Catherine E. Costello, PhD

William Fairfield Warren Distinguished Professor, Biochemistry & Cell Biology

Catherine Costello
670 Albany St Biosquare III


Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the Chobanian & Avedisian School of Medicine Biochemistry & Cell Biology Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 400 scientific papers, serves on a number of advisory boards and editorial boards of major journals, and has received numerous awards and honors, including the 2009 Thomson Medal from the International Mass Spectrometry Foundation (IMSF), the 2010 Field and Franklin Award from the American Chemical Society (ACS), and the 2017 Distinguished Contribution Award from the American Society for Mass Spectrometry (ASMS), the three highest honors in her field. She is a Fellow of the ACS and the American Association for the Advancement of Science. She has served as President of IMSF, ASMS, and the Human Proteome Organization.

Other Positions

  • Professor, Chemistry, Boston University Chobanian & Avedisian School of Medicine
  • Research Professor, Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine
  • Director, Center for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center, Boston University
  • Member, Amyloidosis Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


  • Georgetown University, PhD
  • Georgetown University, MS
  • Emmanuel College, AB

Classes Taught

  • GMSBI793


  • Published on 3/6/2024

    Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel). 2024 Mar 06; 13(1). PMID: 38534207.

    Read at: PubMed
  • Published on 1/11/2024

    Li R, Xia C, Wu S, Downs MJ, Tong H, Tursumamat N, Zaia J, Costello CE, Lin C, Wei J. Direct and Detailed Site-Specific Glycopeptide Characterization by Higher-Energy Electron-Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2024 Jan 23; 96(3):1251-1258. PMID: 38206681.

    Read at: PubMed
  • Published on 11/23/2023

    Rahimi N, White MR, Amraei R, Lotfollahzadeh S, Xia C, Michalak M, Costello CE, Mühlberger E. Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity. Cells. 2023 Nov 23; 12(23). PMID: 38067122.

    Read at: PubMed
  • Published on 10/25/2023

    Liyanage OT, Xia C, Ringler S, Stahl B, Costello CE. Defining the Ceramide Composition of Bovine and Human Milk Gangliosides by Direct Infusion ESI-CID Tandem Mass Spectrometry of Native and Permethylated Molecular Species. Anal Chem. 2023 Nov 14; 95(45):16465-16473. PMID: 37877731.

    Read at: PubMed
  • Published on 9/1/2023

    Kanjana K, Strle K, Lochhead RB, Pianta A, Mateyka LM, Wang Q, Arvikar SL, Kling DE, Deangelo CA, Curham L, Barbour AG, Costello CE, Moon JJ, Steere AC. Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis. J Clin Invest. 2023 Sep 01; 133(17). PMID: 37471146.

    Read at: PubMed
  • Published on 8/4/2023

    Zhang L, Liu X, Wang X, Zhu G, Song H, Cheng R, Naowarojna N, Costello CE, Liu P. Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1". Angew Chem Int Ed Engl. 2023 Sep 11; 62(37):e202218643. PMID: 37541669.

    Read at: PubMed
  • Published on 6/2/2023

    Wei J, Papanastasiou D, Kosmopoulou M, Smyrnakis A, Hong P, Tursumamat N, Klein JA, Xia C, Tang Y, Zaia J, Costello CE, Lin C. De novo glycan sequencing by electronic excitation dissociation MS2-guided MS3 analysis on an Omnitrap-Orbitrap hybrid instrument. Chem Sci. 2023 Jun 21; 14(24):6695-6704. PMID: 37350811.

    Read at: PubMed
  • Published on 5/26/2023

    Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror KV, Farmer SR, Wei W, Costello CE, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul; 73:101744. PMID: 37245847.

    Read at: PubMed
  • Published on 5/11/2023

    Sanes JT, Costello CE, Steere AC. Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2023 Jul; 75(7):1263-1274. PMID: 36716113.

    Read at: PubMed
  • Published on 4/19/2023

    van der Wel H, Garcia AM, Gas-Pascual E, Willis MM, Kim HW, Bandini G, Gaye MM, Costello CE, Samuelson J, West CM. Spindly is a nucleocytosolic O-fucosyltransferase in Dictyostelium and related proteins are widespread in protists and bacteria. Glycobiology. 2023 Apr 19; 33(3):225-244. PMID: 36250576.

    Read at: PubMed

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