June 2012

July 2nd, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • Castle Graduation Celebration 2012
Castle2012.Kristina.Chris.MaryJo.P1000302[1]
New PhD Graduate Dr. Kristina Perry, Committee Member and Co-Director Graduate Program, Dr. Chris Andry and Kristina’s Committee Chair, Dr. Mary-Jo Murnane
Castle-6 New PhDs: Dr. Jacqueline Bouchard, Dr. Madhu Bogdan, Dr. Kristina Perry and Dr. Srimathi Srinivasan
Castle-8 Graduate Dr. Srimathi Srinivasan and her mentor Dr. Nader Rahimi
  • Congratulations on passing the Qualifying Exams!
    • Caitlin Leibowitz
    • Zachary Hunter
    • Chad Mayer
    • Nicole Stauffer
    • Martin Steinbuck
    • Thank you to all faculty members who assisted with the qualifying exams, with a SPECIAL Thank You Dr. Bohdana Burke
  • Barb Nikolajczyk presented her team’s work at the American Diabetes Association Annual Meeting June 2012.  The title of the work was “B Lymphocytes are Master Regulators of a Pro-inflammatory T Cell Balance in Obesity and Glucose Intolerance”. This work has also been selected as a plenary oral presentation for The Obesity Society Annual meeting in Sept. 2012 in San Antonio TX. Dr. Nikolajczyk has also been invited as a panel member at an Obesity Society Annual Meeting Pre-conference Workshop on Adipocyte Metabolism
  • Barb Nikolajczyk also presented “B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance ” as an invited speaker at the Univ. of Pennsylvania Immmunology seminar series in June, 2012
  • David Stepien, MD/PhD candidate in the Remick Lab was invited to give an oral presentation at the 35th Annual Conference on Shock entitled: “Traumatic Brain Injury Enhances the Pulmonary Immune Response to Pseudomonas aeruginosa Pneumonia” on June 10th in Miami Beach, FL. David also received a Travel Award from the Shock Society to attend the conference
  • Welcome Summer Students in the Kurosawa Lab:
    • Jonathan Greenbaum, a BU undergrad from the UROP program
    • Conor Johnson, a high school student from the BU RISE program
    • Ben Lee, a Pathology Master’s student
    • Erin Kelley, an undergrad from Bates College in Maine
  • Caitlin Miller, 2nd year PhD candidate has recently been accepted into the ITP Program. She will be doing her thesis work in Rahm Gumuluru’s Lab

 

Publications: ACCEPTED

  • Anthony Makkinje, Pierre Vanden Borre, Richard I. Near, Prayag S. Patel and Adam Lerner. “Breast cancer anti-estrogen resistance 3 (BCAR3) augments binding of the c-Src SH3domain to Crk-associated substrate (p130Cas)” The Journal of Biological Chemistry
  • Girnius S, Dember L and Lerner A. “Diabetes insipidus as presenting manifestation of Waldenstrom’s macroglobulinemia” Journal of Hematology

May 2012

June 1st, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • Our own Chris Andry, MPhil, PhD and his colleague in Cancer Care Services, Robyn Souza, RN were recognized by the Otolaryngology Department for their contributions to the Head and Neck Cancer Service at BMC. The award is named after Elaine Ullian, the former CEO of Boston Medical Center.
  • Dr. Barbara Slack is very happy to announce this year’s Russek Award recipients in the Department of Pathology:
    • First Prize- Jacqueline Bouchard, PhD (Advisor: Daniel Remick)
    • Second Prize- Patricia Kao, PhD Candidate (Advisor: Ivana Delalle)
    • Honorable Mention- Srimathi Srinivasan, PhD (Advisor: Nader Rahimi)
    • Congratulations to the awardees, and thanks to everyone who submitted abstracts for the poster session. This year’s Russek Day took place on May 11th in the Hiebert Lounge (L building, 14th floor) with many faculty and students attending!
  • Kurosawa Lab Graduate students Caitlin Leibowitz, PhD Candidate and Chad Mayer, MD/PhD Candidate contributed data to two abstracts accepted at international conferences:
    • The 7th Congress of the International Federation of Shock Societies and 35th Annual Conference on Shock, The Shock Society; Miami, Florida, June 9-13, 2012; DJ Stearns-Kurosawa, Chad Mayer, Caitlin Leibowitz, Shinichiro Kurosawa. “EHEC bacterial toxins-1 and-2 are synergistic in non-human primates”
    • The 58th Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis; Liverpool, England, United Kingdom, June 27-30, 2012. D. Stearns-Kurosawa, C Leibowitz, C Mayer, S Kurosawa. “Developing Animal Models of Hemolytic Uremic Syndrome”
  • The Kurosawa Lab collaboration with Dr. Heather Hardway at BU Department of Mathematics and Statistics resulted in two abstracts accepted at international conferences:
    • The 7th Congress of the International Federation of Shock Societies and 35th Annual Conference on Shock, The Shock Society; Miami, Florida, June 9-13, 2012. Heather Hardway, DJ Stearns-Kurosawa, Shinichiro Kurosawa; “Monitoring Host Improvement or Decline Over Time Using Grouped Data Sets”
    • The 58th Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis; Liverpool, England, United Kingdom, June 27-30, 2012. H Hardway, D Stearns-Kurosawa, S Kurosawa.  “Modeling Physiological and Cytokine Data to Predict Outcome”
  • Chad Mayer, MD/PhD Candidate in the Kurosawa Lab received a training grant from the Cardiovascular Institute on the BUSM Campus
  • Dr. Susan Winandy served on  the Cellular and Molecular Biology-B NIH study section in May
  • Alex Gallant, 3rd year medical student going into Pathology has received the American Society for Clinical Pathology Medical Student Achievement Award for Academic Excellence and Achievement in Pathology. There are only 10 medical students in the country who receive this award each year. Included in the award is an Amazon Kindle Fire and the second edition of the Handbook of Clinical Pathology
  • Nancy S. Miller, MD presented “Prudent Culture Practice & Challenges:  When to give an inch and when to go the mile”, as an invited speaker at the 28th Annual Meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID), May 21-23, in Boxborough, Massachusetts
  • The Cadaver Biopsy Project members presented two posters at the John McCahan Medical Education Day, on May 23 at Boston University. Congratulations to medical students Hillary Johnston Cox, Anna Eisenstein, Lev Vaisman, Alexander Gallan and mentors Dr. Carl O’Hara and Dr. Lija Joseph
  • Graduation 2012
Graduation2012.Photo3.Jackie.Dan.Graduation Graduation2012.Photo2.Madhu.Supraja.Kristina.IMAG0200 Graduation2012.Photo4.Jackie.Madhu.Celebrating.0002259-R1-017-7 Graduation2012.Photo1.Sri.Madhu.Jackie.IMAG0203
Dr. Daniel Remick, Department Chair and his graduating Lab Member Dr. Jacqueline Bouchard New PhDs: Dr. Madhu Bogdan, Dr. Supraja Narasimhan and Dr. Kristina Perry Dr. Jacqueline Bouchard and Dr. Madhu Bogdan celebrating graduation! New PhDs: Dr. Srimathi Srinivasan, Dr. Madhu Bogdan and Dr. Jacqueline Bouchard

 

Publications: PUBLISHED

  • Dr. Lija Joseph has a chapter (Non neoplastic disorders of platelets) that she has authored just published by Wiley in Non-neoplastic hematopathology and infections, . The chapter also acknowledges one of the members of our hematology lab at BMC, Kathy White.

 

Publications: ACCEPTED

  • Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I: “Increased Expression of TrkB and Capzb2 Accompanies Preserved Cognitive Status in Early Alzheimer’s Disease Pathology” Journal of Neuropathology and Experimental Neurology
  • Ghosh CC, Mukherjee A, David S, Stearns-Kurosawa D, Kurosawa S, Parikh SM.  “Impaired Function of the Tie-2 Receptor Contributes to Vascular Leakage and Lethality in Anthrax” Proc National Academy of Science USA, in press 2012
  • Bouchard, J.C, Kim, J., Beal, D.R., Vaickus, L.J., Craciun, F.L. and Remick, D.G. “Acute Oral Ethanol Exposure Triggers Asthma In Cockroach-Allergen Sensitized Mice” in press, American  Journal of Pathology

April 2012

May 2nd, 2012

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Daniel Remick, MD, has been elected as the Treasurer of the Faculty Practice Foundation of Boston Medical Center
  • Dr. Daniel Remick is pleased to report that Dr. Carmen Sarita-Reyes, co-director of the Dental School pathology course, has been appointed to the Joint Commission on National Dental Examinations (JCNDE) National Microbiology-Pathology Test Construction Committee for 2013. This appointment will allow the department of pathology to provide direct input into the formulation of test questions and will ensure that our Dental students receive instruction tailored to their specific needs. As best as we can determine, this is the first time a Boston University pathologist has been appointed to this national body.
  • Congratulations to Jacqueline Bouchard, PhD, who successfully defended her thesis “Immunological Mechanisms of Alcohol-Exacerbated Asthma” on Wednesday, April 4th
  • Zach Hunter, PhD Candidate presented his work at the Dana-Farber Hematologic Neoplasia & Immunologic Therapies Seminar Series; “Somatic Variants Revealed by Whole Genome Sequencing in Waldenstrom’s Macroglobulinemia” on Wednesday, April 4th
  • Zach Hunter, PhD Candidate also presented a poster at the American Society of Clinical Oncology in Chicago on June 4th, and he is its first author; “Use of Whole Genome Sequencing to Identify Highly Recurrent Somatic Mutations in Waldenström’s Macroglobulinemia” Zachary R Hunter, Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Christina Tripsas, Robert J Manning, Christopher J Patterson, Patricia S Sheehy, Steven P. Treon
  • Joann Crain, Lab Medicine’s Point of Care Specialist, presented at the CLMA (Clinical Laboratory Management Association) Northeast Region Conference on April 10 in Boxboro MA on “Project Trust- An Overview of a Rapid HIV Testing Program”
  • Parul Agnihotri, PhD Candidate in the Winandy Lab will present an abstract entitled “Role of Ikaros in Foxo1-driven Gene Expression in CD4 T Cells” at the International Graduate Student Immunology Conference 2012 at Harvard University on April 27-28 2012
  • A poster by Resident Manisha Mehta, MD has been nominated for the “Member-in-training’ Award (MIT Award ) at the ARVO Conference (Association for Research in Vision and Ophthalmology) on May 8th, 2012 at Fort Lauderdale, Florida. Poster details: “PDCL3 Regulates Endothelial Cell Proliferation And Angiogenesis Through The Generation Of Functional VEGFR-2;” Manisha Mehta, Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Vipul Chitalia, Nora Laver, Nader Rahimi
  • April 30-May 4 is Lab Week; Happy First Anniversary in your new location Lab Medicine!!!

 

Publications: PUBLISHED

  • Fengxiu Ouyang, Margaret Parker, Sandra Cerda, Colleen Pearson, Lingling Fu, Matthew W. Gillman, Barry Zuckerman and Xiaobin Wang; “Placental Weight Mediates the Effects of Prenatal Factors on Fetal Growth: the Extent Differs by Preterm Status” Obesity April 2012
  • Marie E McDonnell, Lisa M Ganley-Leal, Ankeeta Mehta, Sherman J Bigornia, Melanie Mott, Qasim Rehman, Melissa G Farb, Donald T Hess, Lija Joseph, Noyan Gokce, Caroline M Apovian; “B Lymphocytes in Human Subcutaneous Adipose Crown-Like Structures” Obesity (impact factor: 3.37). 03/2012; DOI: 10.1038/oby.2012.54
  • Tan JN, Burke PA, Agarwal SK, Mantilla-Rey N, Quillen K; “A Massive Transfusion Protocol Incorporating a Higher FFP/RBC Ratio Is Associated With Decreased Use of Recombinant Activated Factor VII in Trauma Patients.” American Journal of Clinical Pathology 2012 Apr;137(4):566-71. PubMed PMID: 22431532.

 

Publications: ACCEPTED

  • Barbara S. Nikolajczyk, Madhumita Jagannathan-Bogdan and Gerald V. Denis. “The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point” Immunological Reviews 2012
  • Nancy S. Miller, Belinda Yen-Lieberman, Melinda D. Poulter, Yi-Wei Tang, and Paul A. Granato; “Comparative Clinical Evaluation of the IsoAmp® HSV Assay with ELVIS® HSV Culture/ID/typing Test System for the Detection of Herpes Simplex Virus in Genital and Oral Lesions” Journal of Clinical Virology
  • Josenia N.M. Tan, Martin H. Kroll, Carl J. O’Hara, Peter C. Everett, Evrim Erdogan; “Gamma Heavy Chain Disease in a Patient with Underlying Lymphoplasmacytic Lymphoma of the Thyroid; Report of a Case and Comparison with Other Reported Cases with Thyroid Involvement” Clinica Chimica Acta

 

 

 

 

 

March 2012

April 4th, 2012

Pathology & Laboratory Medicine News Items

 

Announcements:

  • The Nikolajczyk Lab’s work, “B Lymphocytes are Master Regulators of a Pro-inflammatory T Cell Balance in Obesity and Glucose Intolerance” was done in collaboration with the Denis Lab and has been selected for:
    • An oral presentation at the American Association of Immunologists Annual Meeting in Boston inMay. Anna Belkina will be presenting.
    • An oral presentation at the American Diabetes Association Annual Meeting in Philadelphia in June. Dr.Barbara Nikolajczyk will be presenting.
  • Dr. Daniel Remick presented the annual John F. Sander and Nancy K. Dunkel Lecture at Michigan State University, “The Inflammatory Response in Sepsis” on March 1st
  • MSU Students Listening to Dr. Remick’s Lecture
    MSU Students Listening to Dr. Remick’s Lecture

     

  • The Faculty Practice Plan has been re-organized with a new board of directors. Dr. Remick was elected to a 2year term to serve on the Board of Directors. He was also elected to the finance committee of the Faculty Practice Plan and was appointed to the CARTS group to negotiate with Boston Medical Center for purchasedphysician services. CARTS is Clinical Administrative Research Teaching and Strategic components of the physician services provided to BMC
  • Connors Lab members, Michael Greene, PhD candidate, Clarissa Koch, PhD candidate, and Dr. Lawreen Connors will be attending and presenting at the XIIIth International Symposium on Amyloidosis “From misfolded proteins to well-designed treatment” from May 6-10, 2012 at University Medical Center in Groningen, The Netherlands.
  • Clarissa Koch, PhD candidate will be presenting her poster, “Cardiotoxicity of pre-fibrillar transthyretin oligomers and attenuation by doxycycline” at the 13th International Symposium on Amyloidosis conference in Groningen in May 2012
  • Also Dr. Connors is so proud to tell you that Michael and Clarissa been granted Travel Awards from The Amyloidosis Foundation. Bravo Mike & Clarissa!
  • Dr. Lawreen Connors will be giving an oral presentation entitled “Senile Systemic Amyloidosis: a large cohort study detailing clinical features, laboratory results and survival” at the symposium in Plenary Session 8: Biology, clinics and prognosis in ATTR amyloidosis. This research was done in collaboration with the Denis Lab
  • Dr. Daniel Remick chaired an NIH special emphasis panel to review a Trauma Center grant. He also served on a total of 5 NIH study sections between December 2011 and March, 2012
  • Dr. Carmen Sarita-Reyes was a Program Chair for the Program Chairs Workshops presented at the Society for Pediatric Pathology 2012, Annual Meeting Program Chairs Spring Meeting in Vancouver, BC, Canada March 17-18, 2012
  • Congratulations are in Order!!!
    • Srimathi Srinivasan, PhD, successfully defended her thesis “MOLECULAR REGULATION OF VEGFR-2 EXPRESSION AND ACTIVATION IN ENDOTHELIAL CELLS” on Thursday, March 22nd
    • Edward Hartsough, PhD, successfully defended his thesis “Molecular Regulation of VEGFR-2 Function and Expression through Post-Translational Modifications” on Monday, March 26th
    • Kristina Perry, PhD, successfully defended her thesis “COPY NUMBER ABERRATIONS AND INTEGRATION OF GENOMIC ARRAY DATA IN PREINVASIVE BREAST CANCER” on Monday, March 26th
  • Dr. Carmen Sarita-Reyes was a panel member at The Office of Diversity of Multicultural Affairs, Latino at BUMC – A Conversation. The goal of this activity was to have a candid dialogue on the challenges and successes of Latinos at BUMC. The anticipation was that this exchange would greatly benefit students, residents, and faculty following the footsteps of our distinguished panelists. Individuals from all ethnicities and cultures were strongly encouraged to attend. The panel discussion was moderated by Assistant Dean Dr. Samantha Kaplan. Panelists included: Carlos Kase, MD, Professor and Chair of Neurology; Jane Mendez, MD, Associate Professor of Surgery; Gerardo Rodriguez, MD, Assistant Professor of Anesthesiology and Carmen D. Sarita-Reyes, MD, Assistant Professor of Pathology and Laboratory Medicine
  • Nancy S. Miller, MD has been invited to be a featured speaker at the “Culture-Independent Diagnostics Forum: Charting a Path for Public Health” to be held at the CDC in Atlanta, April 2012. The forum is being organized by the U.S. Centers for Disease Control and Prevention (CDC), the Association of Public Health Laboratories (APHL), and the Council of State and Territorial Epidemiologists (CSTE), to address potentially serious emerging issues in the area of infectious disease surveillance caused by the use of culture independent methods in clinical diagnostic laboratories

 

Publications: PUBLISHED

  • BUSM authors (Ivana Delalle, MD, PhD and Patricia Kao, PhD candidate, Delalle Lab) contributed in the human brains analysis in this study that involved both mouse model and human tissue: For the first time in human post-mortem brain samples of patients at different stages of Alzheimer’s disease (AD), histone deacetylase (HDAC) 2 levels are shown to be elevated, suggesting that a epigenetic blockade of cognitive functions documented in mouse models of AD might be at play in the human brains inflicted by AD. This increase of HDAC2 leads to reduced histone acetylation of genes important for learning and memory, which show a concomitant decrease in expression resulting in impaired cognitive functioning. Link

 

Publications: ACCEPTED

  • Nader Rahimi, Kobra Rezazadeh, John E. Mahoney, Edward Hartsough, Rosana D Meyer. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Molecular Biology of the Cell, 2012
  • Jin L, Roehrl MHA, Xiao L, He X, Li H, Ge L, Shi B. Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin. Acta Crystallographica F, 2012
  • Jonathan S. Kingsbury, Thomas M. Laue, Susan F. Chase, and Lawreen H. Connors. Detection of high molecular weight amyloid serum protein complexes using Biological On-Line Tracer Sedimentation (BOLTS) Analytical Biochemistry

February 2012

February 29th, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • The feature article for the February CR Times, “Taking the Bite Out of the BARC: Getting Specimens from the BUMC Biospecimen Archive Research Core is Easier Than You Think!”  is about the BARC this month and was written by Dr. Robert Pistey, BARC Director,  Cheryl Spencer, MA, BARC Manager and an IRB senior analyst.
  • Dr. Michael O’Brien has a featured article in this week’s New England Journal of Medicine: Ann G. Zauber, Ph.D., Sidney J. Winawer, M.D., Michael J. O’Brien, M.D., M.P.H., Iris Lansdorp-Vogelaar, Ph.D., Marjolein van Ballegooijen, M.D., Ph.D., Benjamin F. Hankey, Sc.D., Weiji Shi, M.S., John H. Bond, M.D., Melvin Schapiro, M.D., Joel F. Panish, M.D., Edward T. Stewart, M.D., and Jerome D. Waye, M.D. Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths New England Journal of Medicine 2012; 366:687 – 696 February 23, 2012
  • Ben Brugmann, a PhD student in Dr. Susan Winandy’s Lab, was chosen for an oral presentation at the 99th Annual American Association of Immunologists (AAI) Meeting that will take place in Boston in May.
  • Dr. Susan Winandy was chosen to chair the “Hematopoietic Stem Cells and Lineage Fate Decisions” workshop session at the AAI Meeting
  • This past October Dean Karen Antman asked for anyone who had artistic science images to submit them for a Science Art Competition. David Stepien, MD/PhD candidate and Jacqueline Bouchard, PhD candidate in the Remick Lab submitted some images created from experiments in the lab. The selected winning images were unveiled recently at the medical student research forum; they will be displayed around campus and on the flat screen panels located in the medical school lobby. Attached are David’s 4 images and Jackie’s 2 images that won:
ImageJ=1.42q ImageJ=1.42q Stepien 1
Stepien 3 Stepien 2 Stepien 4

 

  • Tricia Kao, PhD candidate in the Delalle Lab presented a poster at the 40th Annual Meeting of the International Neuropsychological Society in Montreal, Canada, February 15-18, 2012, entitled “Exosomal miRNA profiling in prefrontal cortices of patients diagnosed with bipolar disorder and schizophrenia”, authored by Meredith G. Banigan, Patricia F. Kao, James Kozubek, Juan Medina, Joan Costa, Andrea Schmitt, Ivana Delalle and Charles R Vanderburg. This work is a result of our laboratory collaboration with Harvard NeuroDiscovery Center (Banigan, Vanderburg), UConn Genetics Dept (Kozubek), and Brain-Net Europe – an international organization of brain tissue depositories (Medina, Costa, Schmitt).
  • Resident Dr. Manisha Mehta’s poster got accepted for the “ARVO” (The Association for Research in Vision and Ophthalmology) Conference. This is an international conference to be held in Fort Lauderdale, Florida (May 6-10, 2012). Manisha will be presenting her poster on May 8th. Poster details:  “PDCL3 Regulates Endothelial Cell Proliferation And Angiogenesis Through The Generation Of Functional VEGFR-2”;  Manisha Mehta, Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Vipul Chitalia, Nora Laver, Nader Rahimi.
  • Kazem Azadzoi, MD has received a VA Merit Review grant award funded for 4 years to study the role of oxidative stress in bladder overactivity and lower urinary tract symptoms

 

Publications: PUBLISHED

  • McMillin DW, Jacobs HM, Delmore JE, Buon L, Hunter ZR, Monrose V, Yu J, Smith PG, Richardson PG, Anderson KC, Treon SP, Kung AL, Mitsiades CS. Molecular and cellular effects of NEDD8 activating enzyme (NAE) inhibition in myeloma. Molecular Cancer Ther. 2012 Jan 12
  • Ojha RP, Hanzis CA, Hunter ZR, Greenland S, Offutt-Powell TN, Manning RJ, Lewicki M, Brodsky PS, Ioakimidis L, Tripsas CK, Patterson CJ, Sheehy P, Singh KP, Treon SP.  Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: A preliminary study. Cancer Epidemiology. 2011 Nov 16
  • Hangun Kim,  Yongfeng He,  Ilhwan Yang, Yan Zeng, Yonghee Kim, Young-Woo Seo, Mary Jo Murnane, Chaeyong Jung, Jae-Hyuk Lee,  Jeong-Joon Min, Dong-Deuk Kwon,  Kyung Keun Kim, Qun Lu, Kwonseop Kim.    δ-Catenin promotes E-cadherin processing and activates β-catenin-mediated signaling: Implications on human prostate cancer progression. Biochimica et Biophysica Acta 1822 (2012) 509–521. Interesting to note: Kwonseop Kim was one of Dr. Murnane’s PhD students back in the 1990’s
  • Carmen D. Sarita-Reyes, M. Alba Greco, German C. Steiner. Mesenchymal–Epithelial Differentiation of Adamantinoma of Long Bones: An Immunohistochemical and Ultrastructural Study. Ultrastructural Pathology February 2012, Vol. 36, No. 1 , Pages 23-30 (doi:10.3109/01913123.2011.631725)
  • Dave Sherr, PhD just had a commentary accepted in Nature Immunology volume 13 number 2 FEBRUARY 2012:

January 2012

February 1st, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • Boston Magazine has released its annual Top Docs issue and our own Dr. Antonio de las Morenas was once again on the list of “Top Docs” Congratulations Dr. de las Morenas
  • Dr. Ivana Delalle was an invited lecturer December 15, 2011 at the European Neuroscience Institute at Goettingen University, Germany. Her presentation was I entitled: “Identifying modulators of brain reserve and neuropathology in cognitive and mood disorders”
  • On January 3 Dr. Ivana Delalle became a Member of the Program Committee for the American Association of Neuropathologists Meeting in Chicago, June 2012
  • Dr. Michael Roehrl will be an invited speaker on “Integrating Proteomics and Genomics into Next Gen Systems Pathology” to be given at Cambridge Healthtech Institute’s Eighth Annual Biomarker World Congress in Philadelphia, PA (May 21-23, 2012)
  • Martin Steffen, PhD was interviewed about the role of phosphorylation in cancer and its treatment by OncLive.
  • Dr. Catherine Valentine has been awarded the ‘Mentored Clinical Scientist Development Award’ (KO8) entitled ‘Adenosine and TLR regulation of costimulatory molecule expression in sepsis’ awarded by the NIH for 5 years
  • ACCEPTED to USCAP 2012: USCAP 2012 conference is being  held at the Vancouver Convention Center, Vancouver, Canada from March 17-23: One of our residents, Manisha Mehta, MD has a poster to be presented on March 21st: “Identification of IGPR-1 as a Novel Cell Adhesion Molecule Involved in Tumor Growth and Angiogenesis” Manisha Mehta, Rosana D Meyer, John E. Mahoney,  Kobra  Rezazadeh, Nader Rahimi

 

Publications: PUBLISHED

  • Qin, X., Qu, X., Coy, D., and Weber, H. C.: A Novel Selective Human Bombesin Receptor Subtype-3 Agonist Mediates CREB Phosphorylation and Transactivation. Journal of Moecular lNeurosciences 2011; Nov 30. [Epub ahead of print]
  • Ishita Deb Majumdar, Arvind Devanabanda, Benjamin Fox, Jacob Schwartzman, Huan Cong, John A. Porco, Jr., and H. Christian Weber: Synthetic Cyclohexenyl Chalcone Natural Products Possess Cytotoxic Activities Against Human Prostate Cancer Cells and Inhibit Cysteine Cathepsins in vitro. BBRC 2011; 416: 397-402
  • Ishita Deb Majumdar and H. Christian Weber: Appetite-modifying effects of bombesin receptor subtype-3 agonists.  In: “The Handbook of Experimental Pharmacology” Volume 209; Appetite Control. Editor Hans-Georg Joost. Springer-Verlag Berlin Heidelberg 2012 (in press)
  • Ishita Deb Majumdar and H. Christian Weber: Biology and Pharmacology of Bombesin Receptor Subtype-3. Current Opinions in Endocrinology, Diabetes & Obesity 2012: 19(1):3-7
  • H. Christian Weber: Gastrointestinal Regulatory Peptides. Current Opinions in Endocrinology, Diabetes & Obesity 2012 :19(1):1-2
  • Hall NH, Conley K, Berry C, Farina L, Sigler L, Wellehan JF Jr, Roehrl MHA, Heard D.J Zoo “Computed tomography of granulomatous pneumonia with oxalosis in an American alligator (Alligator mississippiensis) associated with Metarhizium anisopliae var anisopliae.” Wildl Med. 2011 Dec;42(4):700-8
  • Jean-Bosco Tagne1, Sumeet Gupta2, Adam C. Gower3, Steven S. Shen4, Saaket Varma1, Meenakshi Lakshminarayanan1, Yuxia Cao1, Avrum Spira3,4, Thomas L. Volkert2, Maria I. Ramirez;  “Genome-Wide Analyses of Nkx2-1 Binding to Transcriptional Target Genes Uncover Novel Regulatory Patterns Conserved in Lung Development and Tumors” appeared in PLoS ONE on January 5th

 

Publications: Accepted

  • Johannes Gräff1,2,3, Ji-Song Guan1,2,3, Damien Rei1,2, Wen-Yuan Wang1,2,3, Krista M. Hennig3,4, Thomas J.F. Nieland3,4, Daniel M. Fass3,4, Patricia F.Kao5, Martin Kahn1, Nadine Joseph1,2,3, Stephen J. Haggarty3,4, Ivana Delalle5, and Li-Huei Tsai1,2,3,* “An epigenetic blockade of cognitive functions in the neurodegenerating brain” in Nature
  • Hernández-Pérez M, El-Hajahmad M, Massaro J, Mahalingam M. “Expression of gelatinases (MMP-2, MMP-9) and gelatinase activator (MMP-14) in actinic keratosis and in in situ and invasive squamous cell carcinoma.” (in press, American Journal of Dermatopathol, 2011)
  • Paniz-Mondolfi A, Talhari C, Sander Hoffmann L, Connor D, Talhari S, Bermudez A, Hernández-Pérez M, Van Bressem, MF. “Lobomycosis: An emerging disease in humans and delphinidae”  in press, Mycoses, 2011

December 2011

December 2nd, 2011

Pathology & Laboratory Medicine News Items

Announcements:

  • Boston Magazine has released its annual Top Docs issue and our own Dr. Antonio de las Morenas was once again on the list of “Top Docs” Congratulations Dr. de las Morenas
  • Dr. Michael Roehrl was an invited speaker on Ultra-Rapid Biobanking at the October 2011 Molecular Diagnostics for Personalized Medicine Conference in Hannover, Germany
  • Also Dr. Roehrl taught a new postgraduate course for pathologists on “Systems Pathology: An Introduction to Omic Approaches in Modern Personalize Medicine” for the American Society for Clinical Pathology (ASCP) at the Annual Meeting in Las Vegas in October 2011.
  • Dr. Roehrl will teach a related course at the next USCAP Meeting in Vancouver in March 2012
  • Dr. Michael Roehrl has just been re-elected as the IMG Delegate to the Massachusetts Medical Society (MMS) House of Delegates
  • Dr. Carl O’Hara gave the annual Stanley L. Robbins lecture to the New England Society of Pathologists on November 15th. This lecture is named in honor of Dr. Robbins, former Chair of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. O’Hara lecture “New Proposal for the Classification of Lung Adenocarcinoma: What Happened to BAC” was presented to a standing room only group of pathologists. After dinner Dr. O’Hara presented two cases of lung cancer to further illustrate how the changes in classification impact clinical care of the patients. There is tremendous symmetry with Dr. O’Hara giving the annual Robbins lecture, since he is also the recipient of the Stanley Robbins Teaching Award in 2011 from the Boston University School of Medicine.
  • Jacqueline Bouchard, PhD Candidate in the Remick Lab traveled to Loyola University Medical Center in Maywood, Illinois, for the Annual Alcohol and Immunology Research Interest Group (AIRIG) conference on November 18th, 2011.  Jackie gave both a poster and oral presentation of her work entitled “Ethanol Intoxication as a New Trigger for Atopic Asthma.”  Jackie also received a travel award funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to cover the entire cost of attendance.
  • Dr. Kendra Iskander, a surgical resident conducting research in the Remick Lab on a T32 Fellowship, was awarded a resident scholarship to attend the Society of Thoracic Surgeons meeting in Ft. Lauderdale this January.  It includes hotel, registration, and airfare.  The meeting should be good for networking and professional development.
  • Welcome to NEW FACES!
  • Nikolajczyk Lab: Dr. Jason DeFuria will be joining Barb Nikolajczyk’s lab Dec. 1 as a post-doctoral fellow and as a trainee of the Hematology Training Grant.  Jason got his PhD at Tufts and is an expert on obesity.
  • Panchenko Lab: Dr. Maria Panchenko has two new research technicians in the lab:
    • Joseph Haegele, recent graduate of Rensselaer Polytechnic Institute with degree in Chemistry
    • Sherry Blackmon, recent graduate of Bridgewater State University with degree in Molecular Biology
    • Both will be engaged in experimental research activities

 

Publications: PUBLISHED

  • Toribio Y, Roehrl MHA. The Nasolabial Cyst – A Non-Odontogenic Oral Cyst Related to Nasolacrimal Duct Epithelium. Archives of Pathology and Laboratory Medicine, November 2011

 

Publications: Accepted

  • Rahimi N. “Ubiquitin–Proteasome System Meets Angiogenesi” (Review). Molecular Cancer Therapeutics
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Pathology & Laboratory Medicine News Items – December 2011

n Announcements:

o Dr. Michael Roehrl was an invited speaker on Ultra-Rapid Biobanking at the October 2011 Molecular Diagnostics for Personalized Medicine Conference in Hannover, Germany

o Also Dr. Roehrl taught a new postgraduate course for pathologists on “Systems Pathology: An Introduction to Omic Approaches in Modern Personalize Medicine” for the American Society for Clinical Pathology (ASCP) at the Annual Meeting in Las Vegas in October 2011.

o Dr. Roehrl will teach a related course at the next USCAP Meeting in Vancouver in March 2012

o Dr. Michael Roehrl has just been re-elected as the IMG Delegate to the Massachusetts Medical Society (MMS) House of Delegates

o Dr. Carl O’Hara gave the annual Stanley L. Robbins lecture to the New England Society of Pathologists on November 15th. This lecture is named in honor of Dr. Robbins, former Chair of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. O’Hara lecture “New Proposal for the Classification of Lung Adenocarcinoma: What Happened to BAC” was presented to a standing room only group of pathologists. After dinner Dr. O’Hara presented two cases of lung cancer to further illustrate how the changes in classification impact clinical care of the patients. There is tremendous symmetry with Dr. O’Hara giving the annual Robbins lecture, since he is also the recipient of the Stanley Robbins Teaching Award in 2011 from the Boston University School of Medicine.

o Jacqueline Bouchard, PhD Candidate in the Remick Lab traveled to Loyola University Medical Center in Maywood, Illinois, for the Annual Alcohol and Immunology Research Interest Group (AIRIG) conference on November 18th, 2011.  Jackie gave both a poster and oral presentation of her work entitled “Ethanol Intoxication as a New Trigger for Atopic Asthma.”  Jackie also received a travel award funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to cover the entire cost of attendance.

o Dr. Kendra Iskander, a surgical resident conducting research in the Remick Lab on a T32 Fellowship, was awarded a resident scholarship to attend the Society of Thoracic Surgeons meeting in Ft. Lauderdale this January.  It includes hotel, registration, and airfare.  The meeting should be good for networking and professional development.

o Welcome to NEW FACES!

o Nikolajczyk Lab: Dr. Jason DeFuria will be joining Barb Nikolajczyk’s lab Dec. 1 as a post-doctoral fellow and as a trainee of the Hematology Training Grant.  Jason got his PhD at Tufts and is an expert on obesity.

o Panchenko Lab: Dr. Maria Panchenko has two new research technicians in the lab:

§ Joseph Haegele, recent graduate of Rensselaer Polytechnic Institute with degree in Chemistry

§ Sherry Blackmon, recent graduate of Bridgewater State University with degree in Molecular Biology

§ Both will be engaged in experimental research activities

n Publications: PUBLISHED

o Toribio Y, Roehrl MHA. The Nasolabial Cyst – A Non-Odontogenic Oral Cyst Related to Nasolacrimal Duct Epithelium. Archives of Pathology and Laboratory Medicine, November 2011

n Publications: Accepted

o Rahimi N. “Ubiquitin–Proteasome System Meets Angiogenesi” (Review). Molecular Cancer Therapeutics

November 2011

November 1st, 2011

Pathology & Laboratory Medicine News Items

Announcements:

  • Resident Marier Hernández-Pérez, MD had an abstract accepted for poster presentation at the Meeting of the 48th Annual Meeting of The American Society of Dermatopathologists (ASDP) in Seattle, WA in October. Marier Hernández-Pérez, MD; Mohamad El-hajahmad, MHCM; Meera Mahalingam, MD, PhD, FRCPath. “Expression of gelatinases (MMP-2, MMP-9) and gelatinase activator (MMP-14) in actinic keratosis and in in situ and invasive squamous cell carcinoma”
  • Our Cytopathology Fellowship has been approved by the ACGME until, September 2015
  • Madhu (Jangannathan) Bogdan PhD, successfully defended her thesis “CROSS-TALK BETWEEN ACTIVATED IMMUNE CELLS EXACERBATES INFLAMMATION IN TYPE 2 DIABETES” on October 28th
  • Dr. Carmen Sarita-Reyes presented a perinatology case at the Sociedad Latinoamericana de Patología Pediatrica (SLAPPE) on placental maturation defect on October 9th and 10th in Maceio, Brazil
  • Dr. Karen Quillen chaired a session at the AABB Annual Meeting in San Diego 10/23/11 entitled “Preventing hemolytic reactions from platelet transfusions: to screen or not to screen”
  • Resident Stephen Hammond, MD:
    • Won the Resident Leadership Award from the ASCP Annual Meeting 2011
    • Dr. Hammond presented his poster at the American Society of Clinical Pathology National Conference (ASCP) Meeting 2011: “Reducing Patient Waiting Times for Phlebotomy” Stephen Hammond, Janet Means, Jason Lumbrialdt, Martin Kroll.
    • Dr. Hammond also won Best Poster Award for poster referred to above at ASCP meeting 2011
Hammond - ASCP Leadership Award Stephen Hammond, MD (Leadership Award Recipient); Chris Coggbin, MD (Chair Resident Council ASCP); Bruce Alexander MD,(President ASCP) and Lili Lee, MD (Co- Leadership Award Recipient)
  • The Henderson Lab is going (en masse): Fangfang He, MD, Hui Chen, MD, Philip A Bondzie, Julie A. Tomolonis, Mostafa  Belghasem, MD Felita Agus, Joseph Coppola and Joel M. Henderson, MD, PhD; to the American Society of Nephrology Annual Meeting at “Kidney Week” in Philadelphia November 8-13 and some of the lab members will be presenting posters as mentioned in the October “New News”
  • Also from the Henderson Lab: Julie Tomolonis, a BU Senior in Cell and Molecular Biology, won a UROP FROG Award to support her Senior Honors Thesis work in the Renal Pathology Lab with Dr. Henerdon: “Cytotoxicity of amyloidogenic immunoglobulin light chains on human podocytes in culture”.  This project is a collaborative effort with Dr. Lawreen Connors and Dr. David Seldin at the Amyloid Center
  • Congratulations to Dr. Lija Joseph, her application to ICPI for matching funds for the Medical Student Interest Group Program has been approved
  • At the 2011 ASCP Annual Meeting/WASPaLM XXVI World Congress, October 19-22, Las Vegas, Dr. Martin Kroll gave a roundtable on “Interpreting Patient Results in the Presences of Biological Variation”, and a course on “Diagnostic Accuracy
  • Daniel G. Remick, MD was a visiting professor in the Department of Surgery at the University of Cincinnati and gave a talk “The Immunopathology of Traumatic Brain Injury”.  Dr. Remick was invited by the Vice Chair of Research, Alex Lentsch, Ph.D. to discuss and review their collaborative work to study the immunosuppressive effects of traumatic brain have already been initiated.
  • Daniel G. Remick, MD was a visiting professor in the Department of Microbiology and Immunology at Wayne State University and gave a presentation on “Alcohol and Asthma”. Dr. Remick was selected by the graduate students of Wayne State to be the visiting professor.
  • Nancy S. Miller, MD was co-convener for the symposium: “Evolving Technologies for Pathogen Detection” at the 46th Annual Region I Meeting of the American Society for Microbiology, October 26-27th 2011, Randolph, MA
  • Dr. Miller also presented a lecture, “Culture Shock! The Shift to New Technologies for In-Vitro Diagnostics in Clinical Microbiology” at the American Society for MicrobiologyIvana Delalle, MD, PhD just obtained a subaward in NIH RO1 “Epigenetics of Alzheimer’s Disease” grant initiated by Professor Tsai, Director of Picower Institute for Learning and Memory at MIT

Abstracts Accepted:

  • Patricia Kao, 4th year PhD candidate, has an abstract accepted for presentation at the 40th Annual Meeting of the International Neuropsychological Society in Montreal, Canada, February 15-18, 2012. Title: Exosomal miRNA profiling in prefrontal cortices of patients diagnosed with bipolar disorder and schizophrenia. Authors: Meredith Banigan, Patricia Kao, James Kozubek, Juan Medina, Joan Costa, Andrea Schmitt, Ivana Delalle, Charles Vanderburg

Publications: PUBLISHED

  • Maristela L Onozato1,2, Stephen Hammond3, Mark Merren2,  Yukako Yagi; Evaluation of a completely automated tissue-sectioning machine for paraffin blocks; Journal of Clinical  Pathology doi:10.1136/jclinpath-2011-200205
  • Azadzoi K, Yalla S, Siroky M: “Human bladder smooth muscle cell damage in disturbed oxygen tension” has been published in the November issue of the Urology Journal 78:967-72, 2011
  • Azadzoi K, Chen B, Radisavljevic Z, Siroky M: “Molecular reactions and ultrastructural damage in the chronically ischemic bladder” has been published in the November issue of the Journal of Urology 186(5):2115-22, 2011

Publications: Accepted

  • Jiyoun Kim, Sudha Natarajan, Louis J. Vaickus, Jacqueline C. Bouchard, Dominic Beal, William W. Cruikshank, and Daniel G Remick; Title “Diesel Exhaust Particulates Exacerbate Asthma-like Inflammation by Increasing CXC ChemokinesManuscript,” has been accepted for publication and currently available online version of the American Journal of Pathology In addition, this article was selected by the editor for further in-depth discussion about our findings in the article in the journal’s “Commentary” section.

October 2011

October 3rd, 2011

Pathology & Laboratory Medicine News Items

Announcements:

  • Poster Presentations at CAP (College of American Pathology Meeting), September 2011
    • “Intrauterine Death in the Second and Third Trimester of Pregnancy Associated With Umbilical Cord Hypercoiling and Hypocoiling” Opoku Adjapong, MD; Sandra Cerda, MD; Carmen Sarita-Reyes, MD
    • “Expression Profiles of Cytokeratin and Epithelial Membrane Antigen in the Sarcomatous Element of Müllerian Tumors” (Poster No. 10) Hao Wu, MD, PhD; Carmen Sarita-Reyes, MD; Sandra Cerda, MD
  • Dr. Carmen Sarita-Reyes will be presenting “Placental Listeriosis and Acute Chorioamnionitis” accepted for the 2011 Society of Pediatric Pathology Fall Meeting Perinatal Slide Seminar  to be presented in Milwaukee, WI on September 30th 2011
  • Tiffany Mellott, PhD has received a grant from the Simons Foundation Autism Research Initiative (SFARI) for her research entitled; “Perinatal choline supplementation: a therapeutic approach to autism.” To date, the Simons Foundation¹s single largest initiative has been in autism research. The SFARI program seeks to improve the diagnosis and treatment of autism spectrum disorders by funding, catalyzing, and driving innovative research of the greatest quality and relevance.
  • We thought everybody should know that the Kurosawa Lab is making a NEWS in The Journal of Nature Medicine
  • The Martin Steffen Lab research project aimed at uncovering gene function had a focus story written about it in Microbe Magazine
  • Dr. Remick’s Lab had a new NIH grant funded R01 GM 97320, Adenosine and Oxygen Modulate Antimicrobial Defenses. This grant grew out of work by one of the former pathology graduate students, Bryan Belikoff. The grant was funded for 4 years and the work will be done in collaboration with Dr. Sitkovsky at Northeastern University
  • Dr. Ivana Delalle has been invited to chair a session on Translational Neurology at an international conference in Beijing, China in May next year
  • Missy Cohen MT (ASCP) MPH, our Human Tissue Coordinator, has a poster accepted for AABB (American Association of Blood Banks) annual meeting October 22-25 in San Diego.  Poster title is; “ISBT 128 and the Future of Tissue Traceability.” Missy collaborated with SC Sharpe, Northside Hospital, Atlanta, GA and C Rushing, Tampa General Hospital, Tampa FL
  • Nancy S. Miller, MD has been appointed to the Membership Committee of the American Society for Microbiology (ASM), 2011-2014
  • Zach Hunter’s, PhD candidate, abstract has been selected by the American Society of Hematology (ASH) Program Committee for presentation in an Oral Session at the 2011 Annual Meeting of the ASH in San Diego, California in December 2011. Abstract Title: “Whole-Genome Sequencing Results From 30 Patients with Waldenstrom’s Macroglobulinemia”

 

Abstracts Accepted:

  • Abstract Accepted for American Society of Clinical Pathologists (ASCP) Meeting in Las Vegas, Nevada, October 2011:  “Reducing Patient Waiting Times for Phlebotomy.” Stephen Hammond MD, Janet Means, Neil O’Neill, Michael Khang, Jason Ladmirault, and Martin Kroll MD (Nominated as a Finalist for Best Poster submitted by a Resident Award and Best Poster in Lab Practice Management Award)
  • Dr. Joel Henderson and the Renal Pathology Lab have several abstract posters accepted for presentation at the 2011 American Society of Nephrology Annual Meeting (“Kidney Week”) in Philadelphia November 8-13:
    • Actinins Suppress Podocyte Contractility Fangfang He, MD*1, Hui Chen, MD1, Philip A Bondzie, PhD1, Julie A. Tomolonis1, Daniel J. Becker, MD, PhD2, Martin R. Pollak, MD3 and Joel M. Henderson, MD, PhD1. 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States; 2Division of Nephrology, Brigham and Women’s Hospital, Boston, MA, United States and 3Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
    • Effect of Amyloidogenic Immunoglobulin Light Chains on the Contractile Cytoskeleton of Human Podocytes In Vitro Laura Econimo, MD*1, Julie A. Tomolonis1, Laura M. Dember, MD, FASN2, David C. Seldin, MD, PhD2, Lawreen H. Connors, PhD2 and Joel M. Henderson, MD, PhD1.
    • 1Pathology and Laboratory Medicine, Boston University Medical Center, Boston, MA, United States and 2Amyloid Treatment & Research Center, Boston University Medical Center, Boston, MA, United States.
    • Myosin  Expression  and  Kidney  Structure  in  Older  Heterozygous Myh9  Knockout  Mice Mostafa  BelghasemMD*1,  Joseph  S  Coppola1, Philip  A  Bondzie, PhD1Hui  Chen,  MD1,  Julie  A.  Tomolonis1 and  Joel  M. Henderson,   MD,  PhD1. 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States
  • Abstract accepted in NeuroTalk-2012 “Exosomal and Cell-Population miRNA Profiling in Brain Tissue of Patients Diagnosed with Bipolar Disorder;” Patricia F. Kao, Kozubek J, Banigan M, Vanderburg C, and Delalle I*

 

Publications: PUBLISHED

  • Athanasios Zovoilis, Hope Y Agbemenyah, Roberto C Agis-Balboa, Roman M Stilling, Dieter Edbauer,  Pooja Rao, Laurent Farinelli, Ivana Delalle, Andrea Schmitt,  Peter Falkai,  Sanaz Bahari-Javan, Susanne Burkhardt,  Farahnaz Sananbenesi &  Andre Fischer: “microRNA-34c is a novel target to treat dementias” The EMBO Journal doi:10.1038/emboj.2011.327
  • Gillespie, E., Leeman SE., Watts LA., Coukos J., O’Brien MJ., Cerda, JR., Farraye, FA., Stucchi, AF., Becker, JM. “The Truncated Neurokinin-1 receptor is Increased in Colonic Epithelial Cells from Patients with Colitis-Associated Cancer.”  Proceedings of the National Academy of Sciences (USA).  In Press, Published online as of October 3rd, 2011
  • Moitra R, Beal DR, Belikoff BG, Remick DG. “Presence of Pre-Existing Antibodies Mediate Survival in Sepsis.” Shock, September 2011, in press (PMID:21921828)

 

Publications: ACCEPTED

  • Tan, Josenia, Burke, Peter, Agarwal, Suresh, Mantilla-Rey, Nelson & Quillen, Karen: “A MASSIVE TRANSFUSION PROTOCOL INCORPORATING A HIGHER FFP: RBC RATIO IS ASSOCIATED WITH DECREASED USE OF RECOMBINANT ACTIVATED FACTOR VII IN TRAUMA PATIENTS” has been accepted for publication in the American Journal of Clinical Pathology

September 2011

September 15th, 2011

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Dr. Nader Rahimi has been awarded an Ignition Award from the Office of Technology of Boston University for development of humanized blocking monoclonal anti-IGPR-1 antibody for the treatment of human Lung Cancers. The provisional patent also has been filed for this novel technology.
  • Please give a warm welcome to our new students
    • Jessica Allen; PhD Candidate
    • Lujain Al-Sowaimel, MA Candidate
    • Laura Anthony, MA Candidate
    • Mostafa Belghasem, PhD Candidate
    • Chad Mayer, MD/PhD Candidate
    • Caitlin Miller; PhD Candidate
    • Timothy Norman, MA Candidate
    • John Veltre, MA Candidate
  • The summer has a flurry of activities going on with students interning from high schools and colleges in several pathology labs!
    • The Office of Summer Term’s program, Research Internship in Science and Engineering (RISE), once again offered rising high school seniors the opportunity to participate in basic science research for six weeks.  Forty-three students are places throughout the BU community and several were place in the Pathology and Immunology Departments:
      • Tim Elton in the Remick Lab hails from Detroit Country Day School, High School in Detroit, Michigan
      • Dave Sperber in the Remick Lab arrives from Bergin County Academies High School, Hackensack, New Jersey
      • Christopher Ng in the Kurosawa Lab comes from Monta Vista High in Cupertino, CA
      • Sharath Reddy was in the Cruikshank Lab, she is from Sacramento High School in California
    • These experiences culminated in a Poster Presentation on the Charles River Campus
PHOTO 1. RemickLabw-SummerStudents2011.Poster 08122011-14 Mentors Jackie Bouchard and Ritu Moitra, PhD Candidates with RISE Students, Dave Sperber and Tim Elton
PHOTO 2.Kurosawaw-SummerStudent2011.Poster 08122011-17 RISE Student Christopher Ng, Kurosawa Lab Members:  Caitlin Leibowitz, PhD Candidate and Danielle Day, Lab Technician

PHOTO 3.Dave Sperber PresentionPoster 08122011-5 Dave Sperber, RISE Student explaining his poster research

 

  • John Kim, PhD in the Remick Lab had junior Fay Feghali from Phillips Academy, who did a project entitled: “Optimization of bronchoalveolar lavage to minimize the variation of total cell numbers in a mouse model of asthma”
  • Dr. William Cruikshank also had Patrick Memari from Washington and Jefferson College, Washington, Pennsylvania. Patrick was here on a Howard Hughes Medical Institute Award granted through his college. Patrick’s project was entitled; “”Loss of Pro-IL-16 induces apoptotic resistance in T cells”
  • At the recent American Association for Clinical Chemistry (AACC) Annual Meeting , in Atlanta, Georgia (July 23-28th), Dr. Martin Kroll gave several presentations, including:
    • What Does It Take to Achieve Good Precision?  Enhancing Laboratory Operations Through Analytical Quality and Informatics
    • Biological Variation:  The Often Forgotten Source of Variation in Laboratory Test Results
    • Advantages and Challenges of the HIV Ag/Ab Combo Test
    • Dr. Kroll also presented at a roundtable on Laboratory Management
  • On behalf of Dr. Debbie Stearns-Kurosawa:  Please welcome Josh Brand to our Pathology Department.  Josh is a graduate of Tufts University (undergrad and Master’s program) and will be working as a full-time technician in the Kurosawa lab.  He’s a native of Miami, FL , teaches break dancing and has the good sense to be a fan of the Pittsburgh Steelers
  • Dr. Maria Panchenko, PhD was awarded a 5-year NIH grant; RO1 DK087910-01A1: “Histone Acetyl Transferase HBO1 in kidney epithelial cell cycle”

 

Abstracts Accepted:

  • Abstract accepted for publication in The EMBO Journal; MICRO-RNA-34C IS A NOVEL TARGET TO TREAT DEMENTIAS by Zovoilis , Agbemenyah, Agis-Balboa , Stilling , Rao , Edbauer , Farinelli , Delalle , Schmitt, Falkai , Bahari-Javan, Burkhardt , Sananbenesi and Fischer
  • Abstract accepted for poster presentation at the 48th Annual Meeting of the American Society of Dermatopathologists in Seattle, Washington; October 2011. “Expression of gelatinases (MMP-2, MMP-9) and gelatinase activator (MMP-14) in actinic keratosis and in in situ and invasive squamous cell carcinoma”  Marier Hernández-Pérez, MD; Mohamad El-hajahmad, MHCM; Meera Mahalingam, MD, PhD, FRCPath.
  • Abstract accepted to American Journal of Pathology “Diesel Exhaust Particulates Exacerbate Asthma-like Inflammation by Increasing CXC Chemokines” Jiyoun Kim, Sudha Natarajan, Louis J. Vaickus,  Jacqueline C. Bouchard, Dominic Beal, William W. Cruikshank, and Daniel G Remick

 

Publications: PUBLISHED

  • Resident Stephen Hammond, MD had a recent paper published: Daichi Hayashi, Stephen Hammond, Ali Guermazi; “Gastroenteropancreatic neuroendocrine tumors: multimodality imaging features with pathological correlation;” Japanese Journal of Radiology Mar 2011;29: 85-91
  • Recent publication from Kurosawa Lab:  Stearns-Kurosawa DJ, Collins V, Freeman S, Debord  D, Nishikawa K, Oh S-Y, Leibowitz CS, Kurosawa S.   Rescue From Lethal Shiga Toxin 2-induced Renal Failure with a Cell-Permeable Peptide.  Pediatric Nephrology, 2011, in press (PMID: 2160390)
  • Dr. Sandra Cerda has a paper published: Soucy G, Wang HH, Farraye FA, Schmidt JF, Farris AB, Lauwers GY, Cerda SR, Dendrinos KG, Odze RD. “Clinical and pathological analysis of colonic Crohn’s disease, including a subgroup with ulcerative colitis-like features,” Modern Pathology 2011 Aug 12. doi: 10.1038/modpathol.2011.120. [Epub ahead of print] Mod Pathol.

 

Publications ACCEPTED:

  • Sudha Natarajan, Jiyoun Kim, Jacqueline Bouchard, William Cruikshank, Daniel Remick. “Pulmonary Endotoxin Tolerance Protects against Cockroach Allergen-induced Asthma-like Inflammation in a Mouse Model.” Accepted for publication in International Archives of Allergy and Immunology
  • Michael H. A. Roehrl, Marier Hernandez, Shi Yang, Thomas G. Christensen, Claudio Morera, and Julia Y. Wang “Helicobacter Heilmannii Gastritis in a Young Patient with Pets” Gastrointestinal Endoscopy (2011, in press)
  • Azadzoi K, Chen B, Radisavljevic Z, and Siroky Mike: “Molecular Reactions and Ultrastructural Damage in the Chronically Ischemic Bladder” has been accepted for publication in the American Journal of Urology
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