Wellington V. Cardoso, MD, PhD

Adjunct Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research focuses on the molecular regulation of progenitor cell fate and morphogenesis in the developing lung and the contribution of developmental signals in lung regeneration and repair mechanisms. Over more than a decade my laboratory investigates the role of developmental pathways, including retinoic acid, Fgfs and Notch, in the establishment of cell fate and patterning of the embryonic lung. These studies have provided insights into specific gene regulatory networks that control induction of the lung primordium, airway branching and differentiation. Currently I direct a Program in Lung Developmental Biology at the Pulmonary Center BUSM, which congregates investigators with knowledge in lung morphogenesis, stem cell biology and regenerative medicine. The overall goals of this Program are to elucidate the properties and fates of lung progenitor cells, to develop tools for their characterization, and to understand the genetic and epigenetic mechanisms that control lineage as the lung forms. Interactions with this group have led to exciting collaborations and exchange of ideas and technologies.

Publications

  • Published 2/1/2025

    Makrides N, Sun E, Mir H, Jiang Z, Wu Y, Serra C, Cardoso WV, Shah NH, Zhang X. Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2. bioRxiv. 2025 Feb 01. PMID: 39974929.

    Read at: PubMed

  • Published 12/11/2024

    Ke X, van Soldt B, Vlahos L, Zhou Y, Qian J, George J, Capdevila C, Glass I, Yan K, Califano A, Cardoso WV. Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate. Dev Cell. 2025 Mar 24; 60(6):819-836.e7. PMID: 39667932.

    Read at: PubMed

  • Published 10/14/2024

    Dirvin B, Noh H, Tomassoni L, Cao D, Zhou Y, Ke X, Qian J, Schotsaert M, García-Sastre A, Karan C, Califano A, Cardoso WV. Identification and Targeting of Regulators of SARS-CoV-2-Host interactions in the Airway Epithelium. bioRxiv. 2024 Oct 14. PMID: 39464067.

    Read at: PubMed

  • Published 7/15/2024

    Mori M, Cardoso WV. Can a Rat Breathe through a Mouse's Lung? Am J Respir Crit Care Med. 2024 Jul 15; 210(2):133-134. PMID: 38701370.

    Read at: PubMed

  • Published 7/1/2024

    Hannan A, Wang Q, Wu Y, Makrides N, Qu X, Mao J, Que J, Cardoso W, Zhang X. Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion. bioRxiv. 2024 Jul 01. PMID: 39005335.

    Read at: PubMed

View All 111 Publications:   View Full Profile in BUMC

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Professor, Pathology & Laboratory Medicine
    Boston University Chobanian & Avedisian School of Medicine

Websites

Education

  • Universidade de Brasília, MD
  • Universidade de São Paulo, PhD

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