Jean-Pierre Roussarie

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.

Publications

  • Published 3/16/2026

    Tsagkogianni C, Trivisonno M, Willner JS, Garcia-Molinero C, Tang Y, Mattina B, Latorre-Leal M, Wang W, Roussarie JP, Rodriguez-Rodriguez P. Optineurin is a gatekeeper of mitochondrial health and proteostasis in Alzheimer's disease vulnerable neurons. bioRxiv. 2026 Mar 16. PMID: 41889952.

    Read at: PubMed

  • Published 2/3/2026

    Oh SJ, Jang JH, Roussarie JP, Jang GU, Jeong MS, Jo YS, Shin CH, Choi H, Lee K, Yoon JH, Oh YS. Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy. Mol Psychiatry. 2026 Jun; 31(6):3385-3398. PMID: 41634134.

    Read at: PubMed

  • Published 10/1/2025

    Lai Q, Dannenfelser R, Roussarie JP, Yao V. Disentangling associations between complex traits and cell types with seismic. Nat Commun. 2025 Oct 01; 16(1):8744. PMID: 41034207.

    Read at: PubMed

  • Published 1/29/2025

    Rodriguez-Rodriguez P, Wang W, Tsagkogianni C, Feng I, Morello-Megias A, Jain K, Alanko V, Kahvecioglu HA, Mohammadi E, Li X, Flajolet M, Sandebring-Matton A, Maioli S, Vidal N, Milosevic A, Roussarie JP. Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology. bioRxiv. 2025 Jan 29. PMID: 39803521.

    Read at: PubMed

  • Published 12/30/2024

    Zhang R, Rodriguez-Rodriguez P, Medrihan L, Chang JC, Ferraro T, Del Cioppo Vasques P, Wang W, Menard C, Cathomas F, Chan KL, Parise L, Shaham S, Roussarie JP, Troyanskaya O, Russo SJ, Milosevic A. Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression. bioRxiv. 2024 Dec 30. PMID: 39803419.

    Read at: PubMed

View All 19 Publications:   View Full Profile in BUMC

Websites

Education

  • Pierre and Marie Curie University (Paris VI), PhD
  • Pierre and Marie Curie University (Paris VI), MS
  • École Polytechnique, BA

View all profiles