Weiwei Lin, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My research aims to use the power of precision mass spectrometry towards functional multi-omics-based systems biology to uncover the molecular networks altered in Alzheimer’s disease and other brain pathologies.
A) Mapping protein-protein interactions linked to AD progression and other neurodegenerative diseases.
B) High-resolution LC-MS-based integrative metabolomic and proteomic platform development and application.
C) Brain disease-associated native protein complexes.

Publications

  • Published 1/31/2026

    Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA. Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. bioRxiv. 2026 Jan 31. PMID: 41659520.

    Read at: PubMed

  • Published 11/1/2025

    Guangxin Sun,1† WeiWei Lin,2†, Ruixi Chen,1 Lulu Jiang, 3 Michael J. DeMott,1 Abigail McShane,1 Chi Kong Chan,1 Dylan Ehrbar,4 Xiaoling Zhang,5 Thomas J. Begley,4 Andrew Emili,6 Benjamin Wolozin,3* Peter C. Dedon1,. Distinct age- and pathology-dependent epitranscriptome and translational dysfunction in a tauopathy mouse model. BioRxiv. 2025.

    Read at: Custom

  • Published 7/6/2025

    Lin W, Phanse S, van der Spek SJF, Lampl N, Stephens MC, Ortiz AR, Taylor A, Hekman R, Roberts R, Jiang L, Havugimana P, Botas J, Emili A, Wolozin B. Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy. bioRxiv. 2025 Jul 06. PMID: 40631216.

    Read at: PubMed

  • Published 4/5/2025

    Lin W, Mousavi F, Blum BC, Heckendorf CF, Lawton M, Lampl N, Hekman R, McComb M, Emili A. Protocol for dual metabolomics and proteomics using nanoflow liquid chromatography-tandem mass spectrometry. STAR Protoc. 2025 Jun 20; 6(2):103745. PMID: 40188434.

    Read at: PubMed

  • Published 12/17/2024

    Lawton ML, Inge MM, Blum BC, Smith-Mahoney EL, Bolzan D, Lin W, McConney C, Porter J, Moore J, Youssef A, Tharani Y, Varelas X, Denis GV, Wong WW, Padhorny D, Kozakov D, Siggers T, Wuchty S, Snyder-Cappione J, Emili A. Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming. PLoS Biol. 2024 Dec; 22(12):e3002943. PMID: 39689157.

    Read at: PubMed

View All 25 Publications:   View Full Profile in BUMC

Websites

Education

  • Peking University, PhD
  • Guangzhou Medical College, MMed
  • Guangdong Medical & Pharmaceutical, BS

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