Felicia Chen MD

Assistant Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Courtesy Staff Privileges, Medicine

72 E. Concord Street | (617) 358-1197
Felicia Chen

Pulmonary, Allergy, Sleep & Critical Care Medicine


Pulmonary Center

Evans Center for Interdisciplinary Biomedical Research


Dr. Chen's laboratory projects focus on retinoic acid biology in healthy and diseased lungs. She uses a multifaceted approach to knock down retinoic acid signals in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modifications. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) lung microbiome, 3) embryonic airway epithelial specification, and 4) matrix fibroblast activation.

Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung homeostasis
-Lung injury and repair
-Fibrotic lung diseases


MD, Albany Medical College, 1998

BA, Johns Hopkins University, 1994


Published on 1/1/2020

Marquez HA, Chen F. Retinoic Acid Signaling and Development of the Respiratory System. Subcell Biochem. 2020; 95:151-174. PMID: 32297299.

Published on 5/13/2019

Norman TA, Gower AC, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019; 14(5):e0216795. PMID: 31083674.

Published on 8/23/2018

Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16). PMID: 30135301.

Published on 9/18/2017

Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925.

Published on 8/11/2016

Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.

Published on 1/1/2015

Chen F, Cardoso WV. Culture of mouse embryonic foregut explants. Methods Mol Biol. 2015; 1189:163-9. PMID: 25245693.

Published on 1/9/2014

Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11. PMID: 24401276.

Published on 5/17/2010

Chen F, Cao Y, Qian J, Shao F, Niederreither K, Cardoso WV. A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium. J Clin Invest. 2010 Jun; 120(6):2040-8. PMID: 20484817.

Published on 12/1/2009

Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 1; 6(7):558-63. PMID: 19934349.

Published on 8/11/2008

Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV. Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem. 2008 Oct 24; 283(43):29532-44. PMID: 18694942.

View full list of 13 publications.