Frederick Lief Ruberg MD – Chief, Cardiovascular Medicine
Professor, Cardiovascular Medicine
Professor, Radiology
75 E. Newton St | (617) 638-8968f.ruberg@bmc.org
frederick.ruberg@bmc.org
frruberg@bu.edu
Sections
Cardiovascular Medicine
Centers
Whitaker Cardiovascular Institute
Amyloidosis Center
Biography
Frederick L. Ruberg, MD is the Thomas J. Ryan Professor of Cardiovascular Medicine and Professor of Radiology at Boston University (BU) Chobanian & Avedisian School of Medicine and Chief, Section of Cardiovascular Medicine at Boston Medical Center (BMC). Dr. Ruberg attended the University of Pennsylvania Perelman School of Medicine, completed internal medicine training at Brigham and Women’s Hospital, cardiovascular disease fellowship at Boston Medical Center/Boston University School of Medicine, followed by a fellowship in cardiovascular magnetic resonance (CMR) imaging at Beth Israel Deaconess Medical Center in Boston. Committed to research mentorship, he co-directs Workforce Development for the Boston University Clinical and Translational Science Institute (CTSI) and serves as Senior Associate Editor of Circulation: Cardiovascular Imaging. Dr. Ruberg is a Fellow of the American Heart Association and a member of the Association of University Cardiologists. His clinical and research expertise primarily involves cardiac imaging and infiltrative heart disease focused on improving the recognition and care of patients with cardiac amyloidosis, particularly that owing to ATTR and the hereditary genetic TTR variant Val122Ile (or V142I). He is an investigator on numerous NIH-funded awards including co-PI of the $7.2m NHLBI-funded Screening for Cardiac Amyloidosis with Nuclear Imaging (SCAN-MP, R01 HL139671) study. An active clinical cardiologist at the BU Amyloidosis Center, he has also contributed and co-directed numerous collaborative clinical guidelines initiatives, including mostly recently the 2023 the ACC Expert Consensus Decision Pathway document on The Comprehensive Multidisciplinary Care of Patient with Cardiac Amyloidosis. Dr. Ruberg has been recognized with mentorship (2017) and citizenship (2022) awards from the BU Department of Medicine.
Other Positions
Education
Medicine-Internal, MD, University of Pennsylvania School of Medicine
Psychology, BA, Haverford College
Publications
Slivnick JA, Lim SC, Randazzo M, Maurer MS, Helmke S, Scherrer-Crosbie M, Vakilpour A, Zareba KM, Goyal A, Cheng R, Wakamatsu N, Kitano T, Takeuchi M, Hotta VT, Vieira MLC, Elissamburu P, Ronderos RE, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Addetia K, Cotella J, Ruberg FL, Frost M, Fontana M, Lam Su Ping C, Lang RM, Asch FM. Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection. Circ Cardiovasc Imaging. 2026 May 27; e019610. PMID: 42200278.
Published on 5/1/2026Ambardekar AV, Sarswat N, Wright R, Berk J, Davis MK, Garcia-Pavia P, Gillmore JD, Grodin JL, Mitchell JD, Mooney D, Nativi-Nicolau J, Poulsen SH, Ruberg FL, Chen C, Ji A, Siddhanti S, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Maurer MS, Cheng RK. Acoramidis, Serum Transthyretin, and Cardiovascular Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights From the ATTRibute-CM Trial. J Card Fail. 2026 May; 32(5):864-876. PMID: 42128580.
Published on 4/29/2026McMenamin KJ, Teruya S, Slivnick J, Alreshq R, Ullah I, Fine D, Elzieny AA, Helmke S, Gallegos C, Miller EJ, Asch FM, Hasan S, Maurer MS, Ruberg FL. Fully Automated vs. Human Echocardiogram Interpretation in Transthyretin Amyloid Cardiomyopathy: The SCAN-MP Study. J Am Soc Echocardiogr. 2026 Apr 29. PMID: 42066965.
Published on 4/17/2026Berumen A, Staron A, Kalaitzidis G, Siddiqi OK, Gopal DM, Ruberg FL, Sanchorawala V. Evaluating AL-ISS within a BNP-Based Model for AL Amyloidosis in the Daratumumab Era. Blood Adv. 2026 Apr 17. PMID: 41995749.
Published on 2/1/2026Pandey S, Ruberg FL. A tale of two tracers-does one outperform the other? J Nucl Cardiol. 2026 Feb; 56:102621. PMID: 41771626.
Published on 1/1/2026Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M. Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension. JAMA Cardiol. 2026 Jan 01; 11(1):57-67. PMID: 41205147.
Published on 10/31/2025Kittleson MM, Ambardekar AV, Cheng RK, Griffin JM, Maurer MS, Nativi-Nicolau J, Ruberg FL. Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance. J Am Coll Cardiol. 2026 Feb 10; 87(5):549-565. PMID: 41171219.
Published on 10/22/2025Slivnick JA, Hawkes W, Oliveira J, Woodward G, Akerman A, Gomez A, Hamza I, Desai VK, Barrett-O'Keefe Z, Grogan M, Dispenzieri A, Scott CG, Davison HN, Cotella J, Maurer M, Helmke S, Scherrer-Crosbie M, Soltani M, Goyal A, Zareba KM, Cheng RK, Kirkpatrick JN, Kitano T, Takeuchi M, Tiemi Hotta V, Campos Vieira ML, Elissamburu P, Ronderos RE, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Patel AR, Addetia K, Ruberg FL, Randazzo M, Asch FM, O'Driscoll J, Al-Roub N, Strom JB, Kidd L, Cuddy S, Upton R, Lang RM, Pellikka PA. Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool. Eur Heart J. 2025 Oct 22; 46(40):4090-4101. PMID: 40631729.
Published on 10/10/2025Wees IR, Ayers C, Ruberg FL, Maurer MS, Brailovsky Y, Stern LK, Griffin JM, Khouri MG, Roth LR, Grodin JL. Clinical Implications of the P.V142I TTR Variant: Insights From CARS. JACC Heart Fail. 2026 Feb; 14(2):102704. PMID: 41074899.
Published on 10/1/2025Ruberg FL, Teruya S, Helmke S, Smiley DA, Fine D, Kurian D, Raiszadeh F, Prokaeva T, Spencer B, Wong S, Pandey S, Blaner WS, DeLuca A, Johnson LL, Kinkhabwala MP, Leb J, Mintz A, LaValley MP, Einstein AJ, Cohn E, Gallegos C, Murtagh G, Kelly JW, Miller EJ, Maurer MS. Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. JAMA Cardiol. 2025 Oct 01; 10(10):1034-1043. PMID: 40928765.
Media Mentions
Published on 9/23/2025
ATTR-CA Identified as Major Cause of Heart Failure in Older Black Adults
Published on 7/1/2024
Concerning link discovered between heart disease and disappearance of the Y chromosome
Published on 7/1/2024
New study shows a relationship between heart disease and spontaneous loss of Y chromosome
Published on 6/27/2024
Published on 5/8/2024
6 Signs of Heart Problems Even Young People Should Know
Published on 8/17/2023
Staying Active Safely: Exercise Tips If You Have ATTR-CM
Published on 1/7/2022
Heart Failure Imaging: Where Are We Now?
Published on 9/4/2019
Study aims to achieve earlier diagnosis of ATTR cardiac amyloidosis in minority populations
Published on 6/4/2019
Cardiac Transthyretin Amyloidosis Often Diagnosed Late
Published on 10/15/2018
Carpal Tunnel Surgery a Chance to Catch Amyloid Heart Disease
View full list of 10 media mentions.