Nicole H. Siegel, MD

Clinical Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Nicole Siegel, MD, an Assistant Professor of Ophthalmology at the Chobanian and Avedisian School of Medicine, is the Vice Chair of Education and the Program Director of the Ophthalmology Residency. Formerly, she served as the Associate Program Director and the Director of Medical Student Education in the Department of Ophthalmology for the Chobanian and Avedisian School of Medicine. She is a vitreoretinal surgeon with her academic practice at Chobanian and Avedisian School of Medicine, as part of the Boston University Eye Associates (BUEA). She sees patients at Boston Medical Center and at the BUEA Brockton office. Dr. Siegel's clinical and surgical interests include diabetic retinopathy, age-related macular degeneration, retinal vein occlusions, intraocular inflammation, retinal detachments, macular holes and membranes, dislocated intraocular lenses.

Dr. Siegel completed both her Ophthalmology residency, serving as chief resident, and her two-year vitreoretinal Surgery fellowship at Boston Medical Center. Prior to that, Dr. Siegel graduated from the New York University School of Medicine. During her time in medical school she spent time doing research and was the vice president of the NYU chapter of Unite For Sight.

Dr. Siegel's research interests include evaluating patient satisfaction for sedation used in ophthalmic surgery, intraocular inflammation, the diagnostic yield of aqueous and vitreous biomarkers and on-going multi-disciplinary projects. In addition to invited oral presentations and authoring manuscripts, case reports and book chapters, Dr. Siegel is a member of the American Academy of Ophthalmology, the American Society of Retina Specialists, Women in Retina, The Association for Research in Vision and Ophthalmology, the Massachusetts Medical Society, and the New England Ophthalmological Society.

Publications

  • Published 6/5/2026

    Yarala R, Karnam S, Prasad M, Mittal R, Chen X, Ness S, Poulaki V, Siegel NH, Subramanian ML. Postoperative Outcomes in Combined Phacovitrectomy vs Vitrectomy Alone in Severe Diabetic Retinopathy. J Vitreoretin Dis. 2026 Jun 05; 24741264261451495. PMID: 42255508.

    Read at: PubMed

  • Published 5/30/2026

    Prasad M, Pulukuri S, Sampani K, Yarala R, Mittal R, Xia W, Stein TD, Aytan N, Chen X, Ness S, Siegel NH, Subramanian ML. Association of plasma glial fibrillary acidic protein and neurofilament light chain with retinal cell layer thickness: A cross-sectional study of ophthalmic surgical patients. J Alzheimers Dis. 2026 May 30; 13872877261452676. PMID: 42216665.

    Read at: PubMed

  • Published 3/17/2026

    Davoudi S, Islam Y, Ebrahimiadib N, Roohipourmoallai R, Grieser E, Poulaki V, Chen X, Beal CJ, Siegel NH, Subramanian ML, Tuli SS, Ness S. Association of Low Vitamin D with Infectious and Non-Infectious Inflammatory Ocular Disease. Ocul Immunol Inflamm. 2026 May; 34(4):731-736. PMID: 41843660.

    Read at: PubMed

  • Published 2/13/2026

    Khangura MS, Spratt MA, Gao A, Manhapra A, Siegel NH, Chen X, Poulaki V, Ness S, Stein T, Subramanian ML. The Association Between Diabetic Retinopathy Severity and Dementia Risk: A TriNetX Longitudinal Cohort Study. Am J Ophthalmol. 2026 May; 285:300-309. PMID: 41692179.

    Read at: PubMed

  • Published 9/22/2025

    Subramanian ML, Sampani K, Ness S, Tuz-Zahra F, Alluri S, Chen X, Siegel NH, Aytan N, Xia W, Tripodis Y, Alosco ML, Stein TD. Biomarkers for Alzheimer's disease are upregulated in patients with diabetic retinopathy. J Alzheimers Dis. 2025 Nov; 108(2):586-596. PMID: 40982223.

    Read at: PubMed

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Websites

Education

  • New York University School of Medicine, MD
  • Dartmouth College, BA

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