Leukemia and Lymphoma Laboratory
Gerald V. Denis, Ph.D.
Associate Professor
Education:
Ph.D., University of California, Berkeley
Postdoc, University of Massachusetts Medical Center
General field of research:
Cancer
Affiliations other than medicine:
Evans Center for Interdisciplinary Biomedical Research
Department of Pharmacology
Hematology/Oncology Section
Program in Molecular Medicine
Obesity and Diabetes
Boston Obesity Nutrition Research Center
Flow Cytometry Core Facility
Contact information:
Office
Conte Building, K520
Phone: 617-414-1371
Lab
Phone: 617-414-1372
Fax: 617-638-5673
Research group information
Fangnian Wang, postdoc
Wanda Blanton, Immunology Training Program fellow
Anna Belkina, graduate student
Hongsheng Liu, research associate
Other research websites:
http://www.bumc.bu.edu/immunology/
http://www.bumc.bu.edu/hematology/hematology-training-grant/
Keywords:
Cancer, stem cells, cancer therapeutics, insulin resistance, obesity, chromatin
Summary of research interest:
The overall goal of my lab is to understand the fundamental mechanisms of transcriptional control of growth and development, and particularly, how chromatin-based disruptions of the eukaryotic cell cycle can lead to malignancy. We focus on the functions of the bromodomain protein Brd2. Results to date have broad significance for our understanding of adaptive immunity, B cell proliferation and non-Hodgkin’s lymphoma (NHL). New results with Brd2 knockdown models have important implications for obesity and insulin resistance.
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Recent publications:
Greenwald et al (2004) E-mu-BRD2 transgenic mice develop B cell lymphoma and leukemia. Blood 103: 1475–1484. PMID: 14563639
Sinha et al (2005) Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem. J. 387: 257–269. PMID: 15548137
Denis et al (2006) Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J. Proteome Res. 5: 502–511. PMID: 16512664
You et al (2006) The Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J. Virol. 80: 8909–8919. PMID: 16940503
Lenburg et al (2007) Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J. Biol. Chem. 282: 4803–4811. PMID: 17166848
Longe et al (2009) Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential. Int. J. Cancer. 124:473–482. PMID: 19003960
Romesser et al (2009) Development of a malignancy-associated proteomic signature for diffuse large B cell lymphoma. Am. J. Pathol. in press.
Technologies available for sharing upon request:
Retroviral injections and lentivirus production