Andrew J. Henderson PhD
Professor, Infectious Diseases
Assistant Dean, Oral Health Sciences
650 Albany St | (617) 414-5240andrew.henderson@bmc.org
hender@bu.edu
Sections
Infectious Diseases
Centers
BU-BMC Cancer Center
Evans Center for Interdisciplinary Biomedical Research
Biography
Research in my laboratory focuses on cellular mechanisms that regulate HIV replication and transcription. Current projects include exploring how signaling influences HIV infection and latency, devising strategies for long-term repression of HIV provirus and characterizing the transcriptional status of HIV provirus in T cell and macrophage subsets. In addition, we are interested in mechanisms that contribute to HIV associated inflammation. I have served on NIH study sections and special emphasis panels and was a member and chair for the NIH AIDS Molecular and Cellular Biology Study Section. In addition to my research, I have always been proactive in undergraduate and graduate training developing and providing leadership for PhD pipeline programs, and training international researchers.
Other Positions
Education
Biomedical Sciences, PhD, University of California, Riverside
Biology, MS, University of California, Riverside
Biology, BS, University of California, Riverside
Publications
Skeete C, Sgambettera G, Gojanovich AD, He X, Bryant D, Yang M, Banerjee S, Quiñones-Molina AA, Akiyama H, Mostoslavsky G, Henderson AJ, Gummuluru S. Mu opioid receptor activation in microglia enhances HIV-1 infection and HIV-infection-induced inflammatory responses. Front Immunol. 2025; 16:1628872. PMID: 41122167.
Published on 9/8/2025Jalloh S, Hughes IK, Akiyama H, Gojanovich AD, Quiñones-Molina AA, Yang M, Henderson AJ, Mostoslavsky G, Gummuluru S. Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells. PLoS Biol. 2025 Sep; 23(9):e3003320. PMID: 40920844.
Published on 8/25/2025Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S. 5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5. bioRxiv. 2025 Aug 25. PMID: 40909469.
Published on 6/10/2025Ramaswamy S, Akiyama H, Berrigan J, Quiñones-Molina AA, Olson AJ, Chen Y, Liang Y, Henderson AJ, Asundi A, Sagar M, Gummuluru S. The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses. J Clin Invest. 2025 Aug 15; 135(16). PMID: 40493408.
Published on 5/9/2024Kilroy JM, Leal AA, Henderson AJ. Chronic HIV Transcription, Translation, and Persistent Inflammation. Viruses. 2024 May 09; 16(5). PMID: 38793632.
Published on 2/1/2023Basukala B, Rossi S, Bendiks S, Gnatienko N, Patts G, Krupitsky E, Lioznov D, So-Armah K, Sagar M, Cheng C, Henderson AJ. Virally Suppressed People Living with HIV Who Use Opioids Have Diminished Latency Reversal. Viruses. 2023 Feb 01; 15(2). PMID: 36851631.
Published on 9/23/2022Smith JL, Menzies AM, Cohen JV, Mut-Lloret M, Ozgun A, Spain L, Park J, Quach HT, Pallan L, McQuade J, Feng S, Sandhu S, Atkinson V, Tsai K, Long GV, Larkin J, Eroglu Z, Johnson DB, Sullivan R, Herkes GK, Henderson A, Carlino MS. Neurological adverse effects associated with anti-PD1 antibodies alone or in combination with ipilimumab: a multicenter case series. Melanoma Res. 2022 Dec 01; 32(6):451-459. PMID: 36164923.
Published on 6/28/2022Kuniholm J, Coote C, Henderson AJ. Defective HIV-1 genomes and their potential impact on HIV pathogenesis. Retrovirology. 2022 Jun 28; 19(1):13. PMID: 35764966.
Published on 5/31/2022He G, Dunn HP, Ahmad KE, Watson E, Henderson A, Tynan D, Leaney J, White AJ, Hewitt AW, Fraser CL. Fundoscopy use in neurology departments and the utility of smartphone photography: a prospective prevalence and crossover diagnostic accuracy study amongst neurology inpatients. Eur J Neurol. 2022 Aug; 29(8):2463-2472. PMID: 35531644.
Published on 3/24/2022Coombes ID, Legg A, Patterson T, Kelly T, Henderson A, Roberts JA. Oral antivirals for mild-moderate COVID-19: a panacea or a logistical and clinical conundrum? Aust Prescr. 2022 Apr; 45(2):67-68. PMID: 35592373.
Media Mentions
Published on 3/8/2021
Researchers identify basic mechanisms that regulate HIV expression
Published on 3/1/2020
BUSM Professors Receive $1.4 Million Grant
View full list of 2 media mentions.