BUMC Faculty Appointments and Promotions – December 2022

Professor

Gustavo Mostoslavsky, MD, PhD, Medicine/Gastroenterology and Microbiology, is a pioneer in nuclear reprogramming, establishing one of the first methodologies for the generation of induced Pluripotent Stem Cells (iPSC) and co-founder and co-director of the Center for Regenerative Medicine (CReM) at BU, a world recognized stem cell institution. His laboratory has published seminal discoveries describing the mechanisms of nuclear reprogramming and their use in cell lineage specification and disease modeling. He received the BU Innovator of the Year Award in 2017 and is recognized for his open-source approach to science, having shared his reagents with more than 1000 laboratories worldwide. More recently, he reported the use of human iPSC for disease modeling of the gastrointestinal tract, establishing a novel platform for the generation of intestinal organoids and studying mechanisms of intestinal epithelial injury by SARS-CoV-2 as well as liver damage by Ebola Virus. His lab recently demonstrated a novel role for Notch signaling in the specification of the T-cell lineage specification of human iPSC. Dr. Mostoslavsky’s work has led to two BU patents, which were licensed and commercialized.