Kostas Alysandratos, MD, PHD

Assistant Professor, Medicine

Kostas Alysandratos
670 Albany Street


Dr. Konstantinos D. Alysandratos, MD, PhD is an Assistant Professor in the Department of Medicine at Chobanian and Avedisian School of Medicine and is part of the team at the Center for Regenerative Medicine at Boston University as part of Dr. Darrell N. Kotton’s lab. He received his Doctorate of Medicine from the University of Athens and embarked on his research journey after winning a competitive 3-year scholarship from the Hellenic State Scholarships Foundation. As part of his doctoral work under the mentorship of Dr. Theoharides at Tufts University, he studied the interplay between neuropeptides and cytokines in the pathogenesis of atopic dermatitis and their role on mast cell activation. He has also contributed to translational discoveries relating to mast cell activation in neurodevelopmental disorders such as autism spectrum disorders that may inform novel therapeutic approaches. Dr. Alysandratos completed his internal medicine training at UT Southwestern Medical Center, during which time he developed his passion for intensive and pulmonary care.

Other Positions

  • Member, Pulmonary Center, Boston University
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • University of Athens, MD
  • University of Athens, PhD


  • Published on 4/12/2018

    McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595. PMID: 29657097.

    Read at: PubMed
  • Published on 9/25/2017

    Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893. PMID: 28947536.

    Read at: PubMed
  • Published on 1/1/2017

    Alysandratos KD, Serra M, Mulugeta S, Beers MF, Kotton DN. Am J Respi Crit Care Med. Deriving alveolar type 2 cells from pluripotent stem cells to model surfactant protein C (SP-C) mutations in vitro. 2017; 195:A4317.

  • Published on 11/2/2015

    Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. PMID: 26525562.

    Read at: PubMed
  • Published on 9/1/2013

    Vasiadi M, Mondolfi AP, Alysandratos KD, Therianou A, Katsarou-Katsari A, Petrakopoulou T, Theoharidis A, Miniati A, Theoharides TC. Neurotensin serum levels and skin gene expression are increased in atopic dermatitis. Br J Dermatol. 2013 Sep; 169(3):695-9. PMID: 24033157.

    Read at: PubMed
  • Published on 1/1/2011

    Asadi S, Zhang B, Alysandratos KD, Angelidou A, Vasiadi M, Theoharides TC. J Allergy Clin Immunol. Substance P (SP) induces expression of functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in human mast cells. 2011; 127(2 suppl):AB162.

  • Published on 1/1/2011

    Theoharides TC, Angelidou A, Alysandratos KD, Asadi S, Francis K, Lykouras L, Kalogeromitros D. Autism- A Neurodevelopmental Journey from Genes to Behaviour (Eapen V, Ed.). Perinatal immune activation and risk of autism. Intech Open Access Publisher. Rijeka, Croatia. 2011; 267-88.

  • Published on 12/28/2010

    Theoharides TC, Angelidou A, Alysandratos KD, Zhang B, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2012 Jan; 1822(1):34-41. PMID: 21193035.

    Read at: PubMed
  • Published on 1/1/2010

    Theoharides TC, Alysandratos KD, Angelidou A, Zhang BD. The Tumor Microenvironment (Bagley RG, Ed.). Mast cells and tumor microenvironment. Humana Press. New York. 2010; 353-70.

  • Published on 1/1/2010

    Zhang BD, Angelidou A, Alysandratos KD, Tagen M, Kempuraj D, Asadi S, Theoharides TC. FASEB J. Human mast cell degranulation is distinguished from selective secretion of TNF through intracellular calcium, energy and mitochondrial morphology dynamics. 2010; 24:996.3.

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