Jean-Jacques Soghomonian, PhD

Emeritus Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson's disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

Publications

  • Published 1/11/2024

    Soghomonian JJ. The cortico-striatal circuitry in autism-spectrum disorders: a balancing act. Front Cell Neurosci. 2023; 17:1329095. PMID: 38273975.

    Read at: PubMed

  • Published 11/9/2020

    Brandenburg C, Soghomonian JJ, Zhang K, Sulkaj I, Randolph B, Kachadoorian M, Blatt GJ. Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry. Front Cell Neurosci. 2020; 14:577858. PMID: 33240045.

    Read at: PubMed

  • Published 7/21/2017

    Subramanian K, Brandenburg C, Orsati F, Soghomonian JJ, Hussman JP, Blatt GJ. Basal ganglia and autism - a translational perspective. Autism Res. 2017 Nov; 10(11):1751-1775. PMID: 28730641.

    Read at: PubMed

  • Published 7/14/2017

    Soghomonian JJ, Zhang K, Reprakash S, Blatt GJ. Decreased parvalbumin mRNA levels in cerebellar Purkinje cells in autism. Autism Res. 2017 Nov; 10(11):1787-1796. PMID: 28707805.

    Read at: PubMed

  • Published 7/15/2015

    Zhang K, Chammas C, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10; 303:586-94. PMID: 26188284.

    Read at: PubMed

View All 60 Publications:   View Full Profile in BUMC

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Université de Montréal, PhD
  • Aix-Marseille Université, MSc

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