Shawn Lyons, PhD

Assistant Professor, Biochemistry & Cell Biology

Shawn Lyons
617.358.4280
smlyons1@bu.edu
View full profile at BUMC

Biography

Shawn Lyons obtained his Ph.D. in the laboratory of Dr. William Marzluff at UNC working on histone mRNA metabolism. He was a postdoctoral fellow with Dr. Paul Anderson at Harvard Medical School (Brigham and Women’s) and worked on the regulation of protein synthesis during acute stress response in cells, in particular how RNA metabolism and ribosome biogenesis are altered in response to stress.

Websites

Education

  • University of North Carolina at Chapel Hill, PhD
  • New York University, MS
  • University of North Carolina at Chapel Hill, BS

Publications

  • Published on 12/1/2024

    Kharel P, Bhatter N, Zubair S, Lyons S, Anderson PJ, Ivanov P. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides. bioRxiv. 2024 Dec 01. PMID: 39651178.

    Read at: PubMed
  • Published on 9/4/2024

    Bhatter N, Advani VM, Takenaka Y, Lyons SM, Akiyama Y, Anderson PJ, Ivanov P. Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavage. bioRxiv. 2024 Sep 04. PMID: 39282440.

    Read at: PubMed
  • Published on 8/6/2024

    Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA. Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Res. 2024 Oct; 230:105976. PMID: 39117283.

    Read at: PubMed
  • Published on 7/31/2024

    Gao Y, Kwan J, Orofino J, Burrone G, Mitra S, Fan TY, English J, Hekman R, Emili A, Lyons SM, Cardamone MD, Perissi V. Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation. Pharmacol Res. 2024 Sep; 207:107336. PMID: 39094987.

    Read at: PubMed
  • Published on 6/15/2024

    Lesniczak-Staszak M, Pietras P, Rucinski M, Johnston R, Sowinski M, Andrzejewska M, Nowicki M, Gowin E, Lyons SM, Ivanov P, Szaflarski W. Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention. J Cell Sci. 2024 Jun 15; 137(12). PMID: 38940347.

    Read at: PubMed
  • Published on 11/13/2023

    Nelson EV, Ross SJ, Olejnik J, Hume AJ, Deeney DJ, King E, Grimins AO, Lyons SM, Cifuentes D, Mühlberger E. The 3' Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay. J Infect Dis. 2023 Nov 13; 228(Supplement_7):S488-S497. PMID: 37551415.

    Read at: PubMed
  • Published on 9/20/2023

    Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Am J Hum Genet. 2023 Oct 05; 110(10):1735-1749. PMID: 37734371.

    Read at: PubMed
  • Published on 5/26/2023

    Reiss M, Keegan J, Aldrich A, Lyons SM, Flynn RL. The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA. FEBS Lett. 2023 Jul; 597(14):1818-1836. PMID: 37191774.

    Read at: PubMed
  • Published on 4/6/2023

    Paget M, Cadena C, Ahmad S, Wang HT, Jordan TX, Kim E, Koo B, Lyons SM, Ivanov P, tenOever B, Mu X, Hur S. Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA. Mol Cell. 2023 Apr 06; 83(7):1180-1196.e8. PMID: 37028415.

    Read at: PubMed
  • Published on 3/1/2022

    Akiyama Y, Lyons SM, Fay MM, Tomioka Y, Abe T, Anderson PJ, Ivanov P. Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. Front Mol Biosci. 2022; 9:791094. PMID: 35300117.

    Read at: PubMed

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