Haiyan Gong, MD, PhD
Professor, Ophthalmology
Biography
Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.
Other Positions
- Professor, Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Nanchang University, MD
- Boston University School of Medicine, PhD
- Peking Union Medical College, MS
Publications
- Published on 12/2/2024
Acott TS, Fautsch MP, Mao W, Ethier CR, Huang AS, Kelley MJ, Aga M, Bhattacharya SK, Borras T, Bovenkamp D, Chowdhury UR, Clark AF, Dibas MI, Du Y, Elliott MH, Faralli JA, Gong H, Herberg S, Johnstone MA, Kaufman PL, Keller KE, Kelly RA, Krizaj D, Kuehn MH, Li HL, Lieberman R, Lin SC, Liu Y, McDonnell FS, McDowell CM, McLellan GJ, Mzyk P, Nair KS, Overby DR, Peters DM, Raghunathan V, Rao PV, Roddy GW, Sharif NA, Shim MS, Sun Y, Thomson BR, Toris CB, Willoughby CE, Zhang HF, Freddo TF, Fuchshofer R, Hill KR, Karimi A, Kizhatil K, Kopcyznski CC, Liton P, Patel G, Peng M, Pattabiraman PP, Prasanna G, Reina-Torres E, Samples EG, Samples JR, Steel CL, Strohmaier CA, Subramanian P, Sugali CK, van Batenburg-Sherwood J, Wong C, Youngblood H, Zode GS, White E, Stamer WD. Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Invest Ophthalmol Vis Sci. 2024 Dec 02; 65(14):32. PMID: 39693082.
Read at: PubMed - Published on 11/29/2024
Karimi A, Razaghi R, Stanik A, Daniel D'costa S, Mirafzal I, Kelley MJ, Acott TS, Gong H. High-resolution modeling of aqueous humor dynamics in the conventional outflow pathway of a normal human donor eye. Comput Methods Programs Biomed. 2025 Mar; 260:108538. PMID: 39644783.
Read at: PubMed - Published on 10/1/2024
Chung YG, Fan S, Gulati V, Li HL, Gong H, Toris CB, Prausnitz MR, Ethier CR. IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space. Transl Vis Sci Technol. 2024 Oct 01; 13(10):14. PMID: 39377753.
Read at: PubMed - Published on 4/17/2024
Karimi A, Aga M, Khan T, D'costa SD, Thaware O, White E, Kelley MJ, Gong H, Acott TS. Comparative analysis of traction forces in normal and glaucomatous trabecular meshwork cells within a 3D, active fluid-structure interaction culture environment. Acta Biomater. 2024 May; 180:206-229. PMID: 38641184.
Read at: PubMed - Published on 12/1/2023
Li HL, Ren R, Gong H. Segmental Unconventional Outflow in Mouse Eyes. Invest Ophthalmol Vis Sci. 2023 Dec 01; 64(15):26. PMID: 38117243.
Read at: PubMed - Published on 11/22/2023
Dixon A, Shim MS, Nettesheim A, Coyne A, Su CC, Gong H, Liton PB. Autophagy deficiency protects against ocular hypertension and glaucoma. Autophagy Rep. 2024; 3(1). PMID: 39726939.
Read at: PubMed - Published on 10/31/2023
Karimi A, Razaghi R, D'costa SD, Torbati S, Ebrahimi S, Rahmati SM, Kelley MJ, Acott TS, Gong H. Implementing new computational methods for the study of JCT and SC inner wall basement membrane biomechanics and hydrodynamics. Comput Methods Programs Biomed. 2024 Jan; 243:107909. PMID: 37976613.
Read at: PubMed - Published on 9/4/2023
Karimi A, Razaghi R, Kelley MJ, Acott TS, Gong H. Biomechanics of the JCT and SC Inner Wall Endothelial Cells with Their Basement Membrane Using 3D Serial Block-Face Scanning Electron Microscopy. Bioengineering (Basel). 2023 Sep 04; 10(9). PMID: 37760140.
Read at: PubMed - Published on 8/24/2023
Dixon A, Shim MS, Nettesheim A, Coyne A, Su CC, Gong H, Liton PB. Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontanous glaucoma mouse models. Cell Death Dis. 2023 Aug 24; 14(8):554. PMID: 37620383.
Read at: PubMed - Published on 2/1/2023
Ren R, Humphrey AA, Kopczynski C, Gong H. Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes. Invest Ophthalmol Vis Sci. 2023 Feb 01; 64(2):7. PMID: 36734964.
Read at: PubMed
View 82 more publications: View full profile at BUMC