Jean-Pierre Roussarie

Assistant Professor, Anatomy & Neurobiology

Jean-Pierre Roussarie
617.358.2200
72 E. Concord St

Biography

The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.

Websites

Classes Taught

  • AN777

Publications

  • Published on 3/11/2024

    Rodriguez-Rodriguez P, Arroyo-Garcia LE, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC, Troyanskaya O, Flajolet M, Yao V, Roussarie JP. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain. 2024 Mar 11. PMID: 38462574.

    Read at: PubMed
  • Published on 8/12/2023

    Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2024 May 15; 95(10):926-937. PMID: 37579933.

    Read at: PubMed
  • Published on 3/9/2023

    Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Herv D, Gambardella N, Roussarie JP, Girault JA. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. bioRxiv. 2023 Mar 09. PMID: 36945487.

    Read at: PubMed
  • Published on 3/9/2023

    Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Herv D, Gambardella N, Roussarie JP, Girault JA. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. bioRxiv. 2023 Mar 09. PMID: 36945487.

    Read at: PubMed
  • Published on 12/1/2022

    Marion-Poll L, Roussarie JP, Taing L, Dard-Dascot C, Servant N, Jaszczyszyn Y, Jordi E, Mulugeta E, Hervé D, Bourc'his D, Greengard P, Thermes C, Girault JA. DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons. Commun Biol. 2022 Dec 01; 5(1):1321. PMID: 36456703.

    Read at: PubMed
  • Published on 2/18/2022

    Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, Luquet S, Nairn AC, Hervé D, Heintz N, Martin C, Greengard P, Valjent E, Meye FJ, Gambardella N, Roussarie JP, Girault JA. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol Psychiatry. 2022 Apr; 27(4):2068-2079. PMID: 35177825.

    Read at: PubMed
  • Published on 10/19/2020

    Roussarie JP, Rodriguez-Rodriguez P. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Adv Pharmacol. 2021; 90:145-171. PMID: 33706931.

    Read at: PubMed
  • Published on 6/29/2020

    Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 09 09; 107(5):821-835.e12. PMID: 32603655.

    Read at: PubMed
  • Published on 7/27/2015

    Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015 Sep; 18(9):1325-33. PMID: 26214373.

    Read at: PubMed
  • Published on 1/1/2015

    Vidalain PO, Jacob Y, Hagemeijer MC, Jones LM, Neveu G, Roussarie JP, Rottier PJ, Tangy F, de Haan CA. A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions. Methods Mol Biol. 2015; 1282:213-29. PMID: 25720483.

    Read at: PubMed

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