Darrell Nelson Kotton MD
Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine
Professor, Pathology & Laboratory Medicine
670 Albany St | (617) 414-2969dkotton@bu.edu

Sections
Pulmonary, Allergy, Sleep & Critical Care Medicine
Centers
Center for Regenerative Medicine
Pulmonary Center
Framingham Heart Study
Evans Center for Interdisciplinary Biomedical Research
Biography
Expertise includes: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.
Other Positions
Education
MD, Washington University School of Medicine, 1994
BA, University of Pennsylvania, 1989
Publications
Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659. PMID: 35749346.
Published on 4/15/2022Werder RB, Huang J, Abo KM, Hix OT, Minakin K, Alysandratos KD, Merritt C, Berthiaume K, Alber AB, Burgess CL, Kotton DN, Wilson AA. Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells. J Vis Exp. 2022 Apr 15; (182). PMID: 35499347.
Published on 3/30/2022Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature. 2022 Apr; 604(7904):120-126. PMID: 35355013.
Published on 3/22/2022Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 Mar 22; 7(6). PMID: 35315362.
Published on 3/4/2022Gil CH, Chakraborty D, Vieira CP, Prasain N, Calzi SL, Fortmann SD, Hu P, Banno K, Jamal M, Huang C, Sielski MS, Lin Y, Huang X, Dupont MD, Floyd JL, Prasad R, Longhini ALF, McGill TJ, Chung HM, Murphy MP, Kotton DN, Boulton ME, Yoder MC, Grant MB. Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice. Sci Adv. 2022 Mar 04; 8(9):eabm5559. PMID: 35245116.
Published on 2/21/2022Wang SW, Herriges MJ, Hurley K, Kotton DN, Klein AM. CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information. Nat Biotechnol. 2022 Feb 21. PMID: 35190690.
Published on 2/9/2022Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563. PMID: 35137631.
Published on 2/9/2022Miorin L, Mire CE, Ranjbar S, Hume AJ, Huang J, Crossland NA, White KM, Laporte M, Kehrer T, Haridas V, Moreno E, Nambu A, Jangra S, Cupic A, Dejosez M, Abo KA, Tseng AE, Werder RB, Rathnasinghe R, Mutetwa T, Ramos I, de Aja JS, de Alba Rivas CG, Schotsaert M, Corley RB, Falvo JV, Fernandez-Sesma A, Kim C, Rossignol JF, Wilson AA, Zwaka T, Kotton DN, Mühlberger E, García-Sastre A, Goldfeld AE. The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters. bioRxiv. 2022 Feb 09. PMID: 35169796.
Published on 2/8/2022Kotton DN, Nilsson M. Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration. Front Endocrinol (Lausanne). 2022; 13:848559. PMID: 35211095.
Published on 2/4/2022Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268. PMID: 35120176.
Media Mentions
Published on 2/9/2022
Ambitious Effort to Develop Lab-Grown Lungs Wins Paul G. Allen Frontiers Group Funding
Published on 9/23/2021
MED’s Biology of the Lung Funded through Its 50th—Yes, 50th—Year
Published on 9/1/2021
Modeling Inaccessible Cells from Induced Stem Cells Heralds Hope for Untreatable Lung Diseases
Published on 7/1/2021
BU awarded T32 grant to mentor research trainees in lung biology and pulmonary sciences
Published on 1/11/2021
How Coronavirus Damages Lung Cells within Mere Hours
Published on 12/22/2020
$2.4M NIH Grant Supports Boston Team Creating Cell Model for IPF
Published on 12/15/2020
CF Foundation Awards Research Projects to Advance Therapies for All CF Patients
Published on 9/28/2020
How Coronavirus Kickstarts Deadly Lung Inflammation
Published on 9/25/2020
Boston University Researchers Shed Light on How COVID Causes Fatal Lung Inflammation
Published on 9/24/2020
In Deadly COVID-19 Lung Inflammation, BU Researchers Discover a Culprit in NFkB Pathway
View full list of 16 media mentions.