Wellington V. Cardoso MD, PhD
Adjunct Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
72 E. Concord Street | (617) 638-6198wcardoso@bu.edu
Sections
Pulmonary, Allergy, Sleep & Critical Care Medicine
Biography
My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
Other Positions
Education
MD, Universidade de Brasília
PhD, Universidade de São Paulo
Publications
Otoshi T, Kotton BD, Kameshwar AK, Seki Y, Cardell Z, Ke X, Matsuno Y, Rajaram P, Kim YK, Sharpton SM, Quadro L, Cardoso WV, Suzuki M. Genetic background influences developmental airway smooth muscle program and susceptibility to airway hyperresponsiveness in mice. JCI Insight. 2026 Jul 21. PMID: 42479456.
Published on 4/21/2026Ke X, Cardoso WV. Transitional cell states at the crossroads of development, disease, and repair-regeneration. Physiol Rev. 2026 Jul 01; 106(3):2059-2078. PMID: 42012134.
Published on 11/3/2025Otoshi T, Kameshwar AKS, Kotton BD, Seki Y, Cardell Z, Xiangyi K, Matsuno Y, Rajaram P, Kim YK, Sharpton SM, Quadro L, Cardoso WV, Suzuki M. Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice. bioRxiv. 2025 Nov 03. PMID: 41279414.
Published on 9/5/2025Ke X, van Soldt B, Vlahos L, Zhou Y, Qian J, Laise P, George J, Capdevila C, Glass I, Yan K, Califano A, Cardoso WV. Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. Dev Cell. 2025 Sep 22; 60(18):2533. PMID: 40914171.
Published on 5/16/2025Dirvin B, Noh H, Tomassoni L, Cao D, Zhou Y, Ke X, Qian J, Jangra S, Schotsaert M, García-Sastre A, Karan C, Califano A, Cardoso WV. Identification and targeting of regulators of SARS-CoV-2-host interactions in the airway epithelium. Sci Adv. 2025 May 16; 11(20):eadu2079. PMID: 40378209.
Published on 2/1/2025Makrides N, Sun E, Mir H, Jiang Z, Wu Y, Serra C, Cardoso WV, Shah NH, Zhang X. Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2. bioRxiv. 2025 Feb 01. PMID: 39974929.
Published on 12/11/2024Ke X, van Soldt B, Vlahos L, Zhou Y, Qian J, George J, Capdevila C, Glass I, Yan K, Califano A, Cardoso WV. Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. Dev Cell. 2025 Mar 24; 60(6):819-836.e7. PMID: 39667932.
Published on 10/14/2024Dirvin B, Noh H, Tomassoni L, Cao D, Zhou Y, Ke X, Qian J, Schotsaert M, García-Sastre A, Karan C, Califano A, Cardoso WV. Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium. bioRxiv. 2024 Oct 14. PMID: 39464067.
Published on 7/15/2024Mori M, Cardoso WV. Can a Rat Breathe through a Mouse's Lung? Am J Respir Crit Care Med. 2024 Jul 15; 210(2):133-134. PMID: 38701370.
Published on 7/1/2024Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335.