Dr. Sharov is a recipient of the Mentored Research Scientist Development Award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH. Dr. Sharov is studying molecular mechanisms of skin development, with particular emphasis on the regulation and maintenance of adult stem cells in the skin. His research focuses on dissecting the signal transduction pathways which regulate stem cell quiescence to better understand how alterations in these signaling pathways contribute to melanoma and non-melanoma skin cancers. In addition, Dr. Sharov studies a role of higher-order chromatin organization in the process of pigmentation funded by NIH/NIAMS.
Vladimir Botchkarev, MD, PhD is Research Associate Professor in the Department of Dermatology. He received his medical training at Chuvash State University in Cheboksary, Russian and his doctoral training at People’s Friendship University in Moscow, Russia. He was a recipient of the Research Career Development Award from the Dermatology Foundation and Independent Scientist Award from the National Institutes of Health. He is also a recipient of the research grants from the NIAMS and NCI. His name was included in the books 2000 Outstanding Scientists of the 21st Century, Great Minds of the 21st Century and Who is Who in Medicine. His primary research interests are the molecular mechanisms of hair growth and pathobiology of different forms of hair loss.
Dr. Phillips has long been interested in aging, wound healing, chronic wounds, and the role of keratinocyte sheets and other bioengineered skin constructs for the treatment of chronic wounds. She has a national and international reputation in this field. Together with Dr. Gilchrest, she showed how allogeneic keratinocytes sheets applied to chronic wounds caused stimulation of resurfacing from the wound margins, acting as a pharmacological agents and not as cellular replacements. Therefore, frequent construct application was required. This key observation was transformative and led key biotechnological companies to develop clinical FDA-approved protocols to take this effect into account in multicenter trials.
The Falanga laboratory is a stem cell and molecular biological laboratory focused on cutaneous wound healing and translational research. Dr.Falanga has a well-recognized and established career in wound healing. He quickly became interested in TGF-β1, and worked closely and collaborated with Drs. Anita Roberts and Michael Sporn of NCI. His interest in growth factors led his lab to advances in both basic science and clinical research. He and members of his lab were the lead authors of the use of bioengineered skin in chronic wounds, the first such therapy approved by the FDA. Over the last few years, the focus has been on stem cells and their biology.