The Kotton Lab


Kotton lab 2016

The Kottcrmlogohion lab’s goal is advancing our understanding of lung disease and developmental biology with a focus on stem cell biology and gene therapy. We believe that novel treatments for many lung diseases can be realized based on a better understanding of how the lung develops as well as regenerates after lung injury.

We are particularly interested in understanding how lung cells decide and remember who they are. To this end, one focus of our group is defining the genomic and epigenomic programs that regulate lung cell fate. A longer term goal is the de novo generation of the full diversity of lung lineages and transplantable 3D lung tissues from pluripotent stem cells. For 10 years we have worked together with Drs. Andrew Wilson and Laertis Ikonomou as the “Kiwi” group, merging our finances, facilities, and group meetings to accomplished our shared mission of regenerating lung and other endodermal lineages. Read more about our Kiwi (Kotton-Wilson-Ikonomou) group here. Our PI, Dr. Darrell Kotton, also serves as the founding Director of the Center for Regenerative Medicine (CReM). Take a full tour of the CReM by clicking on our logo above.

Click here to see our home: the beautiful Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center

What do we do? Click here to read more about our project areas!  Have only a minute? see our latest pubmed entires here.

Have forty five minutes for an overview of our last decade, what we’ve learned from our friends, and where we’re going? Listen here to Darrell’s ATS Discovery Series Lecture, “Lung Regeneration: An Achievable Mission.”

Open Source Works! Click here to access:

our freely available iPS Cell Lines, Lentiviral Vectors, Bioinformatics Datasets, or Detailed Protocols

or read more about our Open Source Biology Philosophy

Derivation of Epithelium from Embryonic Stem Cells







Click the photo to see more


See all our latest news on our twitter feed here:  

April 16, 2017
Primary teaching affiliate
of BU School of Medicine