Richard M. Sherva PhD

Assistant Professor, Biomedical Genetics

Member, Genome Science Institute

72 E. Concord Street | (617) 638-5361
Richard Sherva
Sections

Biomedical Genetics

Centers

Evans Center for Interdisciplinary Biomedical Research

Biography

My primary interest is in exploring the genetic epidemiology of complex disease using linkage and association methods. I’ve worked on cardiovascular phenotypes including hypertension, metabolic syndrome, and stroke, as well as psychiatric diseases including addiction and ADHD, with a focus on gene x (gene, environment, drug treatment) interactions. My future work will likely involve pharmacogenetics and personalized medicine, with specific focus on Alzheimer’s disease.

Other Positions

Education

Epidemiology, PhD, University of Minnesota

Epidemiology, MPH, University of Minnesota

Biology, BA, Gustavus Adolphus College

Publications

Published on 3/14/2025

Pierce ME, Logue M, Sherva R, Miller M, Huber BR, Milberg W, Hayes JP. Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-ß42:40 in Veterans. J Alzheimers Dis. 2025 Mar 14; 13872877251321183. PMID: 40084666.

Published on 2/13/2025

Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez J, Farrer LA. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. medRxiv. 2025 Feb 13. PMID: 39990565.

Published on 12/18/2024

Merritt VC, Zhang R, Sherva R, Ly MT, Marra D, Panizzon MS, Tsuang DW, Hauger RL, Logue MW. Curation and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program. J Alzheimers Dis. 2025 Jan; 103(1):180-193. PMID: 39692476.

Published on 10/1/2024

Belloy ME, Le Guen Y, Stewart I, Williams K, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. Role of the X Chromosome in Alzheimer Disease Genetics. JAMA Neurol. 2024 Oct 01; 81(10):1032-1042. PMID: 39250132.

Published on 10/1/2024

Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002. PMID: 38959008.

Published on 6/29/2024

Neale ZE, Fonda JR, Miller MW, Wolf EJ, Zhang R, Sherva R, Harrington KM, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue MW. Subjective cognitive concerns, APOE e4, PTSD symptoms, and risk for dementia among older veterans. Alzheimers Res Ther. 2024 Jun 29; 16(1):143. PMID: 38951900.

Published on 4/23/2024

Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. The Role of X Chromosome in Alzheimer's Disease Genetics. medRxiv. 2024 Apr 23. PMID: 38712163.

Published on 4/4/2024

Wolf EJ, Miller MW, Zhang R, Sherva R, Harrington KM, Fonda JR, Daskalakis NP, Gaziano JM, Logue MW. No Replication of Alzheimer's Disease Genetics as a Moderator of Combat Exposure's Association with PTSD risk in 138,592 Combat Veterans. Nat Ment Health. 2024 Apr 04; 2:553-561. PMID: 39247144.

Published on 12/1/2023

Zheng Y, Lunetta KL, Liu C, Smith AK, Sherva R, Miller MW, Logue MW. A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data. Epigenetics. 2023 Dec; 18(1):2207959. PMID: 37196182.

Published on 11/21/2023

Shwani T, Zhang C, Owen LA, Shakoor A, Vitale AT, Lillvis JH, Barr JL, Cromwell P, Finley R, Husami N, Au E, Zavala RA, Graves EC, Zhang SX, Farkas MH, Ammar DA, Allison KM, Tawfik A, Sherva RM, Li M, Stambolian D, Kim IK, Farrer LA, DeAngelis MM. Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration. Cells. 2023 Nov 21; 12(23). PMID: 38067097.

View full list of 86 publications.