Jean-Pierre Roussarie
Assistant Professor, Anatomy & Neurobiology
Biography
The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.
Websites
Classes Taught
Publications
- Published on 1/29/2025
Rodriguez-Rodriguez P, Wang W, Tsagkogianni C, Feng I, Morello-Megias A, Jain K, Alanko V, Kahvecioglu HA, Mohammadi E, Li X, Flajolet M, Sandebring-Matton A, Maioli S, Vidal N, Milosevic A, Roussarie JP. Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology. bioRxiv. 2025 Jan 29. PMID: 39803521.
Read at: PubMed - Published on 12/30/2024
Zhang R, Rodriguez-Rodriguez P, Medrihan L, Chang JC, Ferraro T, Del Cioppo Vasques P, Wang W, Menard C, Cathomas F, Chan KL, Parise L, Shaham S, Roussarie JP, Troyanskaya O, Russo SJ, Milosevic A. Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression. bioRxiv. 2024 Dec 30. PMID: 39803419.
Read at: PubMed - Published on 7/5/2024
Rodriguez-Rodriguez P, Arroyo-Garcia LE, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC, Troyanskaya O, Flajolet M, Yao V, Roussarie JP. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain. 2024 Jul 05; 147(7):2384-2399. PMID: 38462574.
Read at: PubMed - Published on 5/7/2024
Lai Q, Dannenfelser R, Roussarie JP, Yao V. Disentangling associations between complex traits and cell types with seismic. bioRxiv. 2024 May 07. PMID: 38765980.
Read at: PubMed - Published on 8/12/2023
Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2024 May 15; 95(10):926-937. PMID: 37579933.
Read at: PubMed - Published on 12/1/2022
Marion-Poll L, Roussarie JP, Taing L, Dard-Dascot C, Servant N, Jaszczyszyn Y, Jordi E, Mulugeta E, Hervé D, Bourc'his D, Greengard P, Thermes C, Girault JA. DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons. Commun Biol. 2022 Dec 01; 5(1):1321. PMID: 36456703.
Read at: PubMed - Published on 2/18/2022
Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, Luquet S, Nairn AC, Hervé D, Heintz N, Martin C, Greengard P, Valjent E, Meye FJ, Gambardella N, Roussarie JP, Girault JA. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol Psychiatry. 2022 Apr; 27(4):2068-2079. PMID: 35177825.
Read at: PubMed - Published on 10/19/2020
Roussarie JP, Rodriguez-Rodriguez P. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Adv Pharmacol. 2021; 90:145-171. PMID: 33706931.
Read at: PubMed - Published on 6/29/2020
Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 09 09; 107(5):821-835.e12. PMID: 32603655.
Read at: PubMed - Published on 7/27/2015
Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015 Sep; 18(9):1325-33. PMID: 26214373.
Read at: PubMed
View 5 more publications: View full profile at BUMC