Kostas Alysandratos MD, PHD
Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
670 Albany St | (617) 414-2969kalysa@bu.edu
konstantinos.alysandratos@bmc.org
Sections
Pulmonary, Allergy, Sleep & Critical Care Medicine
Centers
Center for Regenerative Medicine
Pulmonary Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Konstantinos Alysandratos, MD, PhD is an Assistant Professor in the Pulmonary, Allergy, Sleep & Critical Care Medicine Section at Boston University Chobanian & Avedisian School of Medicine and serves as Co-Director of the Interstitial Lung Disease (ILD) Clinic at Boston Medical Center, where he specializes in the treatment of complex lung diseases. He is also a Principal Investigator at the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, leading an NIH-funded research program aimed at advancing the understanding of pulmonary fibrosis pathogenesis and identifying druggable targets, particularly within the alveolar epithelium, using pluripotent stem cell model systems. Dr. Alysandratos earned his MD and PhD degrees from the University of Athens in Greece, completed his internal medicine residency at the University of Texas Southwestern Medical Center, and completed fellowships in Sleep Medicine and Pulmonary/Critical Care Medicine at Boston University.
Education
Medicine, MD, University of Athens
Immunology/Pharmacology, PhD, University of Athens
Publications
Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight. 2025 Aug 08; 10(15). PMID: 40591409.
Published on 6/12/2025Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122. PMID: 40504150.
Published on 3/5/2025Burgess CL, Ayers LJ, Minakin K, Alysandratos KD, Varelas X, Kotton DN. Protocol for the differentiation of human alveolar epithelial type I cells from pluripotent stem cell-derived type II-like cells. STAR Protoc. 2025 Mar 21; 6(1):103667. PMID: 40048418.
Published on 3/4/2025Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC. Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2419620122. PMID: 40035769.
Published on 12/12/2024Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Ahmed DW, Spencer RC, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. Stem Cell Reports. 2025 Jan 14; 20(1):102376. PMID: 39672155.
Published on 10/15/2024Tang X, Wei W, Sun Y, Weaver TE, Nakayasu ES, Clair G, Snowball JM, Na CL, Apsley KS, Martin EP, Kotton DN, Alysandratos KD, Huo J, Molkentin JD, Gower WA, Lin X, Whitsett JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. J Clin Invest. 2024 Oct 15; 134(23). PMID: 39405113.
Published on 5/7/2024Hurley K, Ozaki M, Philippot Q, Galvin L, Crosby D, Kirwan M, Gill DR, Alysandratos KD, Jenkins G, Griese M, Nathan N, Borie R. A roadmap to precision treatments for familial pulmonary fibrosis. EBioMedicine. 2024 Jun; 104:105135. PMID: 38718684.
Published on 4/19/2024Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN. Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell. 2024 May 02; 31(5):657-675.e8. PMID: 38642558.
Published on 3/15/2024Basil MC, Alysandratos KD, Kotton DN, Morrisey EE. Lung repair and regeneration: Advanced models and insights into human disease. Cell Stem Cell. 2024 Apr 04; 31(4):439-454. PMID: 38492572.
Published on 1/1/2024Shankar DA, Hawkins F, Alysandratos KD, Wilson KC, Walkey AJ, Bosch NA, Law AC. Uptake of Antifibrotics for Patients with Idiopathic Pulmonary Fibrosis: 2016-2022. Ann Am Thorac Soc. 2024 Jan; 21(1):170-173. PMID: 37879035.
Media Mentions
Published on 10/17/2024
Global Biopharma Giant GSK and BU Announce Collaboration to Pioneer New Lung Disease Treatments
Published on 9/1/2021
Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases
View full list of 2 media mentions.