Frederick Lief Ruberg, MD

Associate Professor, Medicine

Frederick Ruberg
(617) 638-8968
75 E. Newton St Collamore Building


Dr. Ruberg’s clinical and research expertise is in the field of cardiac imaging including echocardiography, cardiovascular magnetic resonance imaging (MRI), and cardiac computed tomography (CT). Dr. Ruberg’s research interest is in the application of MRI-based techniques, including MR spectroscopy, to quantify lipid (fat) deposition within the heart and vasculature as it relates to cardiac and vascular dysfunction. He also has a strong interest in amyloid cardiomyopathy, and the utility of cardiac MR in the diagnosis and management of this disease. He has collaborations involving investigators in cardiovascular medicine, biophysics, geriatrics, cardiac surgery, and hematology/oncology.

Other Positions

  • Associate Professor, Radiology, Boston University School of Medicine
  • Program Director, Pilot Translational & Clinical Studies Program, Clinical and Translational Science Institute, Boston University School of Medicine
  • Active Staff Privileges, Medicine, Boston Medical Center


  • University of Pennsylvania School of Medicine, MD
  • Haverford College, BA


  • Published on 10/20/2017

    Arvanitis M, Chan GG, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure. Amyloid. 2017 Dec; 24(4):253-255. PMID: 29052438.

    Read at: PubMed
  • Published on 9/1/2017

    Salinaro F, Meier-Ewert HK, Miller EJ, Pandey S, Sanchorawala V, Berk JL, Seldin DC, Ruberg FL. Longitudinal systolic strain, cardiac function improvement, and survival following treatment of light-chain (AL) cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2017 Sep 01; 18(9):1057-1064. PMID: 27965280.

    Read at: PubMed
  • Published on 7/24/2017

    Arun M, Brauneis D, Doros G, Shelton AC, Sloan JM, Quillen K, Ruberg FL, Sanchorawala V, Varga C. The incidence of atrial fibrillation among patients with AL amyloidosis undergoing high-dose melphalan and stem cell transplantation: experience at a single institution. Bone Marrow Transplant. 2017 Sep; 52(9):1349-1351. PMID: 28737773.

    Read at: PubMed
  • Published on 7/13/2017

    Siddiqi OK, Ruberg FL. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2017 Jul 13. PMID: 28739313.

    Read at: PubMed
  • Published on 6/21/2017

    Siddiqi OK, Ruberg FL. Challenging the myths of cardiac amyloidosis. Eur Heart J. 2017 Jun 21; 38(24):1909-1912. PMID: 28444296.

    Read at: PubMed
  • Published on 3/15/2017

    Ruberg FL. Cardiac Amyloidosis: A Zebra Hiding in Plain Sight? Circ Cardiovasc Imaging. 2017 Mar; 10(3):e006186. PMID: 28298289.

    Read at: PubMed
  • Published on 3/1/2017

    Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Mar 01; 2(3):305-313. PMID: 28196196.

    Read at: PubMed
  • Published on 3/1/2017

    Di Carli MF, Davidoff R, Beerbaum P, Dorbala S, Gillam LD, Hoffmann U, Raman SV, Ruberg FL. Editor's Note. Circ Cardiovasc Imaging. 2017 Mar; 10(3). PMID: 28289023.

    Read at: PubMed
  • Published on 3/1/2017

    Arvanitis M, Simon S, Chan G, Fine D, Beardsley P, LaValley M, Jacobson D, Koch C, Berk JL, Connors LH, Ruberg FL. Retinol binding protein 4 (RBP4) concentration identifies V122I transthyretin cardiac amyloidosis. Amyloid. 2017 Mar; 24(sup1):120-121. PMID: 28434357.

    Read at: PubMed
  • Published on 3/1/2017

    Maurer M, Lousada I, Hanna M, Ruberg F, Mohty D, Dispenzieri A, Liedtke M, Paulson I, Vest J, Grogan M. Recommendations from the Amyloidosis Research Consortium Educational Roundtable at the American College of Cardiology Annual Meeting, 1 April 2016. Amyloid. 2017 Mar; 24(sup1):165-166. PMID: 28434366.

    Read at: PubMed

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