Haiyan Gong, MD, PhD
ASSOCIATE PROFESSOR OF OPHTHALMOLOGY AND ANATOMY AND NEUROBIOLOGY
M.D.: Jiangxi Medical College
M.S.: Peking Union Medical College
Ph.D.: Boston University
The broad goal of our research is to determine the principal site of aqueous humor outflow resistance in the normal human eye and to determine how this resistance is increased in primary open-angle glaucoma. Currently there are four ongoing research projects:
1. A potential target site to decrease outflow resistance (Funded by the American Health Assistance Foundation)
Major goals of this project is to better understand how the connectivity between the inner wall of Schlemm’s canal and underlying juxtacanalicular connective tissue (JCT) plays a role in regulation of outflow resistance and its potential mechanism in non-human and human eyes and to determine whether the inner wall and JCT separation can be induced in human eyes to decrease outflow resistance.
2. A study of the dynamics of Schlemm’s canal endothelial cells using a three-dimensional cell culture device with real-time imaging (Funded by the Glaucoma Research Foundation)
Major goals of this project is to modify and apply a three-dimensional cell culture device with real-time imaging recently developed at MIT to study the dynamics of cultured Schlemm’s canal endothelial cells from normal and POAG eyes.
3. New strategies for the development of glaucoma treatment (Funded by Boston University School of Medicine Wing Tat Lee Fund)
Major goals of this project is to establish a collaborative research and training program between Boston University School of Medicine and Huashan Hospital of Fudan University, Shanghai, China
4. Outflow Area and its Role in Glaucoma Pathogenesis (Funded by the American Health Assistance Foundation and the Massachusetts Lions Eye Research Fund, Inc.)
Major goals of this project is to determine whether increased outflow resistance in glaucoma could be related to an irreversible herniation of the inner wall and JCT into collector channel ostia and a diminished capacity for these eyes to recruit additional areas for outflow, as IOP changes.
Zhang Y, Carol B Toris CB, Ye Liu, Ye W, Gong H: Morphological and Hydrodynamic Correlates in Monkey Eyes with Laser Induced-Glaucoma. Exp Eye Res, in press, 2009
Gong H and Freddo TF: The Washout Phenomenon in Aqueous Outflow – Why Does it Matter? Exp Eye Res, 88:729-737, 2009.
Battista SA, Lu Z, Hofmann S, Freddo TF, Overby DR, Gong H: Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes. Invest Ophthalmol Vis Sci, 49:5346-5352, 2008.
Sieminski AL, Semino CE, Gong H, Kamm RD: Primary sequence of ionic self-assembling peptide gels affects endothelial cell adhesion and capillary morphogenesis. J Biomed Mater Res A, 87(2):494-504, 2008.
Lu Z, Overby DR, Scott PA, Freddo TF, Gong H: The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res, 86:271-281, 2008.
Sieminski AL, Was AS, Kim G, Gong H, Semino CE, Kamm RD: The stiffness of three-dimensional ionic self-assembling peptide gels affects the extent of capillary-like network formation. Biophysical Properties of Synthetic Biomaterial Supports and Capillary Morphogenesis. Cell Biochem and Biophysics. 49:73-83, 2007.
DiMicco MA, Kisiday JD, Gong H, Grodzinsky AJ: Structure of pericellular matrix around agarose-embedded chondrocytes. Osteoarthritis Cartilage. 15(10):1207-1216, 2007.
Scott PA, Overby DR, Freddo TF, Gong H: Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res, 84:435-443, 2007.
Zaman MH, Trapani LM, Sieminski AL, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Prc Natl Acad Sci USA, 2006 Jul 18; 103(29):10889-10894. PMID 16832052.
Freddo TF, Civan M and Gong H: Aqueous humor and the dynamics of its flow: mechanisms and routes of aqueous humor drainage. In: Principles and Practice of Ophthalmology, 3rd edition. Albert DM and Jakobiec F, eds. Chapter 191, 2008.
Freddo TF and Gong H: Anatomy of the Ciliary Body and Outflow Pathways. In Duane’s Clinical Ophthalmology. Lippincott, Williams & Wilkins, 2002 edition.