Esther Landesman, PhD

Instructor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Landesman's research has focused on studying the role of protein kinase CK2, a highly conserved and constitutively expressed serine-threonine kinase. In vitro and transgenic mouse models were used to study the role of CK2 in breast tumorigenesis and the synergism of CK2 with the absence of p53 in lymphoma development. Genetic disruption of the catalytic subunits of CK2: CK2a and CK2a’ have uncovered the impact of CK2 in mouse embryonic development. Current research attempts to characterize the consequences of compounded reduction of CK2 catalytic subunits in mice. Dr. Landesman-Bollag obtained her PhD and did her postdoctoral training at Chobanian and Avedisian School of Medicine in the laboratory of the late Dr. David Seldin. She is Instructor of Hematology & Medical Oncology at Chobanian and Avedisian School of Medicine.

Publications

  • Published 5/1/2021

    Zhou Y, Lian H, Shen N, Korm S, Kwok Ping Lam A, Layton O, Huiting LN, Li D, Miao K, Zeng A, Landesman-Bollag E, Seldin DC, Fu H, Hong L, Feng H. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021 05 01; 106(5):1461-1465. PMID: 32817283.

    Read at: PubMed

  • Published 10/6/2016

    Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica. 2017 01; 102(1):e17-e21. PMID: 27758824.

    Read at: PubMed

  • Published 8/29/2016

    Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Landesman E, Laklouk I, Sarita-Reyes C, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, Sherr DH. An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells. Mol Pharmacol. 2016 Nov; 90(5):674-688. PMID: 27573671.

    Read at: PubMed

  • Published 3/16/2016

    Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol. 2016 Mar 16; 14:20. PMID: 26984638.

    Read at: PubMed

  • Published 10/10/2012

    Romagnoli M, Belguise K, Yu Z, Wang X, Landesman-Bollag E, Seldin DC, Chalbos D, Barillé-Nion S, Jézéquel P, Seldin ML, Sonenshein GE. Epithelial-to-mesenchymal transition induced by TGF-ß1 is mediated by Blimp-1-dependent repression of BMP-5. Cancer Res. 2012 Dec 1; 72(23):6268-78. PMID: 23054396.

    Read at: PubMed

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Websites

Education

  • Boston University, PhD
  • The Hebrew University of Jerusalem, MS
  • The Hebrew University of Jerusalem, BS

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