Richard M. Sherva PhD
Assistant Professor, Biomedical Genetics
Member, Genome Science Institute
72 E. Concord Street | (617) 638-5361sherva@bu.edu
Sections
Biomedical Genetics
Centers
Evans Center for Interdisciplinary Biomedical Research
Biography
My primary interest is in exploring the genetic epidemiology of complex disease using linkage and association methods. I’ve worked on cardiovascular phenotypes including hypertension, metabolic syndrome, and stroke, as well as psychiatric diseases including addiction and ADHD, with a focus on gene x (gene, environment, drug treatment) interactions. My future work will likely involve pharmacogenetics and personalized medicine, with specific focus on Alzheimer’s disease.
Other Positions
Education
Epidemiology, PhD, University of Minnesota
Epidemiology, MPH, University of Minnesota
Biology, BA, Gustavus Adolphus College
Publications
Han X, Zhang Y, Petrosky JN, Bald S, Sherva RM, Labadorf A, Cherry JD, Chung J, Farrell K, Abdolmohammadi B, Durape S, Martin BM, Palmisano JN, Farrell JJ, Alvarez VE, Huber BR, Dwyer B, Daneshvar DH, Dams-O'Connor K, Jun GR, Lunetta KL, Goldstein LE, Katz DI, Cantu RC, Shenton ME, Cummings JL, Reiman EM, Stern RA, Alosco ML, Tripodis Y, Farrer LA, Stein TD, Crary JF, McKee AC, Mez J. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell Rep Med. 2025 Apr 09; 102084. PMID: 40239644.
Published on 3/14/2025Pierce ME, Logue M, Sherva R, Miller M, Huber BR, Milberg W, Hayes JP. Association of Alzheimer's disease genetic risk with age-dependent changes in plasma amyloid-ß42:40 in Veterans. J Alzheimers Dis. 2025 Apr; 104(4):1006-1012. PMID: 40084666.
Published on 2/13/2025Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez J, Farrer LA. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. medRxiv. 2025 Feb 13. PMID: 39990565.
Published on 12/18/2024Merritt VC, Zhang R, Sherva R, Ly MT, Marra D, Panizzon MS, Tsuang DW, Hauger RL, Logue MW. Curation and validation of electronic medical record-based dementia diagnoses in the VA Million Veteran Program. J Alzheimers Dis. 2025 Jan; 103(1):180-193. PMID: 39692476.
Published on 10/1/2024Belloy ME, Le Guen Y, Stewart I, Williams K, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. Role of the X Chromosome in Alzheimer Disease Genetics. JAMA Neurol. 2024 Oct 01; 81(10):1032-1042. PMID: 39250132.
Published on 10/1/2024Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002. PMID: 38959008.
Published on 6/29/2024Neale ZE, Fonda JR, Miller MW, Wolf EJ, Zhang R, Sherva R, Harrington KM, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue MW. Subjective cognitive concerns, APOE e4, PTSD symptoms, and risk for dementia among older veterans. Alzheimers Res Ther. 2024 Jun 29; 16(1):143. PMID: 38951900.
Published on 4/23/2024Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. The Role of X Chromosome in Alzheimer's Disease Genetics. medRxiv. 2024 Apr 23. PMID: 38712163.
Published on 4/4/2024Wolf EJ, Miller MW, Zhang R, Sherva R, Harrington KM, Fonda JR, Daskalakis NP, Gaziano JM, Logue MW. No Replication of Alzheimer's Disease Genetics as a Moderator of Combat Exposure's Association with PTSD risk in 138,592 Combat Veterans. Nat Ment Health. 2024 Apr 04; 2:553-561. PMID: 39247144.
Published on 12/1/2023Zheng Y, Lunetta KL, Liu C, Smith AK, Sherva R, Miller MW, Logue MW. A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data. Epigenetics. 2023 Dec; 18(1):2207959. PMID: 37196182.