John L. Berk, M.D.

Faculty and Fellows


Associate Professor of Medicine
Director, Bronchoscopy Service, BMC
Associate Director, Pulmonary & Critical Care Medicine Fellowship
Associate Clinical Director, Amyloid Treatment and Research Program
Director, Amyloid Airway Clinic

Medical School: Case Western Reserve University School of Medicine (CWRU)
Internship: University Hospitals, CWRU
Residency: University Hospitals, CWRU
Fellowship: Pulmonary Fellowship, Boston University School of Medicine
Other Post-doctoral Fellowships/Training: Research Associate, Howard Hughes Medical Institute

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine

Special Interests:

Research:

  • PI, Diflunisal Trial – FDA & NIH funded
  • Radiotherapy for tracheobronchial amyloidosis
  • Modulation of extracellular matrix gene expression by hypoxia

Clinical:

  • Lung manifestations of localized & systemic amyloidoses
  • Pulmonary fibrosis

John Berk attends on the Pulmonary Consult service and in the Medical Intensive Care Units. He directs the Bronchoscopy Service at Boston Medical Center, and is the Pulmonary Medicine and Critical Care expert of the multi-disciplinary Amyloid Treatment and Research Program, an internationally recognized center of excellence.

Dr. Berk is the Principal Investigator for an NIH & FDA funded international trial designed to establish whether diflunisal (Dolobid®) prevents neurologic disease progression in patients with familial amyloidotic polyneuropathy (FAP).

Selected Publications:

  1. Berk JL, Wiesman JF, Skinner M, and V Sanchorawala. Diaphragm paralysis in primary systemic amyloidosis. Amyloid Journal 12 (3):193-6, 2005
  2. Berk JL. Pleural effusions in systemic amyloidosis. Curr Opin Pulm Med 11(4):324-28, 2005
  3. Berk, J.L., Hatch, C.A., Morris, S.M., Goldstein, R.H., and Stone, P.J. Hypoxia inhibits repair of elastin fibers by interstitial lung fibroblasts. Am. J. Physiol. 289 (6):L931-6, 2005
  4. Skinner M, Sanchorawala V, Seldin DC, Dember LM, Falk RH, Berk JL, Anderson JJ, O’Hara C, Finn KT, Libbey CA, Wiesman J, Quillen K, Swan N, Wright DG. High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study. Ann Intern Med. 2004 Jan 20; 140(2):85-93.
  5. Seldin DC, Anderson JJ, Sanchorawala V, Malek K, Wright DG, Quillen K, Finn KT, Berk JL, Dember LM, Falk RH, Skinner M. Improvement in Quality Of Life of Patients With AL Amyloidosis Treated With High Dose Melphalan and Autologous Stem Cell Transplantation. Blood 104 (6): 1888-93, 2004
  6. Seldin, D.C., Choufani, E.B., Dember, L.M., Wiesman, J.F., Berk, J.L., Falk, R.H., O’Hara, C., Fennessey, S., Finn, K.T., Wright, D.G., Skinner, M., and V. Sanchorawala. Tolerability and efficacy of thalidomide for the treatment of patients with light chain-associated (AL) amyloidosis. Clinical Lymphoma 3(4):241-6, 2003.
  7. Berk, J.L., Keane, J., Seldin, D.C., Sanchorawala, V., Koyama, J., Dember, L.M., and R.H. Falk. Persistent pleural effusions in AL amyloidosis: Etiology and prognosis. Chest 124 (3):969-77, 2003. Berk, J.L., O’Regan, A., and M. Skinner. Pulmonary and tracheobronchial amyloidosis. Joseph P. Lynch, III, Editor. Seminars in Respiratory and Critical Care Medicine 23:155-65, 2002.
  8. Sanchorawala, V., Wright, D.G., Seldin, D.C., Falk, R.H., Berk, J.L., Dember, L.M., Finn, K. and M. Skinner. Low-dose continuous oral melphalan for the treatment of primary (AL) systemic amyloidosis. British Journal of Hematology 117 (4):886-889, 2002.
  9. Kuang, P-P., Berk, J.L., Rishikof, D.C., Foster, J.A., Ricupero, D.A., and R.H. Goldstein. NF-kB induced by IL-1? inhibits elastin transcription and myofibroblast phenotype. Am J Cell Physiol. 2002 Jul;283(1):C58-65.

Selected Reprints:

  1. Diaphragm paralysis in primary systemic amyloidosis
  2. Hypoxia suppresses elastin repair by rat lung fibroblasts
  3. Persistent Pleural Effusions in Primary Systemic Amyloidosis*
  4. Pulmonary and Tracheobronchial Amyloidosis

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