News

June 2013

Published: July 11th, 2013

Pathology & Laboratory Medicine News Items

Announcements:

  • Castle Graduation Celebration 2013

miller

Dr. Nancy Miller with Graduate Dr. Yani Toribio, Dr. Grace Zhao and Graduate Dr. Joy Tan

sundugankamelmalek

First Years; Dr. Yue Sun, Dr. Cathryn Byrne-Dugan, Dr. Dhay Kamel and Dr. Anita Malek

pisteysemmel

Dr. Robert Pistey playing some soft music and resident Dr. Dana Semmel enjoying

 

  • Congratulations Graduating Resident, Dr. Josenia Tan who won the very first Robert Foley, MBA, Award. This honor will be given annually to a resident or fellow who “demonstrates the qualities that Mr. Foley brought to work every day.” This being the inaugural year of the prize Mr. Foley’s family was invited to the Castle Graduation Dinner.

    joyfoley

    Dr. Joy Tan receiving the first Annual Robert Foley, MBA, Award from Department Chair, Dr. Daniel Remick and Dr. Chris Andry cheering her on.

  • Congratulations on passing the Qualifying Exams!
    • Jessica Allen
    • Mostafa Belghasem
    • Melody Lun
    • Caitlin Miller
    • Jacquelyn Sikora
    • Jason Sutin
    • Thank you to all faculty members who assisted with the qualifying exams, with a SPECIAL Thank You Dr. Barbara Slack and the Qualifying Exam Committee
  • The Scientific Steering Committee of the XXIVth International Society on Thrombosis and Haemostasis (ISTH in Amsterdam, Netherlands; June 29-July 4) has determined that the abstract from the Kurosawa Lab “is likely to have an immediate and important impact on the practice of clinical medicine” and will be included in the ISTH publication with MD Conference Express which is a peer-reviewed meeting highlights report. This late-breaking abstract presented by Dr. Shinichiro Kurosawa is entitled:  “Complement is not activated in nonhuman primates during development of hemolytic uremic syndrome and thrombotic microangiopathy induced by E.coli Shiga toxins” by authors B.C. Lee, C.L. Mayer, C.S. Leibowitz, D.J. Stearns-Kurosawa, S. Kurosawa.
  • Dr. Ivana Delalle gave a platform presentation “Deregulation of Exosomal and Cellular microRNA in Bipolar Disorder,” American Association of Neuropathologists Meeting; Charleston, South Carolina  on June 22, 2013
  • Dominic Beal , PhD, successfully defended his thesis “Role of Macrophages in Cockroach Allergen Induced Asthma” on Tuesday, June 18th
  • The Hematology Lab (Renee Nutting, Daoreuang Pongvongkeo, and John Lee) has validated lupus anticoagulant testing on the in-house automated coagulation platform.  All lupus anticoagulant testing from now on will be performed in-house.
  • Dr. Carmen Sarita-Reyes was the guest lecturer of the “Dr. Manuel Felipe Pimentel Imbert Lecture” at her alma mater Universidad Nacional Pedro Henriquez Ureña School of Medicine on June 18th 2013 in Santo Domingo, Dominican Republic. The title of her lecture was “Pediatric Pathology Clinical and Surgical Management”.

Sarita.ReyesSpeakingatHerAlmaMater.Spring2013.DSC_0110 (2)

Sarita.Reyes.AlmaMaterwithPresentation.Spring2013.DSC_0149 (2)

 

  • Nick Woolf, MD/PhD student in Nader Rahimi’s laboratory has been awarded a full fellowship from the Center for Nanoscience and Nanobiotechnology,  Boston University for his project entitled “The Role of IGPR-1 in Tumor Growth and Progression”
  • Zachary Hunter, PhD candidate was an invited speaker at the 2013 International Waldenström’s Macroglobulinemia Foundation Educational Forum; “The Genomic Landscape of WM” May 17-19, San Diego, California
  • Zach Hunter also gave an oral presentation “Recurring Activating Mutations and Somatic Deletions Revealed Through Whole Genome Sequencing in WALDENSTRÖM’S MACROGLOBULINEMIA” at the12th International Conference on Malignant Lymphoma June 19-22, Lugano, Switzerland http://www.lymphcon.ch/
  • Dr. Carmen Sarita-Reyes gave a lecture on “Pediatric Pathology: Clinical-Pathologic Cases” at Robert Reid Cabral Children’s Hospital, Santo Domingo, Dominican Republic on June 25th 2013

Publications: ACCEPTED:

  • Liling Zeng, Ming Bai, Amit K. Mittal, Wassim El-Jouni, Jing Zhou, David M. Cohen, Mina I. Zhou, Herbert T. Cohen: Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal-cell carcinoma.  Cancer Research 2013 (in press)
  • Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Nader Rahimi. Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGFR-2. Accepted for publication in the Journal of Biological Chemistry

 

Publications: PUBLISHED:

  • Nicholas J. DeNunzio & Lija Joseph & Roxane Handal & Ankit Agarwal & Divya Ahuja & Ariel E. Hirsch. Devising the Optimal Preclinical Oncology Curriculum for Undergraduate Medical Students in the United States. J Canc Educ (2013) 28:228–236 DOI 10.1007/s13187-012-0442-0
  • Vipul Chitalia, Sowmya Shivanna, Jordi Martorell, Rosana Meyer, Elazer Edelman, and Nader Rahimi.  c-Cbl, a ubiquitin E3 ligase that targets active β-catenin – A novel layer of Wnt regulation Journal of Biol. Chem. jbc.M113.473801. First Published on June 6, 2013, doi:10.1074/jbc.M113.473801
  • Azadzoi KM and Siroky MB. Mechanism of lower urinary tract symptoms in pelvic ischemia. J Biochem & Pharmacol Res: 1: 64-74, 2013, 2013
  • Treon, S. P., & Hunter, Z. R. (2013). A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood, 121(22), 4434–4436. doi:10.1182/blood-2013-04-494849

May 2013

Published: June 7th, 2013

Pathology & Laboratory Medicine News Items –

Announcements:

  • 36th ANNUAL CONFERENCE ON SHOCK, June 1 – 4, 2013, San Diego, California:
    • PhD Candidates Evan Chiswick, Dominic Beal, and Surgical Resident/Researcher Juan Rodolfo Mella Remick Lab  will present a poster; “Too Zealous Too Soon: The Shift from Hyper to Hypo Reactive Phagocytes in Polymicrobial Sepsis”
    • Chad Mayer, MD/PhD candidate, Kurosawa Lab, has an abstract accepted for ORAL presentation at the 2013 Shock Society meetings in San Diego.  His abstract is entitled” DAMPs and endothelial dysfunction in a mouse model of Stx2 toxemia” by authors CL Mayer, CS Leibowitz, S Kurosawa, DJ Stearns-Kurosawa.
    • Caitlin Leibowitz, PhD candidate, Kurosawa Lab, has an abstract accepted for POSTER presentation at the 2013 Shock Society meeting in San Diego.  Her abstract is entitled “Neutropenia delays acute kidney injury in a murine Stx2 toxemia model” by authors C.S. Leibowitz, C.L. Mayer, S. Kurosawa, D.J. Stearns-Kurosawa.
    • Daniel Remick, M.D. was invited to give talk “Oxidante Regulation of Chemokine Gene Expression”
    • Daniel Remick, M.D. helped organize a panel discussion by all 5 level 1 trauma centers in the city of  Boston to discuss the trauma center’s experience with the Marathon Day bombings.
    • Daniel Remick, M.D., chaired the International Relations Committee and served as a member of council and Past-President of the Society.
    • Daniel Remick, M.D., organized the annual fun run, always a highlight of the meeting.
  • From the Remick Lab: PhD Candidate Evan Chiswick and Surgical Resident Juan Rodolfo Mella each received a Travel Award to attend next month’s SHOCK Conference in San Diego, California
  • David Stepien , MD/PhD, successfully defended his thesis “The Immune Response to Bacterial Pneumonia Following Traumatic Brain Injury” on Thursday, May 16th
  • MD/PhD Candidate Melody Lun has been awarded a grant from the American Federation for Aging Research (AFAR). The official title of the scholarship is “Glenn/AFAR Scholarship for Research in the Biology of Aging”
  • PhD Candidate Mostafa Belghasem received a fellowship (travel award) to attend the Intravital Microscopy Workshop at Indiana University Medical Center; this workshop was the week of May 5th
  • Barb Nikolajczyk, PhD was an invited to present at several events for May 2013:
    • Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes, 2013.
    • University of California at Los Angeles, Los Angeles, CA, Human B lymphocytes are master regulators of
    • American Association of Immunologists Annual Meeting, Honolulu, HI, Lymphocyte functions in type 2 diabetes, 2013.
    • University of Chicago, Department of Pathology. B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013.
  • A recent manuscript from the Kurosawa and Henderson labs, in collaboration with a group at Texas A&M was discussed in the May issue of the Kidney International Journal Club (Kidney International (2013) 83, 775–776. doi:10.1038/ki.2013.116).  This journal highlights the latest research from across a wide spectrum of journals in fields relevant to renal research.  The Kurosawa-Henderson manuscript identified differences in renal pathology elicited by toxins from enterohemorrhagic E.coli, a food and water-born pathogen, and supports the notion that therapeutic targeting of both bacterial toxins is of value.
  • Nancy S. Miller, MD lead a presentation and audience interactive session at the AACC Trimark Infectious Disease Conference on May 31, 2013 in Randolph, MA. “Point of Care Meets Microbiology:  What we have, what we need, what is on the way?  Preparing for the next frontier of point-of-care” In collaboration with Jean Ahern, C(ASCP) POC Specialist at BMC.
  • Dr. Carmen Sarita –Reyes has been appointed a member of the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee. Dr. Sarita-Reyes will be attending her first meeting from May 28th – 31st 2013 in Chicago, Illinois.
  • Dr. Kazem Azadzoi presented a moderated poster entitled “Sleep apnea causes bladder oxidative stress and nocturia in rats” at the American Urological Association (AUA) annual meeting in San Diego
  • Dr. Kazem Azadzoi also presented a moderated poster entitled “Upregulation of P2X purinergic receptors in bladder oxidative stress augments smooth muscle contractions” at the American Urological Association (AUA) annual meeting in San Diego

 

Publications: ACCEPTED:

  • Han-Pil Choi, Silvia Juarez, Sergio Ciordia, Marisol Fernandez, Rafael Bargiela, Juan P. Albar, Varun Mazumdar, Brian P. Anton, Simon Kasif, Manuel Ferrer, Martin Steffen. “Biochemical Characterization Of Hypothetical Proteins From Helicobacter pylori” PLoS One

In this paper, we present here the biochemical analysis of six proteins from Helicobacter pylori ATCC 26695. The functional characterization of Open Reading Frames (ORFs) from sequenced genomes remains a bottleneck in our effort to understand microbial biology. In particular, the functional characterization of proteins with only remote sequence homology to known proteins can be challenging, as there may be few clues to guide initial experiments. We provide a path towards this problem using affinity enrichment of proteins from cell lysates, and a global perspective of protein function as provided by COMBREX.

  • Resident Anita Deshpande, PGY-2, USCAP poster presentation held in Baltimore March 2013 on “Leiomyoma of the Gastrointestinal tract with Interstitial cells of Cajal: A mimic of gastrointestinal stromal tumor” has been accepted by American Journal of Surgical Pathology for publication.
  • Smith, B., S. Rozelle, J. Ubellacker, A. Parks, A. Leung, S. Nah, D. French, P. Gadue, S. Monti, D. Chui, M. Steinberg, D. Kotton, G. Mostoslavsky, D. Sherr, and G. Murphy. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood In Press
  • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology In Press
  • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. In Press
  • Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ*, Kurosawa S.* Quiescent complement in nonhuman primates during E.coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy.  Blood, 2013. (impact factor 9.8)

 

Publications: PUBLISHED:

  • Stearns-Kurosawa DJ, Oh S-Y, Cherla RP, Lee M-S, Tesh VL, Papin J, Henderson J, Kurosawa S.  Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic E.coli Shiga toxins in non-human primate models of hemolytic uremic syndrome.  American Journal of Pathology, 182(4):1227-38, 2013

April 2013

Published: May 1st, 2013

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Our own, Ryan Gould, Pathology Assistant, has been chosen to receive one of this year’s Boston Medical

    Ryan Gould being notified by the “Be Exceptional” Committee of his award

    Ryan Gould being notified by the “Be Exceptional” Committee of his award

    Center’s “Be Exceptional Awards!” Bravo Ryan! Ryan was notified of the award on April 24th along with an Edible Arrangements, balloons and an invitation to the May 8th “Be Exceptional Awards” Ceremony

  • The ASIP 2013 Annual Meeting at Experimental Biology; Boston, MA, April 20-24:
    • Dr. Daniel Remick organized a workshop for the American Society of Investigative Pathology at the 2013 Experimental Biology Meeting. The workshop was titled “We can’t all be PI’s: Preparing Graduate Students for Alternative Career Paths”. More than 700 attendees signed up for the workshop although there were actually only 80 attendees. Typically only 15 to 20 participants come to the workshop so there was significant interest in the topic. Additional information may be found at: http://www.asipcentennial.org//award_lectures/pls.cfm
    • Dr. Michael Greene, recent PhD, presented a poster entitled “”The circulating molecular chaperone clusterin interacts with amyloidogenic transthyretin oligomers and modulates amyloid formation”
    • PhD Candidate, Jacquelyn Sikora in Dr. Connors Lab, gave a poster, “Single nucleotide polymorphisms in the 3′ untranslated and near gene regions of transthyretin may play a role in senile systemic amyloidosis.” This poster is in the ASIP Translational Research in Human and Animal Models session, Monday April 22
    • Dr. Maria Panchenko and Post-doc Dr. Nirodhini Siriwardana presented the poster “Histone Acetyl Transferase (HAT) HBO1 and PHD Finger Protein 17 (PHF17/JADE1) in Epithelial Cell Regeneration” at “Experimental Biology”
  • Celebrating Lab Week!! April 22-26 is Medical Laboratory Professionals Week! It’s that time of year again; time to recognize and celebrate the dedication, hard work and excellence of our laboratory team! Click here for video

BMC Lab week

Linwood Beverly, Jean Hilaire

BMC Lab week 2

Janet Means, Neil O’Neill, Graziella Haddad, Diane Mullen

BMC Lab Week 3

Kevin Redmond of Abbott, Kathy Harkins, Charline Mack, Sarkis Chekijian of Abbott

  • Nancy S. Miller, MD presented the following at the New England Microbiology Medical Directors Meeting, April 24, 2013: “Developing a protocol for Fecal Microbiota Transplant: One institution’s story”
  • Dr. Karen Quillen was an invited speaker at the Massachusetts Association of Blood Banks Annual Spring Seminar in April. Title of talk was “Back to basics, and back to the future”

 

Publications: ACCEPTED:

  • Kendra N. Iskander, Marcin F. Osuchowski, Deborah J. Stearns-Kurosawa, Shinichiro Kurosawa, David Stepien, Catherine Valentine and Daniel G. Remick; Sepsis – Multiple Abnormalities, Heterogeneous Responses, Evolving Understanding; accepted April 29, 2013, Physiological Reviews.  This article was just accepted for publication in Physiological Reviews, which has an impact factor of 27. Physiological Reviews is ranked #5 among all biomedical scientific journals.

 

Publications: PUBLISHED:

  • Qu X, Li M, Liu HJ, Xiang Y, Tan Y, Weber HC, Qin XQ. Role of bombesin receptor activated protein in the antigen presentation by human bronchial epithelial cells. J Cell Biochem. 2013 Jan;114(1):238-44.
  • Weber HC. Medical treatment of neuroendocrine tumours. Curr Opin Endocrinol Diabetes Obes 2013;20:27-31.
  • Hermos JA, Altincatal A, H. Christian Weber, Grotzinger K, Smoot KJ, Cho K, Gagnon DR, Lawler EV. Thrombocytopenia and Bleeding in Veterans with Non-hepatitis C-related Chronic Liver Disease. Dig Dis Sci. 2013 Feb;58(2):562-73

March 2013

Published: April 3rd, 2013

Pathology & Laboratory Medicine News Items –

 

Announcements:

  • Read all about our very own Christian Kiriakos in the March installment of The BMC Brief;  “What Do You Do, Christian Kiriakos?” Link
  • Michael Greene, PhD, successfully defended his thesis “Evidence for a Role of the Molecular Chaperone Clusterin in Systemic Amyloidosis” on Monday March 25th
  • Heather Cohen Leach, PhD, successfully defended her thesis “Endothelial and Innate Immune Cross-Talk in the Pathogenesis of Pulmonary Fibrosis in Mice” on Wednesday, March 27th
  • Dr. Barbara Nikolajczyk has the following Invited Talks:
    • Miami 2013 Winter Symposium, The molecular basis of metabolism and nutrition, B lymphocytesare master regulators of a pro-inflammatory T cell balance in obesity and type 2 diabetes, Miami,Florida, 2013.
    • University of Miami, Department of Immunology, Miami FL, B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013
    • Children’s Hospital Los Angeles, Children’s Center for Cancer and Blood Diseases, Los Angeles,CA, Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2diabetes, 2013
    • 2nd Aegean Conference on Immunometabolism, Rhodes, Greece. B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013o
  • USCAP 2013; Baltimore, Maryland, March 2nd – 8th:
    • Joy Tan, MD, 4th year resident, et al presented a poster: “ANALYSIS OF BRAFV600EMUTATION IN PAPILLARY THYROID CARCINOMA WITH SINGLE OR MULTIPLETUMOR NODULES” Josenia Tan, Antonio de las Morenas, Shi Yang and Huihong Xuo

      Dr. Joy Tan, USCAP 2013

      Dr. Joy Tan, USCAP 2013

      Dr. Anita Deshpande, USCAP 2013

      Dr. Anita Deshpande, USCAP 2013

    • Anita Deshpande, MD 2nd year resident, et al presented a poster: “INTERSTITIAL CELLSOF CAJAL IN GASTROINTESTINAL LEIOMYOMA” Anita Deshpande, M.D, 2 VikramDeshpande, M.D, and 1Michael J O’Brien, M.Do

Publications ACCEPTED:

  • Tammy H. Osaki, Aaron Fay, Manisha Mehta, Nambi Nallasamy, Milton Waner, Dawn K. De Castro. Orbital development as a function of age in indigenous North American skeletons. Accepted forpublication by Ophthalmic Plastic and Reconstructive Surgery

 

Publications: PUBLISHED:

  • Iskander, Kendra; Craciun, Florin; Stepien, David; Duffy, Elizabeth; Kim, Jiyoun; Moitra,Rituparna; Vaickus, Louis; Osuchowski, Marcin; Remick, Daniel. Cecal ligation and puncture-induced murine sepsis does not cause lung injury. Critical Care Medicine 2013 Jan; 41 (1):159-70o
  • DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova,Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS,McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. B cells promote inflammation inobesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profileProceedings of the National Academy of Sciences (In Press)

February 2013

Published: March 1st, 2013

Announcements:

  • Dr. Barbara Nikolajczyk recently gave two talks:
    • At Miami 2013 Nature Winter Symposium on The Molecular Basis of Metabolism and Nutrition, “B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and type 2 diabetes”, on February, 13th 2013 in Miami, Florida
    • Also at the University of Miami, Department of Immunology, on February 14th 2013 also in Miami, “B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes”
  • Heather Cohen Leach, PhD Candidate has been invited to give an oral presentation at Experimental Biology 2013 on March 22nd in Boston entitled, “ENDOTHELIAL CELLS CONTRIBUTE TO INFLAMMATION AND FIBROSIS IN BLEOMYCIN INDUCED LUNG INJURY”
  • Dr. Nader Rahimi has been awarded OTD-HTS Ignition Award to develop a chemical inhibitor for renal cancer treatment

 

Publications ACCEPTED:

  • DeFuria, J, Belkina, AC, Jagannathan-Bogdan, M, Snyder-Cappione, J, Carr, JD, Nersesova, Y, Markham, D, Strissel, KJ, Watkins, A, Allen, J, Bouchard, J, Torald, G, Jasuja, R, Obin, MS, McDonnell, ME, Apovian, C, Denis, GV and Nikolajczyk, BS. “B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile” Accepted into PNAS (In Press)

 

Publications: PUBLISHED:

  • Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA. “Endothelial Cell-Specific Chemotaxis Receptor (ECSCR) enhances Vascular Endothelial Growth Factor (VEGF) Receptor-2/Kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.” Journal of Biological Chemistry, 2013 Feb 7

January 2013

Published: January 29th, 2013

Pathology & Laboratory Medicine News Items

Announcements:

  • Dr. Ivana Delalle gave an invited lecture on December 13th at the European Neuroscience Institute, Goettingen University in Germany. Title: “Deregulation of cortical exosomal miRNA expression in schizophrenia and bipolar disorder”
  • Missy Cohen in Laboratory Medicine spear-headed a proposal put together by our team of Tissue Coordinators and Tissue Coordinators from across the United States to present “The Role of the Blood Bank in Human Tissue Allograft and Distribution” at the AABB 2012 National Conference and the BMC proposal was accepted this week! It’s unclear at this point if Missy will be one of the presenters but we will keep you posted about a presentation!

 

Publications ACCEPTED:

  • Sebastien Malinge, Clarisse Thiollier, Timothy M Chlon, Louis C Dore, Lauren Diebold, Olivier Bluteau, Vinciane Mabialah, William Vainchenker, Phillipe Dessen, Susan Winandy, Thomas Mercher, and John Crispino. “Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling” Accepted for publication in Blood
  • Susan Winandy, PhD. “Ikaros to the rescue of TCRα chain gene rearrangement “by Susan Winandy.  Invited commentary to appear in the European Journal of Immunology
  • Belkina, AC, Nikolajczyk, BS, Denis, GV. 2013. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. Journal of  Immunology (In Press)
  • Authors Banigan MG*, Kao PF* (*equal contribution), Kozubek JA, Winslow AR, Medina J, Costa J, Schmitt A, Schneider A, Cabral H, Cagsal-Getkin O, Vanderburg CR, and Delalle I. “Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients”  Scheduled to be published in PLOS ONE on January 30, 2013

 

Publications: PUBLISHED:

  • JN Ollivierre, JL Sikora, PJ Beuning. Dimer exchange and cleavage specificity of the DNA damage response protein UmuD. Biochimica et Biophysica Acta 2013 Feb. 1834(2) 611-620
  • Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X, Morra E, Trojani A, Greco A, Arcaini L, Varettoni M, Brown JR, Tai YT, Anderson KC, Munshi NC, Patterson CJ, Manning R, Tripsas C,Lindeman NI, Treon SP. MYD88 L265P in Waldenstrom’s Macroglobulinemia, IgM Monoclonal Gammopathy, and other B-cell Lymphoproliferative Disorders using Conventional and Quantitative Allele-Specific PCR. Blood. 2013 Jan 15. [Epub ahead of print]

December 2012

Published: January 8th, 2013

Pathology & Laboratory Medicine News Items

Announcements:

  • Once again our very own, Dr. Antonio de las Morenas, made Boston Magazine’s “Top Doctors 2012” List. Bravo Dr. de las Morenas!!!
  • The Department of Pathology & Laboratory Medicine Blood Bank and Transfusion Service just received formal accreditation by AABB, following our inspection of Nov 8 and 9, 2012. Our quality and operational system were assessed and determined to meet or exceed the rigorous requirements set by the association. Kate Murphy reports that we were recommended for a “commendable practice” for our process of ABO/Rh confirmation of all new to BMC patients.
  • PhD Candidate Zachary Hunter presented a poster at the American Society of Hematology on December  9th in Atlanta: “Whole Genome Sequencing Identifies Recurring Somatic Mutations in the C-Terminal Domain of CXCR4, Including a Gain of Function Mutation in Waldenstrom’s Macroglobinemia” Yang Cao, Lian Xu, Xia Liu, Yangsheng Zhou, Guang Yang, Christopher J Patterson, Steven Peter Treon, and Zachary Hunter
  • Elizabeth Stanford, a predoctoral candidate in the laboratory of Dr. David Sherr (BU Immunology Training

    Liz Stanford wins Art Because Seed-the-Scientist

    Liz Stanford wins Art Because Seed-the-Scientist

    Program Director and BU Superfund Research Program Deputy Director), was recently honored with a $60,000 Seed-The-Scientist Award from the Art beCAUSE Breast Cancer Foundation. Ms. Stanford’s work on the role of the aryl hydrocarbon receptor and its environmental ligands on breast cancer stem cell development and propagation is based on studies on the AhR  supported by the Superfund Research Program. The award was made at the annual Art beCAUSE fund-raiser gala, at which Ms. Stanford was the keynote speaker.

  • Dr. David Sherr was recently awarded two translational grants. Earlier studies from the Sherr laboratory demonstrated the role of the AhR in controlling normal and malignant cell function. Here, grants from the Mary Kay Foundation and from the Wallace B. Coulter Foundation were awarded to Dr. Sherr’s laboratory to translate these studies into clinical practice by developing AhR modulators capable of blocking AhR-dependent triple negative breast cancer cell growth and metastasis.
  • Dr. David Sherr was recently interviewed by Susan Warnick of the Boston TV station WCVB on his work evaluating the effects of environmental chemicals on the development and progression of breast cancer. Click Here for video.

 

Publications ACCEPTED:

  • Iskander, Kendra; Craciun, Florin; Stepien, David; Duffy, Elizabeth; Kim, Jiyoun; Moitra, Rituparna; Vaickus, Louis; Osuchowski, Marcin; Remick, Daniel.  Cecal Ligation and Puncture-Induced Murine Sepsis Does Not Cause Lung Injury.  Critical Care Medicine
  • Stearns-Kurosawa DJ, Oh S-Y, Cherla RP, Lee M-S, Tesh VL, Papin J, Henderson J, Kurosawa S.  Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic E.coli Shiga Toxins in Non-human Primate Models of Hemolytic Uremic Syndrome.  American Journal of Pathology, 2013 in press.

 

Publications: PUBLISHED:

  • Flanigon J, Kamali-Moghaddam M, Burbulis I, Annink C, Steffen M, Oeth P, Brent R, van den Boom D, Landegren U, Cantor C. Multiplex Protein Detection with DNA Readout via Mass Spectrometry. N Biotechnol. 2012 Nov 28. pii: S1871-6784(12)00860-6. doi: 10.1016/j.nbt.2012.11.003. [Epub ahead of print]
  • Treon SP, Xu L, Hunter ZR. MYD88 L265P Somatic Mutation in IgM MGUS. New England Journal of Medicine 2012 Dec 6;367(23):2255-6

November 2012

Published: December 4th, 2012

Pathology & Laboratory Medicine News Items

 

Announcements:

  • Dr. Antonio de las Morenas gave the annual Stanley L. Robbins lecture to the New England Society of Pathologists on November 13th. This lecture is named in honor of Dr. Robbins, former Chair of Pathology and Laboratory Medicine at Boston University School of Medicine. Dr. de las Morenas’s  lecture “Challenges in the Diagnosis of Well Differentiated Thyroid Carcinoma” was presented to a standing room only group of pathologists.
  • Kurosawa Lab News:
    • An invited review was published from the Kurosawa Lab in Toxins, in a special issue entitled: Novel Properties of Well-Characterized Toxins.  First authorship is shared by Pathology graduate students Chad Mayer (MD,PhD candidate) and Caitlin Leibowitz (PhD candidate), who wrote most of the text and contributed equally.
  • Mayer, CL*, Leibowitz, CS*, Kurosawa S, Stearns-Kurosawa, DJ. Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals.  Toxins4(11), 1261-1287, 2012.  doi:10.3390/toxins4111261.  *Equal first authors
  • Dr. Stearns-Kurosawa was invited to give a presentation at the American Society of Nephrology in San Diego, October 30 – November 4, in a session dedicated to new treatments for atypical hemolytic uremic syndrome and Shiga toxin-related acute kidney injury.  Her presentation was entitled “Development and Treatment of HUS in Nonhuman Primates Induced by Toxins from Enterohemorrhagic E.coli.
  • Dr. Forum Raval has joined Barbara Nikolajczyk’s lab as a post-doctoral fellow. Forum did her PhD in Immunology with Dr. Eva Szomolanyi-Tsuda at UMass Medical School. She is joining BU as a recipient of a Hematology Training Program Award
  • Dr. Daniel Remick served on a panel of speakers at the 2012 Society of Leukocyte Biology workshop on grantsmanship October 28 – 30 in Maui, Hawaii
  • Dr. Carmen Sarita-Reyes was part of a panel that discussed “The use of AJCC Staging in Clinical Practice, Including the use of prognostic indicators, evidence based national guidelines used in treatment planning in breast cancer cases”. Presenters: Dr. Carmen D. Sarita-Reyes, Dr. Jane Mendez, and Dr. Moussa Sissoko. November 21st 2012, 670 Albany Street; Lobby Level #107/108.

 

Publications ACCEPTED:

  • Bouchard, Jacqueline; Beal, Dominic; Kim, Jiyoun; Vaickus, Louis; Remick, Daniel. CHEMOKINES MEDIATE ETHANOL-INDUCED EXACERBATIONS OF MURINE COCKROACH ALLERGEN ASTHMA Authors: To be published in Clinical and Experimental Immunology

 

Publications: PUBLISHED:

  • Wood DE, Lin H, Levy-Moonshine A, Swaminathan R, Chang YC, Anton BP, Osmani L, Steffen M, Kasif S, Salzberg SL. Thousands of missed genes found in bacterial genomes and their analysis with COMBREX Biology Direct. 2012 Oct 30;7(1):37

October 2012

Published: November 15th, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • The Cancer Human Biobank Project at the NCI has funded a two year contract with the Department of Pathology and Laboratory Medicine at BMC worth up to $500,000-.  The collection of biospecimens in a pre-analytic variables study will bring the biospecimen archive research core (BARC) to the next level in state-of-the-art biospecimen collection, preservation and analysis.  This award is a culmination of departmental and hospital-wide investment in preparation for this project
  • Barbara Nikolajczyk, PhD has been invited to present her team’s work on “Immunometabolism” at
    • The Miami 2013 Winter Symposium: The Molecular Basis of Metabolism and Nutrition in February, 2013 as well as the following presentations:
    • American Association of Immunologists, Guest Symposium speaker, “B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance”, Honolulu Hawaii, 2013
    • University of Miami, Department of Immunology, Miami Florida, “Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes”, 2013
    • Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, “Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes,” 2013
  • 2nd Year Resident Manisha Mehta’s poster has been accepted by the AAOOP (American Association of Ophthalmic Oncologists and Pathologists) for their 2012 Annual meeting to be held in Chicago on Nov 9, 2012. “Immunological profile of 2 cases of conjunctival SCC from Africa”; Manisha Mehta, Stephen Christiansen, Jose Caro, Nora Laver
  • Congratulations to Dr. Huihong Xu as the Shattuck Hospital’s New Chief of Pathology
  • Jason Sutin, PhD student presented the poster “Simultaneous Optical and Electrical Measurement of Neurovascular Coupling in Awake Rats” at Neuroscience 2012 on October 17th in New Orleans
  • Dr. Sandra Cerda received a Poster Citation for her poster presented October 21st at the ACG (American College of Gastroenterology) 2012 Annual Scientific Meeting in Las Vegas, Nevada; “Significance of granulomatous inflammation found on endoscopic biopsies or surgical resections on the severity and prognosis of Crohn’s Disease.” Kanneganti M, Dehghani B, Steinberg J, Cerda S, Rybin D, Weinberg J, Farraye FA.
  • PhD Student Zach Hunter’s abstract was selected for an oral presentation at the BU Genomic Science Institute symposium this past Monday (10/22). “Copy Number and Small Variant Analysis from Whole Genome Sequencing of 30 Patients with Waldenstrom’s Macroglobulinemia” Link to the BU GSI website
Pumpkin2 Bravo, Spooktacular to Lab Medicine for being one of the tip three Pumpkin Decorating Contest winners with “The Mad Scientist” pumpkin! Pumpkin1

 

Publications: PUBLISHED:

  • Snyder-Cappione, JE and Nikolajczyk, BS. When Diet and Exercise Aren’t Enough, Think Immunomodulation. 2012. Molecular Aspects of Medicine. (In Press).
  • Kanneganti M, Dehghani B, Steinberg J, Cerda S, Rybin D, Weinberg J, Farraye FA. Significance of granulomatous inflammation found on endoscopic biopsies or surgical resections on the severity and prognosis of Crohn’s Disease.  American  Journal of Gastroenterology 2012;107:S633
  • Treon, S. P., Tripsas, C., Hanzis, C., Ioakimidis, L., Patterson, C. J., Manning, R. J., Sheehy, P., Turnbull B, Hunter ZR. Familial Disease Predisposition Impacts Treatment Outcome in Patients With Waldenström Macroglobulinemia. Clinical lymphoma, myeloma & leukemia. doi:10.1016/j.clml.2012.08.006

September 2012

Published: October 9th, 2012

Pathology & Laboratory Medicine News Items

Announcements:

  • Zachary Hunter, PhD Candidate, spoke at the 7th International Workshop on Waldenstrom’s Macroglobulinemia in Newport, Rhode Island, August 23-26, 2012 this included:
    • Mutational Landscape of WM  Revealed  Through Whole Genome Sequencing
    • MYD88 L265P as a response marker in  Waldenstrom’s Macroglobulinemia
  • Zach followed up his presentation with in a workshop summary session for patients following: Revelation of MYD88 L265P as a Novel Mutation in WM
  • Barbara Nikolajczyk, PhD has been awarded a new grant; “The Role of Lymphocytes in Diet-Induced Metabolic Disease,” NIH/NIDDK R56, Funding Period – 9/1/12 – 8/31/13
  • Barbara Nikolajczyk, PhD made presentations at:
    • The Obesity Society Pre-conference Workshop on Adipocyte Metabolism “Lymphocytes in Immunometabolism” San Antonio, Texas, September 20-21, 2012
    • The Obesity Society Plenary Oral Presentation, B lymphocytes are master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance, San Antonio, Texas, September 20-21, 2012
  • The Nikolajczyk Lab has a new addition: Anna Blekina has joined the lab as a post-doctoral fellow
  • Missy Cohen in Laboratory Medicine was a presenter on a panel at the American Association of Tissue Banks (AATB). She discussed our method of storing and managing tissue through Transfusion Services in a similar manner as managing blood as opposed to managing and storing tissues in the O.R. The purpose of the panel as a whole was to convince tissue procurement and processing groups of using an international method of labeling tissue known as ISBT128 labeling. This method of labeling has been a requirement of the AABB (American Association of Blood Banks) for several years now with great success of being able to uniquely identify every unit of blood that has been collected on an international level and allowing for improved distribution of blood across borders which, in turn, allows blood to be delivered to places that need it most.
  • Next month Missy Cohen will be visiting with the Vice President of Tissue Services at the New England Organ Banks (NEOB), Diana Buck, to tour their facility and see where the tissues and organs that we use come from. While there, Missy will be sharing information with Diana and her staff about ISBT128 labeling and how their tissue improves the lives of our patients
  • Dr. Lija Joseph presented:
    • A poster at the College of American Pathologists Annual Meeting, San Diego California, September 9-12, 2012; “Optimizing Hematopathology Services in a Community Hospital Setting” (Poster No. 51) Joseph L; Ibrahim, S; Anamur M,  Gryzenia, P , 2012) Abstracts and Case Studies From the College of American Pathologists 2012 Annual Meeting (CAP ’12). Archives of Pathology & Laboratory Medicine: September 2012, Vol. 136, No. 9, pp. 1005-1162
    • A second poster presented at the College of American Pathologists Annual Meeting, San Diego California, September 9-12, 2012. “Unusual Findings in a Knee Joint Treated With Hyaluronidase and Steroids” (Poster No. 70) Joseph L, Wu, H 2012) Abstracts and Case Studies From the College of American Pathologists 2012 Annual Meeting (CAP ’12). Archives of Pathology & Laboratory Medicine: September 2012, Vol. 136, No. 9, pp. 1005-1162.
  • Dr. Ivana Delalle will represent the Department of Pathology on a regular basis at a recently started conference series “Clinical Neuroscience Grand Rounds”

 

Publications Accepted:

  • Sudha Natarajan, Daniel G. Remick. ELISA Rescue Protocol: Recovery of Sample Concentrations from an Assay with an Unsuccessful Standard Curve. Methods
  • Andrea Havasi, Joseph A. Haegele, Jonathan M. Gall, Sherry Blackmon, Takaharu Ichimura, Ramon G. Bonegio, Maria V. Panchenko.  Histone Acetyl Transferase (HAT) HBO1 and JADE1 in Epithelial Cell Regeneration” Accepted for publication in the American Journal of Pathology
  • Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek K, Germino GG, Zhou MI, Cohen HT: Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Human Molecular Genetics 2012 (in press)
  • Earl Gillespie a, Susan E. Leeman a, Luisa A. Watts d, Jennifer A. Coukos c, Michael J. O’Brien d, Sandra R. Cerda d, Francis A. Farraye c, Arthur F. Stucchi b. Plasminogen Activator Inhibitor-1 is Increased in Colonic Epithelial Cells from Patients with Colitis-Associated Cancer☆. Journal of Crohn’s and Colitis
  • Tolga Sursal1*, Deborah J Stearns-Kurosawa2*, Kiyoshi Itagaki1, Sun-Young Oh2**, Shiqin Sun1**, Shinichiro Kurosawa2, Carl J Hauser1.  Plasma Bacterial and Mitochondrial DNA Distinguish Bacterial Sepsis from Sterile SIRS and Quantify Inflammatory Tissue Injury in Nonhuman Primates. SHOCK in press

 

Publications: PUBLISHED

  • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D., Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., ason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary R. Hunter, M.A. MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia. The New England Journal of Medicine, med 367;9 nejm.826 org august 30, 2012
  • Joseph L (Chapter 2, pages 31-44) Non-neoplastic disorders of platelets: in Nonneoplastic hematopathology and infections, Editors Cualing, Bhargava ans Sandin; Wiley-Blackwell 2012.