Wellington V. Cardoso, MD, PhD
Adjunct Professor, Medicine
Biography
My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Professor, Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine
Education
- Universidade de Brasília, MD
- Universidade de São Paulo, PhD
Publications
- Published on 2/1/2025
Makrides N, Sun E, Mir H, Jiang Z, Wu Y, Serra C, Cardoso WV, Shah NH, Zhang X. Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2. bioRxiv. 2025 Feb 01. PMID: 39974929.
Read at: PubMed - Published on 12/9/2024
Ke X, van Soldt B, Vlahos L, Zhou Y, Qian J, George J, Capdevila C, Glass I, Yan K, Califano A, Cardoso WV. Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. Dev Cell. 2024 Dec 09. PMID: 39667932.
Read at: PubMed - Published on 10/14/2024
Dirvin B, Noh H, Tomassoni L, Cao D, Zhou Y, Ke X, Qian J, Schotsaert M, García-Sastre A, Karan C, Califano A, Cardoso WV. Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium. bioRxiv. 2024 Oct 14. PMID: 39464067.
Read at: PubMed - Published on 7/15/2024
Mori M, Cardoso WV. Can a Rat Breathe through a Mouse's Lung? Am J Respir Crit Care Med. 2024 Jul 15; 210(2):133-134. PMID: 38701370.
Read at: PubMed - Published on 7/1/2024
Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335.
Read at: PubMed - Published on 11/22/2023
van Soldt BJ, Metscher BD, Richardson MK, Cardoso WV. Sox9 is associated with two distinct patterning events during snake lung morphogenesis. Dev Biol. 2024 Feb; 506:7-19. PMID: 37995917.
Read at: PubMed - Published on 11/9/2023
Neptune ER, Cardoso WV. Unravelling the expanding role of FGF10 signalling in lung homeostasis and maintenance. Eur Respir J. 2023 Nov; 62(5). PMID: 37945046.
Read at: PubMed - Published on 5/1/2023
Liu H, Li H, Jiang Z, Jin S, Song R, Yang Y, Li J, Huang J, Zhang X, Dong X, Mori M, Fritzler MJ, He L, Cardoso WV, Lu J. A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 01; 13(1):7090. PMID: 37127654.
Read at: PubMed - Published on 9/30/2022
Zhou Y, Yang Y, Guo L, Qian J, Ge J, Sinner D, Ding H, Califano A, Cardoso WV. Airway basal cells show regionally distinct potential to undergo metaplastic differentiation. Elife. 2022 Sep 30; 11. PMID: 36178196.
Read at: PubMed - Published on 9/21/2022
Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 Sep 21; 11. PMID: 36129169.
Read at: PubMed
View 101 more publications: View full profile at BUMC