Darrell Nelson Kotton MD

Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Professor, Pathology & Laboratory Medicine

670 Albany St
Darrell Kotton
Sections

Pulmonary, Allergy, Sleep & Critical Care Medicine

Centers

Center for Regenerative Medicine

Pulmonary Center

Framingham Heart Study

Evans Center for Interdisciplinary Biomedical Research

Biography

Darrell N. Kotton, MD is the founding director of the Center for Regenerative Medicine of Boston University and Boston Medical Center. He is a physician-scientist with attending physician duties in pulmonary and critical care medicine at Boston Medical Center and is the David C. Seldin Professor in the department of medicine and in the department of pathology and laboratory medicine at the Boston University Chobanian and Avedesian School of Medicine. Dr. Kotton is an Allen Distinguished Investigator, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. He is also an elected member of the American Society of Clinical Investigators and the Association of American Physicians. He leads a basic research laboratory, funded continuously by the NIH since 2004, focused on lung regeneration and stem cell biology, and he serves on the NIH’s National Heart Lung and Blood Institute’s Board of External Experts. He is the recipient of the American Thoracic Society’s “Recognition Award for Scientific Accomplishments” (2018), the AAMC inaugural national “Research Resources Sharing Award” (2017), the Alpha-1 Foundation’s “Researcher of the Year” (2013) and “Shillelagh” (2010) Awards, Boston University’s Graduate Medical Sciences Educator of the Year Award (2018), and the Robert Dawes Evans Senior Research Mentor Award from Boston University.

Expertise: Stem Cell Biology; iPS cells; Reprogramming; Gene Therapy; Lung Developmental Biology.

Other Positions

Education

MD, Washington University School of Medicine

BA, University of Pennsylvania

Publications

Published on 12/12/2024

Eiken MK, Childs CJ, Brastrom LK, Frum T, Plaster EM, Ahmed DW, Spencer RC, Shachaf O, Pfeiffer S, Levine JE, Alysandratos KD, Kotton DN, Spence JR, Loebel C. Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels. Stem Cell Reports. 2024 Dec 12; 102376. PMID: 39672155.

Published on 11/13/2024

Kohn A, Herriges MJ, Basak P, Ma L, Thapa BR, Kotton DN, Hawkins FJ. Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract. bioRxiv. 2024 Nov 13. PMID: 39605510.

Published on 11/8/2024

Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation. Am J Respir Crit Care Med. 2024 Nov 08. PMID: 39514838.

Published on 11/7/2024

Undeutsch HJ, Posabella A, Alber AB, Bawa PS, Villacorta-Martin C, Wang F, Ikonomou L, Kotton DN, Hollenberg AN. Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells. Stem Cell Reports. 2024 Dec 10; 19(12):1690-1705. PMID: 39515316.

Published on 11/5/2024

Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2024 Nov 05. PMID: 39501108.

Published on 10/15/2024

Tang X, Wei W, Sun Y, Weaver TE, Nakayasu ES, Clair G, Snowball JM, Na CL, Apsley KS, Martin EP, Kotton DN, Alysandratos KD, Huo J, Molkentin JD, Gower WA, Lin X, Whitsett JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. J Clin Invest. 2024 Oct 15; 134(23). PMID: 39405113.

Published on 6/17/2024

Gagnon KA, Huang J, Hix OT, Hui VW, Hinds A, Bullitt E, Eyckmans J, Kotton DN, Chen CS. Multicompartment duct platform to study epithelial-endothelial crosstalk associated with lung adenocarcinoma. APL Bioeng. 2024 Jun; 8(2):026126. PMID: 38911024.

Published on 4/20/2024

Tang W, Huang J, Pegoraro AF, Zhang JH, Tang Y, Bi D, Kotton DN, Guo M. Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres. bioRxiv. 2024 Apr 20. PMID: 38659777.

Published on 4/19/2024

Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN. Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell. 2024 May 02; 31(5):657-675.e8. PMID: 38642558.

Published on 3/28/2024

Rodriguez LR, Alysandratos KD, Katzen J, Murthy A, Barboza WR, Tomer Y, Acin-Perez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis. bioRxiv. 2024 Mar 28. PMID: 38585863.

View full list of 168 publications.