John L. Berk MD
Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
Graduate Faculty (Primary Mentor of Grad Students)
72 E. Concord Street | (617) 358-4774jberk@bu.edu
john.berk@bmc.org

Sections
Pulmonary, Allergy, Sleep & Critical Care Medicine
Centers
Pulmonary Center
Amyloidosis Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Expertise in Amyloidosis with specific emphasis in Familial and localized amyloid disease; pulmonary fibrosis.
Education
MD, Case Western Reserve University, 1983
Biology, BA, Wesleyan University, 1978
Publications
Coelho T, Waddington Cruz M, Chao CC, Parman Y, Wixner J, Weiler M, Barroso FA, Dasgupta NR, Jung SW, Schneider E, Viney NJ, Dyck PJB, Ando Y, Gillmore JD, Khella S, Gertz MA, Obici L, Berk JL. Characteristics of Patients with Hereditary Transthyretin Amyloidosis-Polyneuropathy (ATTRv-PN) in NEURO-TTRansform, an Open-label Phase 3 Study of Eplontersen. Neurol Ther. 2023 Feb; 12(1):267-287. PMID: 36525140.
Published on 11/29/2022Tsai FJ, Nelson LT, Kline GM, Jäger M, Berk JL, Sekijima Y, Powers ET, Kelly JW. Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange. Amyloid. 2022 Nov 29; 1-5. PMID: 36444793.
Published on 11/16/2022Brannagan TH, Berk JL, Gillmore JD, Maurer MS, Waddington-Cruz M, Fontana M, Masri A, Obici L, Brambatti M, Baker BF, Hannan LA, Buchele G, Viney NJ, Coelho T, Nativi-Nicolau J. Liver-directed drugs for transthyretin-mediated amyloidosis. J Peripher Nerv Syst. 2022 Dec; 27(4):228-237. PMID: 36345805.
Published on 10/26/2022Prokaeva T, Klimtchuk ES, Feschenko P, Spencer B, Cui H, Burks EJ, Aslebagh R, Muneeruddin K, Shaffer SA, Varghese E, Berk JL, Connors LH. An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis. Amyloid. 2022 Oct 26; 1-12. PMID: 36286264.
Published on 9/18/2022Quan D, Obici L, Berk JL, Ando Y, Aldinc E, White MT, Adams D. Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial. Amyloid. 2023 Mar; 30(1):49-58. PMID: 36120830.
Published on 8/24/2022Alreshq R, Cozzolino M, Lilleness B, Pipilas A, Mendelson L, Joshi T, Muralidhar V, Guardino E, Berk JL, Siddiqi OK, Gopal DM, Sanchorawala V, Ruberg FL. Light Chain Testing Abnormalities Among Patients With Transthyretin Amyloid Cardiomyopathy Referred for Technetium-99m Pyrophosphate Imaging. Am J Cardiol. 2022 Oct 15; 181:105-112. PMID: 36028388.
Published on 7/31/2022Brannagan TH, Coelho T, Wang AK, Polydefkis MJ, Dyck PJ, Berk JL, Drachman B, Gorevic P, Whelan C, Conceição I, Plante-Bordeneuve V, Merlini G, Obici L, Plana JMC, Gamez J, Kristen AV, Mazzeo A, Gentile L, Narayana A, Olugemo K, Aquino P, Benson MD, Gertz M. Long-term efficacy and safety of inotersen for hereditary transthyretin amyloidosis: NEURO-TTR open-label extension 3-year update. J Neurol. 2022 Dec; 269(12):6416-6427. PMID: 35908242.
Published on 7/23/2022Adams D, Tournev IL, Taylor MS, Coelho T, Planté-Bordeneuve V, Berk JL, González-Duarte A, Gillmore JD, Low SC, Sekijima Y, Obici L, Chen C, Badri P, Arum SM, Vest J, Polydefkis M. Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial. Amyloid. 2023 Mar; 30(1):1-9. PMID: 35875890.
Published on 7/5/2022Gustine JN, Staron A, Szalat RE, Mendelson LM, Joshi T, Ruberg FL, Siddiqi O, Gopal DM, Edwards CV, Havasi A, Kaku M, Lau KHV, Berk JL, Sloan JM, Sanchorawala V. Predictors of hematologic response and survival with stem cell transplantation in AL amyloidosis: A 25-year longitudinal study. Am J Hematol. 2022 Sep; 97(9):1189-1199. PMID: 35731907.
Published on 6/2/2022Ando Y, Adams D, Benson MD, Berk JL, Planté-Bordeneuve V, Coelho T, Conceição I, Ericzon BG, Obici L, Rapezzi C, Sekijima Y, Ueda M, Palladini G, Merlini G. Guidelines and new directions in the therapy and monitoring of ATTRv amyloidosis. Amyloid. 2022 Sep; 29(3):143-155. PMID: 35652823.
Media Mentions
Published on 9/13/2022
Patisiran beneficial in ATTR amyloidosis with cardiomyopathy
Published on 9/8/2022
Alnylam details anticipated results from heart disease drug trial`
Published on 8/3/2022
Alnylam’s stock soars by nearly 50 percent on trial results for heart drug
Published on 6/26/2021
Intellia, with first results, delivers a 'landmark' for CRISPR gene editing
Published on 6/26/2021
Published on 3/12/2021
Published on 9/22/2020
Trial Data Provide Proof-of-concept for CRX-1008 as Leptomeningeal FAP Treatment
Published on 8/27/2018
Eyeing Approval, Pfizer Touts Tafamidis Data but Omits Key Details
Published on 8/3/2018
Patients Have “Fingers Crossed” As Alnylam Awaits Historic FDA Decision
View full list of 9 media mentions.