Jessica L. Fetterman PhD

Assistant Professor, Vascular Biology

75 E. Newton St | (617) 358-7544
jefetter@bu.edu

Sections

Vascular Biology

Centers

Whitaker Cardiovascular Institute

Framingham Heart Study

Evans Center for Interdisciplinary Biomedical Research

Biography

Dr. Fetterman is a basic and translational scientist studying the intersections of mitochondrial physiology, mitochondrial genetic epidemiology, and cardiovascular disease. Her work focuses on the contribution of mitochondrial genetic variation and abnormalities to cardiovascular disease in the presence of risk factors, including tobacco product use and diabetes.

Using bioinformatics methods, Dr. Fetterman discovered that several select mitochondrial genetic variants are associated with non-invasive measures of vascular function within the Framingham Heart Study (FHS). Additionally, she has applied similar methodology to select mitochondrial single variant data within Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) to determine the associations of select mitochondrial genetic variants with cardiometabolic measures in collaboration with members of the mitochondrial genetics working group. Recently, Dr. Fetterman was awarded the competitive Trans-Omics Precision Medicine (TOPMed) Analytical Support Award for early career investigators to perform comprehensive bioinformatic annotation of the mitochondrial genetic variants within the TOPMed cohorts.

Dr. Fetterman also conducts research on the impact of new and emerging tobacco products on the vasculature, particularly studies designed to inform tobacco product regulation. Some of her recent work demonstrated that tobacco product flavoring additives induce vascular endothelial dysfunction, an early indicator of cardiovascular injury. She serves as an Associate Director of Education and Training within American Heart Association Tobacco Regulation and Addiction Center. Additionally, she is the Director for the Boston University Tobacco Regulatory Science Affinity Research Collaborative, which is designed to bring together multi-disciplinary teams of scientists within Boston University to increase our understanding of tobacco product use patterns and the impact of new and emerging tobacco products on human health and disease.

Websites

BU Profile

Tobacco Regulatory Science Affinity Research Collaborative

Fetterman Lab

iCAMP Program

Education

Pathology, PhD, University of Alabama at Birmingham

Microbiology, BA, Ohio Wesleyan University

Publications

Published on 7/17/2023

Rose JJ, Krishnan-Sarin S, Exil VJ, Hamburg NM, Fetterman JL, Ichinose F, Perez-Pinzon MA, Rezk-Hanna M, Williamson E. Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association. Circulation. 2023 Aug 22; 148(8):703-728. PMID: 37458106.

PubMed

Published on 6/29/2023

Brant LCC, Ribeiro AH, Pinto-Filho MM, Kornej J, Preis SR, Fetterman JL, Eromosele OB, Magnani JW, Murabito JM, Larson MG, Benjamin EJ, Ribeiro ALP, Lin H. Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings: The Framingham Heart Study. Circ Cardiovasc Qual Outcomes. 2023 Jul; 16(7):e009821. PMID: 37381910.

PubMed

Published on 6/10/2023

Li Y, Gray A, Xue L, Farb MG, Ayalon N, Andersson C, Ko D, Benjamin EJ, Levy D, Vasan RS, Larson MG, Rong J, Xanthakis V, Liu C, Fetterman JL, Gopal DM. Metabolomic Profiles, Ideal Cardiovascular Health, and Risk of Heart Failure and Atrial Fibrillation: Insights From the Framingham Heart Study. J Am Heart Assoc. 2023 Jun 20; 12(12):e028022. PMID: 37301766.

PubMed

Published on 5/11/2023

Booras A, Wiener RS, Maccarone J, Stokes AC, Fetterman JL, Hamburg NM, Singh J, Bulekova K, Kathuria H. A Longitudinal Study of Perceptions of the Massachusetts Menthol Ban and Its Impact on Smoking Behaviors among Marginalized Individuals. Int J Environ Res Public Health. 2023 May 11; 20(10). PMID: 37239518.

PubMed

Published on 4/27/2023

Xue L, Moreira JD, Smith KK, Fetterman JL. The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome. Biomolecules. 2023 Apr 27; 13(5). PMID: 37238623.

PubMed

Published on 3/14/2023

Wu J, Origgi JM, Ranker LR, Bhatnagar A, Robertson RM, Xuan Z, Wijaya D, Hong T, Fetterman JL. Compliance With the US Food and Drug Administration's Guidelines for Health Warning Labels and Engagement in Little Cigar and Cigarillo Content: Computer Vision Analysis of Instagram Posts. JMIR Infodemiology. 2023; 3:e41969. PMID: 37113379.

PubMed

Published on 1/26/2023

Majid S, Weisbrod RM, Fetterman JL, Keith RJ, Rizvi SHM, Zhou Y, Behrooz L, Robertson RM, Bhatnagar A, Conklin DJ, Hamburg NM. Pod-based e-liquids impair human vascular endothelial cell function. PLoS One. 2023; 18(1):e0280674. PMID: 36701344.

PubMed

Published on 12/11/2022

Amraotkar AR, Owolabi US, Malovichko MV, Majid S, Weisbrod RM, Benjamin EJ, Fetterman JL, Hirsch GA, Srivastava S, Poudel R, Robertson RM, Bhatnagar A, Hamburg NM, Keith RJ. Association of electronic cigarette use with circulating angiogenic cell levels in healthy young adults: Evidence for chronic systemic injury. Vasc Med. 2023 Feb; 28(1):18-27. PMID: 36503365.

PubMed

Published on 11/2/2022

Moreira JD, Gower AC, Xue L, Alekseyev Y, Smith KK, Choi SH, Ayalon N, Farb MG, Tenan K, LeClerc A, Levy D, Benjamin EJ, Lenburg ME, Mitchell RN, Padera RF, Fetterman JL, Gopal DM. Systematic dissection, preservation, and multiomics in whole human and bovine hearts. Cardiovasc Pathol. 2023; 63:107495. PMID: 36334690.

PubMed

Published on 7/20/2022

Schwartz B, Gjini P, Gopal DM, Fetterman JL. Inefficient Batteries in Heart Failure: Metabolic Bottlenecks Disrupting the Mitochondrial Ecosystem. JACC Basic Transl Sci. 2022 Nov; 7(11):1161-1179. PMID: 36687274.

PubMed

View full list of 55 publications.