Felicia Chen, MD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Chen's laboratory projects focus on retinoic acid biology in healthy and diseased lungs. She uses a multifaceted approach to knock down retinoic acid signals in mouse models for her studies, including dietary deprivation of vitamin A, pharmacologic blockade of retinoic acid synthesis and receptor activation, as well as genetic modifications. Her current projects include the regulatory properties of retinoic acid on 1) airway smooth muscle homeostasis, 2) lung microbiome, 3) embryonic airway epithelial specification, and 4) matrix fibroblast activation.

Special interests include:
-Vitamin A and retinoid biology
-Embryonic lung development
-Lung homeostasis
-Lung injury and repair
-Fibrotic lung diseases
-Asthma

Publications

  • Published 1/1/2020

    Marquez HA, Chen F. Retinoic Acid Signaling and Development of the Respiratory System. Subcell Biochem. 2020; 95:151-174. PMID: 32297299.

    Read at: PubMed

  • Published 5/13/2019

    Norman TA, Gower AC, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019; 14(5):e0216795. PMID: 31083674.

    Read at: PubMed

  • Published 8/23/2018

    Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16). PMID: 30135301.

    Read at: PubMed

  • Published 9/18/2017

    Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876. PMID: 28920925.

    Read at: PubMed

  • Published 8/11/2016

    Chen F, Fine A. Stem Cells in Lung Injury and Repair. Am J Pathol. 2016 Oct; 186(10):2544-50. PMID: 27524796.

    Read at: PubMed

View All 13 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Pulmonary Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Courtesy Staff Privileges, Medicine
    Boston Medical Center

Websites

Education

  • Albany Medical College, MD
  • Johns Hopkins University, BA

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