Shinobu Matsuura DVM, PhD
Assistant Professor, Cardiovascular Medicine
700 Albany St | (617) 358-8245shinobu@bu.edu
Sections
Cardiovascular Medicine
Centers
BU-BMC Cancer Center
Whitaker Cardiovascular Institute
Evans Center for Interdisciplinary Biomedical Research
Biography
My major research focus is hematopoietic stem cell (HSC) biology and processes that lead to its de-regulation in malignancy. My knowledge and expertise in veterinary medicine allows me to most effectively use animal models for research that have significant translational potential. My current project focus is myeloproliferative neoplasm stem cells driven by the JAK2V617F mutation. We perform in-depth phenotyping of HSC using analytical flow cytometry, transcriptomics, in vivo functional studies using bone marrow transplantation, and in vitro studies of primary HSCs. Through those studies, we aim to uncover the HSC defects that characterize this pre-malignant disease, and understand the process of transformation from normal to the malignant state.
Education
Life Sciences/Agriculture, PhD, University of Tokyo
Veterinary Science, DVM, Universidade de São Paulo
Publications
Karagianni A, Karkempetzaki AI, Brooks D, Matsuura S, Dambal V, Trackman PC, Ravid K. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. Blood. 2024 Jun 20; 143(25):2666-2670. PMID: 38635757.
Published on 6/10/2024Arimoto KI, Zhang Y, Matsuura S, Miyauchi S, Zhang DE. Hypersensitivity to type I interferon as a cause of hydrocephalus development. Brain Res. 2024 Oct 01; 1840:149082. PMID: 38866307.
Published on 1/2/2024Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349. PMID: 38165047.
Published on 7/8/2022Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498. PMID: 35880162.
Published on 12/21/2021Matsuura S, Balduini A, Onisto M. Editorial: Mechanisms of Cell Adhesion in Hematopoietic Stem Cells. Front Cell Dev Biol. 2021; 9:826554. PMID: 34993206.
Published on 12/12/2021Yang X, Chitalia SV, Matsuura S, Ravid K. Integrins and their role in megakaryocyte development and function. Exp Hematol. 2022 02; 106:31-39. PMID: 34910941.
Published on 9/15/2021Lim KH, Matsuura S, Xu B. Editorial: Novel Treatment Strategies for Myeloproliferative Neoplasms. Front Oncol. 2021; 11:762928. PMID: 34604100.
Published on 8/20/2020Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272. PMID: 32814440.
Published on 6/18/2020Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291. PMID: 32294178.
Published on 10/21/2019Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. Int J Hematol. 2019 Dec; 110(6):699-708. PMID: 31637674.