Selected Publications

Jacob et al. Cell Stem Cell 2017

See a comprehensive Pubmed listing of our publications.

  1. Burgess CL et al.  Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell.2024 Apr 15. PMID: 38642558
  2. Ma L et al. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 7;30(9):1199-1216.e7. PMID: 37625411
  3. Herriges MJ et al. Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice. Cell Stem Cell. 2023 Sep 7;30(9):1217-1234.e7. PMID: 37625412
  4. Alber AB et al. Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme. Nature Communications. 2023 Jun 13. PMID: 37311756. Click for pdf: Alber et al 2023.
  5. Alysandratos KD et al. Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells. JCI Insight. 2023 Jan 10. PMID: 36454643.  Click for pdf: Alysandratos et al 2023.
  6. Alysandratos KD et al. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Reports. 2021 Aug 31. PMID: 34469722.
  7. Hawkins FJ, Suzuki S, et al. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 Oct 19:S1934-5909(20)30492-6. PMID: 33098807. Click for pdf: Hawkins et al 2020
  8. Alysandratos KD, Herriges MJ, Kotton DN. Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annu Rev Physiol. 2020 Oct 19. doi: 10.1146/annurev-physiol-041520-092904. PMID: 33074772
  9. Jessie Huang, Kristy Abo, Rhiannon Werder, Adam Hume… Andrew Wilson, Elke Muhlberger et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020. Click for pdf: Huang et al 2020. Watch the movie! Jessie Huang’s and Adam Hume’s poster presentation video.
  10. Killian Hurley, Jun Ding et al. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell. Jan, 2020. Click for pdf: Hurley et al 2020
  11. Laertis Ikonomou et al. The in vivo Genetic Program Of Murine Primordial Lung Epithelial Progenitors. Nature Communications.  Jan, 2020. Click for pdf: Ikonomou et al 2020
  12. Jacob A, Vedaie M, Roberts DA, Thomas DC, Villacorta-Martin C, Alysandratos KD, Hawkins F, Kotton DN. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nature Protocols. Dec, 2019; 14:3303-3332.. Click for pdf: Jacob et al 2019.
  13. Jacob A et al. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.   Cell Stem Cell. Oct 5, 2017  PMID: 28965766. Click for pdf: Jacob et al 2017
  14. Hawkins F, Kramer P, Jacob A, Driver I, Tomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Ngyen S, Wong BG, Khalil AS, Huang SXL, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective Isolation of NKX2-1 Expressing Human Lung Progenitors Derived from Pluripotent Stem Cells. Journal of Clinical Investigation. May 2, 2017. doi: 10.1172/JCI89950. PMID: 28463226. Click for pdf: Hawkins et al JCI 2017
  15. McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017 Mar 22. PMID: 28366587. PMID: 28366587 . Click for pdf: McCauley et al 2017
  16. Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 5;17(5):527-42. doi: 10.1016/j.stem.2015.09.004. Epub 2015 Oct 22.PMID: 26593959
  17. Longmire T.A., Ikonomou L., Hawkins F., Christodoulou C., Cao Y., Jean J.C., Kwok L.W., Mou H., Rajagopal J., Shen S.S., Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DNEfficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012;10:398–411.