The Kotton Lab
The Kotton lab’s goal is advancing our understanding of lung disease and developmental biology with a focus on stem cell biology and gene therapy. We believe that novel treatments for many lung diseases can be realized based on a better understanding of how the lung develops as well as regenerates after lung injury.
We are particularly interested in understanding how lung cells decide and remember who they are. To this end, one focus of our group is defining the genomic and epigenomic programs that regulate lung cell fate. A longer term goal is the de novo generation of the full diversity of lung lineages and transplantable 3D lung tissues from pluripotent stem cells. For 10 years we have worked together with Drs. Andrew Wilson and Laertis Ikonomou as the “Kiwi” group, merging our finances, facilities, and group meetings to accomplish our shared mission of regenerating lung and other endodermal lineages. Our Principal Investigator, Dr. Darrell Kotton, also serves as the founding Director of the Center for Regenerative Medicine (CReM). Take a full tour of the CReM by clicking on our logo above.
New! See three recent examples of our published work here:
Have forty five minutes for an overview of our last decade? Listen here to Darrell’s ATS Discovery Series Lecture, “Lung Regeneration: An Achievable Mission.”
or read more about our Open Source Biology Philosophy or a recent interview on Darrell’s approach to sharing our cells