dr. Daniel Remick will be giving a lecture on October 28th at the Brigham & Women’s Hospital entitled, “Mechanisms of Alcohol Triggered Asthma”
  • Dr. Carmen Sarita-Reyes is now Board Certified in Pediatric Pathology

Publications: PUBLISHED:

  • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D.,Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., Jason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary Hunter, M. A. “MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia” New England Journal of Medicine; 367;9 nejm.826 org august 30, 2012
  • Lian Xu,1,2  Zachary R. Hunter,1,2 Guang Yang,1,2 Yangsheng Zhou,1,2 Yang Cao,1,2 Xia Liu,1,2 Enrica Morra,3 Alessandra Trojani,3 Antonino Greco,3 Luca Arcaini,4 Marzia Varettoni,4 Jennifer R. Brown,5 Yu-Tzu Tai,2,6 Kenneth C. Anderson,2,6 Nikhil C. Munshi,2,6 Christopher J. Patterson,1 Robert J. Manning,1 Christina K. Tripsas,1 Neal I. Lindeman,2,7 and Steven P. Treon1,2 “MYD88 L265P in Waldenstr¨om macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction” BLOOD, 14 MARCH 2013 x VOLUME 121, NUMBER 11
  • Steven P. Treon1,2 and Zachary R. Hunter1,2 “A new era for Waldenstrom macroglobulinemia: MYD88 L265P,” BLOOD, 30 MAY 2013 x VOLUME 121, NUMBER 22
  • Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. “The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.” Immunology. 2013 Nov;140(3):374-389. PMID: 23844703

September 2013

September 26th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –



  • CAP (College of American Pathologist) 2013, Orlando Florida, October 13-16, 2013; Accepted:
    • “Validation Of Pre-transfusion Compatibility Testing In PEG In A Semi-automated Transfusion Service” (Poster No. 98 – p 1371) – Josenia Tan and Karen Quillen – Abstract accepted to CAP 2013, poster presentation
    • “Benign Epithelial Inclusions In Axillary Lymphnodes” (Poster No. 69 – p 1452) - Anita Deshpande, MD; Josenia Tan, MD; Melinda Lerwill, MD; Grace Zhao, MD; selected abstract for poster presentation at CAP ’13.
    • “Utility Of Fetal Tissue Examination in Intrauterine Fetal Demise Autopsies;” (Poster No. 95 – p 1508)
    • Cathryn Byrne-Dugan, MD, et al – Abstract accepted to CAP 2013, poster presentation
    • From Dr. Carmen Sarita-Reyes: on page 166:; presented by Yue Sun, MD and Antonio de las Morenas, MD; “Anaplastic Thyroid Carcinoma and Potential Therapeutic Target” (Poster No. 152 – p 1525)
  • Dr. Daniel Remick was the Keynote Speaker, 15th Congress of the European Shock Society, Vienna Austria, September 2013; “Sepsis, When you die we want to know why”
  • Dr. Remick also participated in “Meet the Expert, Ludwig Boltzmann Institute of Traumatology,” Vienna Austria in September 2013
  • Daoreuang Pongvongkeo, Angel Lui, Genevieve Matnog, and John Lee from the Hematology Lab have validated a new automated urinalysis platform, the iRICELL Plus, that went live 9/9/13. This new automated platform will improve efficiency in performing and releasing urinalysis results.
  • Dr. Barbara Nikolajczyk presented her teams’ work “Lymphocytes regulate inflammation in human type 2 diabetes” at the Aegean Conference on Immunometabolism in Rhodes, Greece, September 17, 2013
  • Dr. Barb Nikolajczyk also presented her teams’ work “Roles of B cells in type 2 diabetes and T2D-associated periodontal disease” at the Forsyth Institute in Cambridge, MA September 26, 2013
  • Dr. David Sherr was featured in an article in International Innovations in which I discuss the role of the environment in breast cancer progression. See the URL below.
  • Dr. Daniel Remick was the Keynote Speaker, at the 11th Annual Advances in Inflammation Research, Brown University, September 26th & 27th; “The roles of adenosine and antibodies in sepsis”
  • Daniel Remick, MD is the Chair and invited speaker, 46th Annual Meeting of the Society for Leukocyte Biology, Providence Rhode Island, “Leukocytes and mediators that influence survival”
  • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
  • Resident Manisha Mehta, MD has had her abstract, ‘Vitreous cytology: A diagnostic glimpse into the eye’ Manisha Mehta, MD; Reena Rashid, MD; Stephen Foster, MD; Nora Laver, MD, accepted as a talk at the” target=”_blank” title=””>2013 AAOOP (American Association of Ocular Oncologists and Pathologists) Annual Meeting>, “Memorial Celebration of the Life and Work of Dr. Lorenz E. Zimmerman with Anastasia Zimmerman” on November 15th in New Orleans
  • The Nikolajczyk Lab has received a 1 year Diabetes Complications Consortium Grant from the NIH
  • Welcome to our NEW dedicated Residency Program Coordinator, Mark Uva!

August 2013

September 5th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –



  • Chad Mayer, MD/PhD Student in the Kurosawa Lab is the recipient of the 2014, MD/PhD Student Conference Diversity Award from the Medical Sciences Training Program; and he received a check for $500.00
  • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
  • Dr. Shinichiro Kurosawa received an NIH/NIAID R01 award to continue his laboratory’s basic and translational research with enterohemorrhagic E.coli and the bacterial toxins
  • Nancy S. Miller, MD will present Grand Rounds at the University of Massachusetts, Lowell, in October
  • Dr. David Sherr’s Lab, along with Stefano Monti’s, was awarded a supplement to their Superfund Research Program to apply computational biology and high throughput genomics to define transcriptional signatures of carcinogenicity
  • Dr. Barbara Nikolajczyk:
    • has been invited to give a Seminar at the 2nd Aegean Conference on Immunometabolism meeting, Rhodes, Greece, September 2013. “Lymphocytes regulate inflammation in human type 2 diabetes”
    • Dr. Nikolajczyk will also serve on the HAI (Hypersensitivity, Allergy and Immune-mediated diseases) study section in October 2013
    • Dr. Barbara Nikolajczyk has also been invited to co-chair and speak in a Major Symposium at the American Association of Immunologists meeting in Pittsburgh, PA in May 2014

Publications: PUBLISHED:

  • Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ.”NELF coordinates RNA polymerase II pausing, premature termination and chromatin remodeling to regulate HIV transcription.” J Biol Chem. 2013 Jul 24

July 2013

August 15th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items


  • Nancy S. Miller, MD will be President-elect of the Northeast Branch of the American Society for Microbiology, for the one-year term commencing July 1, 2013
  • Daniel Remick, MD was elected to chair the Research Committee of the Association of Pathology Chairs. With this election he will continue as a member of council
  • Parul Agnihotri, PhD Candidate, has been invited to attend the International Graduate Student Immunology Conference in Marseilles, France from August 29-31st. The conference will be take place at the Centre d’Immunologie de Marseille-Luminy (CIML). The title of Parul’s talk will be: “Foxo1: A Potential Target of Ikaros in Regulating Peripheral CD4 T Cell Development”
  • Daniel Remick, MD was an invited speaker at the 2013 Annual Meeting of the Association of Pathology Chairs in the session on Benchmarking Academic Pathologists. His presentation was on using the CARTS methodology to determine budgeting. The APC Meeting was held in Boston this year from July 9 – 12, 2013
  • Cytology Fellow, Josenia Tan, MD, successfully passed her AP and CP Boards; congratulations Joy!


Publications: ACCEPTED:

  • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology (In Press)
  • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. (In Pres)
  • Paper accepted in PLoS Biology describing our efforts to build a community of computational and experimental biologists collaborating to experimentally validate gene function: “The COMBREX Project: Design, Methodology, and Initial Results;” Brian P. Anton, Yi-Chien Chang, Peter Brown, Han-Pil Choi, Lina L. Faller, Jyotsna Guleria, Zhenjun Hu, Niels Klitgord, Ami Levy-Moonshine, Almaz Maksad, Varun Mazumdar, Mark McGettrick, Lais Osmani, Revonda Pokrzywa, John Rachlin, Rajeswari Swaminathan, Benjamin Allen, Genevieve Housman, Caitlin Monahan, Krista Rochussen, Kevin Tao, Ashok S. Bhagwat, Steven E. Brenner, Linda Columbus, Valérie de Crécy-Lagard, Donald Ferguson, Alexey Fomenkov, Giovanni Gadda, Richard D. Morgan, Andrei L. Osterman, Dmitry A. Rodionov, Irina A. Rodionova, Kenneth E. Rudd, Dieter Söll, James Spain, Shuang-yong Xu, Alex Bateman, Robert M. Blumenthal, J. Martin Bollinger, Woo-Suk Chang, Manuel Ferrer, Iddo Friedberg, Michael Y. Galperin, Julien Gobeill, Daniel Haft, John Hunt, Peter Karp, William Klimke, Carsten Krebs, Dana Macelis, Ramana Madupu, Maria J. Martin, Jeffrey H. Miller, Claire O’Donovan, Bernhard Palssøn, Patrick Ruch, Aaron Setterdahl, Granger Sutton, John Tate, Alexander Yakunin, Dmitri Tchigvintsev, Russell Greiner, David Horn, Kimmen Sjölander, Steven L. Salzberg, Dennis Vitkup, Stanley Letovsky, Daniel Segrè, Charles DeLisi, Richard J. Roberts, Martin Steffen, Simon Kasif

June 2013

July 11th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items


  • Castle Graduation Celebration 2013


Dr. Nancy Miller with Graduate Dr. Yani Toribio, Dr. Grace Zhao and Graduate Dr. Joy Tan


First Years; Dr. Yue Sun, Dr. Cathryn Byrne-Dugan, Dr. Dhay Kamel and Dr. Anita Malek


Dr. Robert Pistey playing some soft music and resident Dr. Dana Semmel enjoying


  • Congratulations Graduating Resident, Dr. Josenia Tan who won the very first Robert Foley, MBA, Award. This honor will be given annually to a resident or fellow who “demonstrates the qualities that Mr. Foley brought to work every day.” This being the inaugural year of the prize Mr. Foley’s family was invited to the Castle Graduation Dinner.


    Dr. Joy Tan receiving the first Annual Robert Foley, MBA, Award from Department Chair, Dr. Daniel Remick and Dr. Chris Andry cheering her on.

  • Congratulations on passing the Qualifying Exams!
    • Jessica Allen
    • Mostafa Belghasem
    • Melody Lun
    • Caitlin Miller
    • Jacquelyn Sikora
    • Jason Sutin
    • Thank you to all faculty members who assisted with the qualifying exams, with a SPECIAL Thank You Dr. Barbara Slack and the Qualifying Exam Committee
  • The Scientific Steering Committee of the XXIVth International Society on Thrombosis and Haemostasis (ISTH in Amsterdam, Netherlands; June 29-July 4) has determined that the abstract from the Kurosawa Lab “is likely to have an immediate and important impact on the practice of clinical medicine” and will be included in the ISTH publication with MD Conference Express which is a peer-reviewed meeting highlights report. This late-breaking abstract presented by Dr. Shinichiro Kurosawa is entitled:  “Complement is not activated in nonhuman primates during development of hemolytic uremic syndrome and thrombotic microangiopathy induced by E.coli Shiga toxins” by authors B.C. Lee, C.L. Mayer, C.S. Leibowitz, D.J. Stearns-Kurosawa, S. Kurosawa.
  • Dr. Ivana Delalle gave a platform presentation “Deregulation of Exosomal and Cellular microRNA in Bipolar Disorder,” American Association of Neuropathologists Meeting; Charleston, South Carolina  on June 22, 2013
  • Dominic Beal , PhD, successfully defended his thesis “Role of Macrophages in Cockroach Allergen Induced Asthma” on Tuesday, June 18th
  • The Hematology Lab (Renee Nutting, Daoreuang Pongvongkeo, and John Lee) has validated lupus anticoagulant testing on the in-house automated coagulation platform.  All lupus anticoagulant testing from now on will be performed in-house.
  • Dr. Carmen Sarita-Reyes was the guest lecturer of the “Dr. Manuel Felipe Pimentel Imbert Lecture” at her alma mater Universidad Nacional Pedro Henriquez Ureña School of Medicine on June 18th 2013 in Santo Domingo, Dominican Republic. The title of her lecture was “Pediatric Pathology Clinical and Surgical Management”.

Sarita.ReyesSpeakingatHerAlmaMater.Spring2013.DSC_0110 (2)

Sarita.Reyes.AlmaMaterwithPresentation.Spring2013.DSC_0149 (2)


  • Nick Woolf, MD/PhD student in Nader Rahimi’s laboratory has been awarded a full fellowship from the Center for Nanoscience and Nanobiotechnology,  Boston University for his project entitled “The Role of IGPR-1 in Tumor Growth and Progression”
  • Zachary Hunter, PhD candidate was an invited speaker at the 2013 International Waldenström’s Macroglobulinemia Foundation Educational Forum; “The Genomic Landscape of WM” May 17-19, San Diego, California
  • Zach Hunter also gave an oral presentation “Recurring Activating Mutations and Somatic Deletions Revealed Through Whole Genome Sequencing in WALDENSTRÖM’S MACROGLOBULINEMIA” at the12th International Conference on Malignant Lymphoma June 19-22, Lugano, Switzerland
  • Dr. Carmen Sarita-Reyes gave a lecture on “Pediatric Pathology: Clinical-Pathologic Cases” at Robert Reid Cabral Children’s Hospital, Santo Domingo, Dominican Republic on June 25th 2013

Publications: ACCEPTED:

  • Liling Zeng, Ming Bai, Amit K. Mittal, Wassim El-Jouni, Jing Zhou, David M. Cohen, Mina I. Zhou, Herbert T. Cohen: Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal-cell carcinoma.  Cancer Research 2013 (in press)
  • Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Nader Rahimi. Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGFR-2. Accepted for publication in the Journal of Biological Chemistry


Publications: PUBLISHED:

  • Nicholas J. DeNunzio & Lija Joseph & Roxane Handal & Ankit Agarwal & Divya Ahuja & Ariel E. Hirsch. Devising the Optimal Preclinical Oncology Curriculum for Undergraduate Medical Students in the United States. J Canc Educ (2013) 28:228–236 DOI 10.1007/s13187-012-0442-0
  • Vipul Chitalia, Sowmya Shivanna, Jordi Martorell, Rosana Meyer, Elazer Edelman, and Nader Rahimi.  c-Cbl, a ubiquitin E3 ligase that targets active β-catenin – A novel layer of Wnt regulation Journal of Biol. Chem. jbc.M113.473801. First Published on June 6, 2013, doi:10.1074/jbc.M113.473801
  • Azadzoi KM and Siroky MB. Mechanism of lower urinary tract symptoms in pelvic ischemia. J Biochem & Pharmacol Res: 1: 64-74, 2013, 2013
  • Treon, S. P., & Hunter, Z. R. (2013). A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood, 121(22), 4434–4436. doi:10.1182/blood-2013-04-494849

May 2013

June 7th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –


  • 36th ANNUAL CONFERENCE ON SHOCK, June 1 – 4, 2013, San Diego, California:
    • PhD Candidates Evan Chiswick, Dominic Beal, and Surgical Resident/Researcher Juan Rodolfo Mella Remick Lab  will present a poster; “Too Zealous Too Soon: The Shift from Hyper to Hypo Reactive Phagocytes in Polymicrobial Sepsis”
    • Chad Mayer, MD/PhD candidate, Kurosawa Lab, has an abstract accepted for ORAL presentation at the 2013 Shock Society meetings in San Diego.  His abstract is entitled” DAMPs and endothelial dysfunction in a mouse model of Stx2 toxemia” by authors CL Mayer, CS Leibowitz, S Kurosawa, DJ Stearns-Kurosawa.
    • Caitlin Leibowitz, PhD candidate, Kurosawa Lab, has an abstract accepted for POSTER presentation at the 2013 Shock Society meeting in San Diego.  Her abstract is entitled “Neutropenia delays acute kidney injury in a murine Stx2 toxemia model” by authors C.S. Leibowitz, C.L. Mayer, S. Kurosawa, D.J. Stearns-Kurosawa.
    • Daniel Remick, M.D. was invited to give talk “Oxidante Regulation of Chemokine Gene Expression”
    • Daniel Remick, M.D. helped organize a panel discussion by all 5 level 1 trauma centers in the city of  Boston to discuss the trauma center’s experience with the Marathon Day bombings.
    • Daniel Remick, M.D., chaired the International Relations Committee and served as a member of council and Past-President of the Society.
    • Daniel Remick, M.D., organized the annual fun run, always a highlight of the meeting.
  • From the Remick Lab: PhD Candidate Evan Chiswick and Surgical Resident Juan Rodolfo Mella each received a Travel Award to attend next month’s SHOCK Conference in San Diego, California
  • David Stepien , MD/PhD, successfully defended his thesis “The Immune Response to Bacterial Pneumonia Following Traumatic Brain Injury” on Thursday, May 16th
  • MD/PhD Candidate Melody Lun has been awarded a grant from the American Federation for Aging Research (AFAR). The official title of the scholarship is “Glenn/AFAR Scholarship for Research in the Biology of Aging”
  • PhD Candidate Mostafa Belghasem received a fellowship (travel award) to attend the Intravital Microscopy Workshop at Indiana University Medical Center; this workshop was the week of May 5th
  • Barb Nikolajczyk, PhD was an invited to present at several events for May 2013:
    • Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes, 2013.
    • University of California at Los Angeles, Los Angeles, CA, Human B lymphocytes are master regulators of
    • American Association of Immunologists Annual Meeting, Honolulu, HI, Lymphocyte functions in type 2 diabetes, 2013.
    • University of Chicago, Department of Pathology. B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013.
  • A recent manuscript from the Kurosawa and Henderson labs, in collaboration with a group at Texas A&M was discussed in the May issue of the Kidney International Journal Club (Kidney International (2013) 83, 775–776. doi:10.1038/ki.2013.116).  This journal highlights the latest research from across a wide spectrum of journals in fields relevant to renal research.  The Kurosawa-Henderson manuscript identified differences in renal pathology elicited by toxins from enterohemorrhagic E.coli, a food and water-born pathogen, and supports the notion that therapeutic targeting of both bacterial toxins is of value.
  • Nancy S. Miller, MD lead a presentation and audience interactive session at the AACC Trimark Infectious Disease Conference on May 31, 2013 in Randolph, MA. “Point of Care Meets Microbiology:  What we have, what we need, what is on the way?  Preparing for the next frontier of point-of-care” In collaboration with Jean Ahern, C(ASCP) POC Specialist at BMC.
  • Dr. Carmen Sarita –Reyes has been appointed a member of the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee. Dr. Sarita-Reyes will be attending her first meeting from May 28th – 31st 2013 in Chicago, Illinois.
  • Dr. Kazem Azadzoi presented a moderated poster entitled “Sleep apnea causes bladder oxidative stress and nocturia in rats” at the American Urological Association (AUA) annual meeting in San Diego
  • Dr. Kazem Azadzoi also presented a moderated poster entitled “Upregulation of P2X purinergic receptors in bladder oxidative stress augments smooth muscle contractions” at the American Urological Association (AUA) annual meeting in San Diego


Publications: ACCEPTED:

  • Han-Pil Choi, Silvia Juarez, Sergio Ciordia, Marisol Fernandez, Rafael Bargiela, Juan P. Albar, Varun Mazumdar, Brian P. Anton, Simon Kasif, Manuel Ferrer, Martin Steffen. “Biochemical Characterization Of Hypothetical Proteins From Helicobacter pylori” PLoS One

In this paper, we present here the biochemical analysis of six proteins from Helicobacter pylori ATCC 26695. The functional characterization of Open Reading Frames (ORFs) from sequenced genomes remains a bottleneck in our effort to understand microbial biology. In particular, the functional characterization of proteins with only remote sequence homology to known proteins can be challenging, as there may be few clues to guide initial experiments. We provide a path towards this problem using affinity enrichment of proteins from cell lysates, and a global perspective of protein function as provided by COMBREX.

  • Resident Anita Deshpande, PGY-2, USCAP poster presentation held in Baltimore March 2013 on “Leiomyoma of the Gastrointestinal tract with Interstitial cells of Cajal: A mimic of gastrointestinal stromal tumor” has been accepted by American Journal of Surgical Pathology for publication.
  • Smith, B., S. Rozelle, J. Ubellacker, A. Parks, A. Leung, S. Nah, D. French, P. Gadue, S. Monti, D. Chui, M. Steinberg, D. Kotton, G. Mostoslavsky, D. Sherr, and G. Murphy. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood In Press
  • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology In Press
  • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. In Press
  • Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ*, Kurosawa S.* Quiescent complement in nonhuman primates during E.coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy.  Blood, 2013. (impact factor 9.8)


Publications: PUBLISHED:

  • Stearns-Kurosawa DJ, Oh S-Y, Cherla RP, Lee M-S, Tesh VL, Papin J, Henderson J, Kurosawa S.  Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic E.coli Shiga toxins in non-human primate models of hemolytic uremic syndrome.  American Journal of Pathology, 182(4):1227-38, 2013

April 2013

May 1st, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items



  • Our own, Ryan Gould, Pathology Assistant, has been chosen to receive one of this year’s Boston Medical

    Ryan Gould being notified by the “Be Exceptional” Committee of his award

    Ryan Gould being notified by the “Be Exceptional” Committee of his award

    Center’s “Be Exceptional Awards!” Bravo Ryan! Ryan was notified of the award on April 24th along with an Edible Arrangements, balloons and an invitation to the May 8th “Be Exceptional Awards” Ceremony

  • The ASIP 2013 Annual Meeting at Experimental Biology; Boston, MA, April 20-24:
    • Dr. Daniel Remick organized a workshop for the American Society of Investigative Pathology at the 2013 Experimental Biology Meeting. The workshop was titled “We can’t all be PI’s: Preparing Graduate Students for Alternative Career Paths”. More than 700 attendees signed up for the workshop although there were actually only 80 attendees. Typically only 15 to 20 participants come to the workshop so there was significant interest in the topic. Additional information may be found at:
    • Dr. Michael Greene, recent PhD, presented a poster entitled “”The circulating molecular chaperone clusterin interacts with amyloidogenic transthyretin oligomers and modulates amyloid formation”
    • PhD Candidate, Jacquelyn Sikora in Dr. Connors Lab, gave a poster, “Single nucleotide polymorphisms in the 3′ untranslated and near gene regions of transthyretin may play a role in senile systemic amyloidosis.” This poster is in the ASIP Translational Research in Human and Animal Models session, Monday April 22
    • Dr. Maria Panchenko and Post-doc Dr. Nirodhini Siriwardana presented the poster “Histone Acetyl Transferase (HAT) HBO1 and PHD Finger Protein 17 (PHF17/JADE1) in Epithelial Cell Regeneration” at “Experimental Biology”
  • Celebrating Lab Week!! April 22-26 is Medical Laboratory Professionals Week! It’s that time of year again; time to recognize and celebrate the dedication, hard work and excellence of our laboratory team! Click here for video

BMC Lab week

Linwood Beverly, Jean Hilaire

BMC Lab week 2

Janet Means, Neil O’Neill, Graziella Haddad, Diane Mullen

BMC Lab Week 3

Kevin Redmond of Abbott, Kathy Harkins, Charline Mack, Sarkis Chekijian of Abbott

  • Nancy S. Miller, MD presented the following at the New England Microbiology Medical Directors Meeting, April 24, 2013: “Developing a protocol for Fecal Microbiota Transplant: One institution’s story”
  • Dr. Karen Quillen was an invited speaker at the Massachusetts Association of Blood Banks Annual Spring Seminar in April. Title of talk was “Back to basics, and back to the future”


Publications: ACCEPTED:

  • Kendra N. Iskander, Marcin F. Osuchowski, Deborah J. Stearns-Kurosawa, Shinichiro Kurosawa, David Stepien, Catherine Valentine and Daniel G. Remick; Sepsis – Multiple Abnormalities, Heterogeneous Responses, Evolving Understanding; accepted April 29, 2013, Physiological Reviews.  This article was just accepted for publication in Physiological Reviews, which has an impact factor of 27. Physiological Reviews is ranked #5 among all biomedical scientific journals.


Publications: PUBLISHED:

  • Qu X, Li M, Liu HJ, Xiang Y, Tan Y, Weber HC, Qin XQ. Role of bombesin receptor activated protein in the antigen presentation by human bronchial epithelial cells. J Cell Biochem. 2013 Jan;114(1):238-44.
  • Weber HC. Medical treatment of neuroendocrine tumours. Curr Opin Endocrinol Diabetes Obes 2013;20:27-31.
  • Hermos JA, Altincatal A, H. Christian Weber, Grotzinger K, Smoot KJ, Cho K, Gagnon DR, Lawler EV. Thrombocytopenia and Bleeding in Veterans with Non-hepatitis C-related Chronic Liver Disease. Dig Dis Sci. 2013 Feb;58(2):562-73