Joseph P. Mizgerd, ScD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.

Publications

  • Published 3/25/2025

    Vasquez JH, Yuan J, Leow CJ, Crossey E, Shao F, Carty S, Dominguez VA, Lo M, Mizgerd JP, Fetterman JL, Lau NC, Fine A, Jones MR. Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis. iScience. 2025 Apr 18; 28(4):112291. PMID: 40241756.

    Read at: PubMed

  • Published 3/4/2025

    Traber KE, Mizgerd JP. The Integrated Pulmonary Immune Response to Pneumonia. Annu Rev Immunol. 2025 Apr; 43(1):545-569. PMID: 40036700.

    Read at: PubMed

  • Published 2/25/2025

    Soucy AM, Brune JE, Jayaraman A, Shenoy AT, Korkmaz FT, Etesami NS, Hiller BE, Martin IM, Goltry WN, Ha CT, Crossland NA, Campbell JD, Beach TG, Traber KE, Jones MR, Quinton LJ, Bosmann M, Frevert CW, Mizgerd JP. Transcriptomic responses of lung mesenchymal cells during pneumonia. JCI Insight. 2025 Feb 25; 10(7). PMID: 39998887.

    Read at: PubMed

  • Published 2/17/2025

    Ravi VR, Korkmaz FT, De Ana CL, Lu L, Shao FZ, Odom CV, Barker KA, Ramanujan A, Niszczak EN, Goltry WN, Martin IMC, Ha CT, Quinton LJ, Jones MR, Fine A, Welch JD, Chen F, Belkina AC, Mizgerd JP, Shenoy AT. Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease. Cell Rep. 2025 Mar 25; 44(3):115294. PMID: 39965565.

    Read at: PubMed

  • Published 1/9/2025

    Harlow OS, Ravi VR, Ke F, Sanders NL, Armstrong E, Mizgerd JP, Shenoy AT. The mysterious case of missing lymphocytes: a cautionary tale of interinstitutional variability in outcomes of lung dissociation protocols. Am J Physiol Lung Cell Mol Physiol. 2025 Feb 01; 328(2):L260-L266. PMID: 39786964.

    Read at: PubMed

View All 153 Publications:   View Full Profile in BUMC

Other Positions

  • Director, Pulmonary Center
    Boston University Chobanian & Avedisian School of Medicine
  • Professor, Biochemistry & Cell Biology
    Boston University Chobanian & Avedisian School of Medicine
  • Professor, Virology, Immunology & Microbiology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Harvard School of Public Health, ScD
  • Amherst College, BA

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