George T. O’Connor MD

Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Member, Genome Science Institute

72 E. Concord Street | (617) 638-4470
George O'Connor
Sections

Pulmonary, Allergy, Sleep & Critical Care Medicine

Centers

Pulmonary Center

Framingham Heart Study

Evans Center for Interdisciplinary Biomedical Research

Biography

My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I am currently a multiple PI and Co-director of the NHLBI's Framingham Heart Study, and I am a co-investigator in the Risk Underlying Rural Areas Longitudinal (RURAL) Cohort Study. I am the Boston University-Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, including the All of Us Research Program, the Childhood Asthma in Urban Settings (CAUSE) consortium, and the Vitamin D Antenatal Asthma Reduction Trial (VDAART. I have led the BU-BMC site of clinical trials in children and adolescents with asthma and the Urban Environment and Childhood Asthma (URECA) birth-cohort study examining the risk factors for asthma and allergy in urban settings. l conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. My research spans disciplines including adult medicine, pediatrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Education

MD, Boston University School of Medicine

MS, Harvard School of Public Health

BA, Boston University

Publications

Published on 1/2/2025

Togias A, Gergen PJ, Liu AH, Kim H, Wood RA, O'Connor GT, Makhija M, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Lamm C, Bacharier LB, Patel SJ, Gern JE, Jackson DJ, Visness CM, Calatroni A, Busse WW. Rhinoconjunctivitis symptoms in children and adolescents with asthma: Longitudinal clustering analysis. J Allergy Clin Immunol. 2025 Jan 02. PMID: 39755282.

Published on 12/6/2024

Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Cumhur DY, Heard-Costa NL, Orchard P, Carson AP, Raffield LM, Reiner A, Li Y, O'Connor G, Murabito JM, Munson P, Levy D. Integrating Whole Genome and Transcriptome Sequencing to Characterize the Genetic Architecture of Isoform Variation and its Implications for Health and Disease. medRxiv. 2024 Dec 06. PMID: 39677465.

Published on 11/27/2024

Patchen BK, Zhang J, Gaddis N, Bartz TM, Chen J, Debban C, Leonard H, Nguyen NQ, Seo J, Tern C, Allen R, DeMeo DL, Fornage M, Melbourne C, Minto M, Moll M, O'Connor G, Pottinger T, Psaty BM, Rich SS, Rotter JI, Silverman EK, Stratford J, Graham Barr R, Cho MH, Gharib SA, Manichaikul A, North K, Oelsner EC, Simonsick EM, Tobin MD, Yu B, Choi SH, Dupuis J, Cassano PA, Hancock DB. Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline. medRxiv. 2024 Nov 27. PMID: 39649580.

Published on 11/27/2024

Brunwasser SM, Gebretsadik T, Satish A, Cole JC, Dupont WD, Joseph C, Bendixsen CG, Calatroni A, Arbes SJ, Fulkerson PC, Sanders J, Bacharier LB, Camargo CA, Johnson CC, Furuta GT, Gruchalla RS, Gupta RS, Khurana Hershey GK, Jackson DJ, Kattan M, Liu A, O'Connor GT, Rivera-Spoljaric K, Phipatanakul W, Rothenberg ME, Seibold MA, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Hartert TV. Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children. Prev Med Rep. 2025 Jan; 49:102936. PMID: 39697187.

Published on 11/22/2024

Aggarwal M, Hwang SJ, Lee DH, Huan T, McNeill JN, Courchesne P, Joehanes R, Ho JE, Dupuis J, Hedman ÅK, O'Connor G, Levy D. Plasma Protein Biomarkers of Spirometry Measures of Impaired Lung Function. Chest. 2024 Nov 22. PMID: 39580111.

Published on 10/24/2024

Bhatt SP, Wu C, Sun Y, Balte PP, Schwartz JE, Divo MJ, Jaeger BC, Chaves PH, Couper D, Jacobs DR, Lloyd-Jones D, Kalhan R, Newman AB, O'Connor GT, Umans JG, White WB, Yende S, Oelsner EC. Low Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality. Ann Am Thorac Soc. 2024 Oct 24. PMID: 39447115.

Published on 10/7/2024

Fulkerson PC, Lussier SJ, Bendixsen CG, Castina SM, Gebretsadik T, Marlin JS, Russell PB, Seibold MA, Everman JL, Moore CM, Snyder BM, Thompson K, Tregoning GS, Wellford S, Arbes SJ, Bacharier LB, Calatroni A, Camargo CA, Dupont WD, Furuta GT, Gruchalla RS, Gupta RS, Hershey GK, Jackson DJ, Johnson CC, Kattan M, Liu AH, Murrison L, O'Connor GT, Phipatanakul W, Rivera-Spoljaric K, Rothenberg ME, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Hartert TV, Heros Study Team OBOT. Human Epidemiology and Response to SARS-CoV-2 (HEROS): objectives, design, and enrollment results of a 12-city remote observational surveillance study of households with children, using direct-to-participant methods. Am J Epidemiol. 2024 Oct 07; 193(10):1329-1338. PMID: 38775275.

Published on 10/1/2024

Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW, McDonald MN, Divo MJ, Silverman EK, Celli BR, O'Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 Oct 01; 210(7):890-899. PMID: 38471013.

Published on 9/20/2024

Ramratnam SK, Johnson M, Visness CM, Calatroni A, Altman MC, Janczyk T, McCauley KE, Schachtschneider C, Fujimura KE, Fadrosh DW, Lynch SV, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Gergen PJ, Jackson DJ, Togias A, Gern JE. Clinical and molecular analysis of longitudinal rhinitis phenotypes in an urban birth cohort. J Allergy Clin Immunol. 2024 Sep 20. PMID: 39307288.

Published on 7/1/2024

Havens TN, LeBeau P, Calatroni A, Gern JE, O'Connor GT, Wood RA, Lamm C, Krouse RZ, Visness CM, Gergen PJ, Jackson DJ, Bacharier LB. Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children. Pediatr Allergy Immunol. 2024 Jul; 35(7):e14197. PMID: 39016335.

View full list of 355 publications.