Ivana Delalle, MD, PhD
Professor, Pathology & Laboratory Medicine
Biography
Ivana Delalle is a Professor of Pathology and Laboratory Medicine and Professor of Neurology at Boston University (BU) Chobanian and Avedisian School of Medicine and a Neuropathologist at the Department of Pathology and Laboratory Medicine at Boston Medical Center. Dr. Delalle conducts research bridging basic and clinical science to advance the understanding of the pathogenesis of neurodegenerative diseases. Her present focus, supported by the by National Institutes of Health (NIH) / National Institute of Aging (NIA) is on novel, early, and reliable biomarkers of Alzheimer’s Disease.
Dr. Delalle attended the Zagreb University School of Medicine, Zagreb, Croatia, where she received her MD in 1988 and, in 1992, her PhD in the Developmental Neuroanatomy Laboratory headed by Professor Ivica Kostovic, a pioneer in the understanding of transient layers in the developing human cortex. Dr. Delalle subsequently joined Developmental Neurobiology Laboratory headed by Professor Verne Caviness at Massachusetts General Hospital (MGH) in Boston where she elucidated the expression of cell cycle regulators in relation to the cortical development. After completing her Research Fellowship in Neurology at Harvard Medical School in 1997, Dr. Delalle pursued further postgraduate training as a resident in Anatomic Pathology and Neuropathology in the Department of Pathology at MGH. She became board certified by the American Board of Pathology in Anatomic Pathology and Neuropathology in 2001. Dr. Delalle worked in the teaching hospitals of Harvard Medical School and BU Chobanian and Avedisian School of Medicine as a scientist investigating neurodegenerative and neuropsychiatric diseases, as a neuropathologist with expertise in neurooncology in the clinical arena, and as a teacher and mentor committed to the education of medical students, residents, and neuropathology fellows. Dr. Delalle was the Director of Neuropathology Service at Rhode Island Hospital (2019 -2023) and a Professor of Pathology at Warren Alpert Medical School of Brown University (2020-2023).
Other Positions
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
Education
- University of Zagreb, MD
- University of Zagreb, PhD
Publications
- Published on 1/27/2025
Fischer A, Nho K, Saykin AJ, Delalle I. Response to the Letter, "Circulating small RNAs shed light on dementia risk," by Anthony S. Zannas. Alzheimers Dement. 2025 Feb; 21(2):e14404. PMID: 39868847.
Read at: PubMed - Published on 9/18/2024
Liu S, Park T, Krüger DM, Pena-Centeno T, Burkhardt S, Schutz AL, Huang YN, Rosewood T, Chaudhuri S, Cho M, Risacher SL, Wan Y, Shaw LM, Sananbenesi F, Brodsky AS, Lin H, Krunic A, Blusztajn JK, Saykin AJ, Delalle I, Fischer A, Nho K. Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers. Alzheimers Dement. 2024 Nov; 20(11):7698-7714. PMID: 39291737.
Read at: PubMed - Published on 9/18/2024
Krüger DM, Pena-Centeno T, Liu S, Park T, Kaurani L, Pradhan R, Huang YN, Risacher SL, Burkhardt S, Schütz AL, Wan Y, Shaw LM, Brodsky AS, DeStefano AL, Lin H, Schroeder R, Krunic A, Hempel N, Sananbenesi F, Blusztajn JK, Saykin AJ, Delalle I, Nho K, Fischer A. The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals. Alzheimers Dement. 2024 Nov; 20(11):7479-7494. PMID: 39291752.
Read at: PubMed - Published on 8/29/2024
Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A. PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease. Acta Neuropathol. 2024 Aug 29; 148(1):32. PMID: 39207536.
Read at: PubMed - Published on 7/1/2024
Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A. PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer's Disease. bioRxiv. 2024 Jul 01. PMID: 39005272.
Read at: PubMed - Published on 3/25/2024
Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel A, Schulze TG, Falkai P, Sananbenesi F, Fischer A. Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. EMBO J. 2024 Apr; 43(8):1420-1444. PMID: 38528182.
Read at: PubMed - Published on 2/26/2024
Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45. PMID: 38407651.
Read at: PubMed - Published on 2/22/2023
Castro-Hernández R, Berulava T, Metelova M, Epple R, Peña Centeno T, Richter J, Kaurani L, Pradhan R, Sakib MS, Burkhardt S, Ninov M, Bohnsack KE, Bohnsack MT, Delalle I, Fischer A. Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proc Natl Acad Sci U S A. 2023 Feb 28; 120(9):e2204933120. PMID: 36812208.
Read at: PubMed - Published on 11/16/2022
Tubre T, Hacking S, Alexander A, Brickman A, Delalle I, Elinzano H, Donahue JE. Prostate-Specific Membrane Antigen Expression in Meningioma: A Promising Theranostic Target. J Neuropathol Exp Neurol. 2022 Nov 16; 81(12):1008-1017. PMID: 36179256.
Read at: PubMed - Published on 10/27/2022
Oraki Kohshour M, Papiol S, Delalle I, Rossner MJ, Schulze TG. Extracellular vesicle approach to major psychiatric disorders. Eur Arch Psychiatry Clin Neurosci. 2023 Sep; 273(6):1279-1293. PMID: 36302978.
Read at: PubMed
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