• Title William Fairfield Warren Distinguished Professor
    Director, Center for Biomedical Mass Spectrometry
  • Education MS, PhD: Georgetown University, Washington, DC
  • Office 670 Albany, Room 511
  • Web Address http://www.bumc.bu.edu/msr/
  • Phone 617-638-6490
  • Area of Interest Biopolymer structural studies based on development and application of mass spectral methods

The objective of our research is to establish the detailed structures of biopolymers in order to understand their structure-activity relationships as they influence or reflect biological processes related to health, growth and development, and disease. Our particular focus for new method development is on the needs of glycobiology, since carbohydrates and their conjugates (glycoproteins, glycolipids, etc.) are involved in targeting and immune system recognition, nervous system growth and development, infection, parasite response, carcinogenesis, and other critical processes. The techniques for full structural characterization of these complex molecules are much less developed than are methods for linear biopolymers (proteins and oligonucleotides). Recent introduction of new mass spectral ionization methods and rapid progress in means for mass separation and detection now make it possible to perform structural studies on low picomole amounts of samples even when they are complex mixtures. In our research program we are refining and extending the tools of mass spectrometry and are applying them to studies of biopolymers undertaken with collaborators at BUSM and other institutions around and outside the US. Our laboratory is a Resource Center sponsored by the NIH National Institute of General Medical Sciences.


Cheng Lin – Research Associate Professor
Mark McComb – Research Associate Professor
Kevin Chandler – Postdoctoral Associate
Deborah Francoleon – Postdoctoral Associate
Christian Heckendorf – Postdoctoral Associate
Bo Yan – Postdoctoral Associate
John Haserick – Graduate Student

  1. Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O’Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 1; 15(7):2254-64. PMID: 27213235.
    View in: PubMed
  2. Premasiri WR, Lee JC, Sauer-Budge A, Théberge R, Costello CE, Ziegler LD. The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS. Anal Bioanal Chem. 2016 Jul; 408(17):4631-47. PMID: 27100230.
    View in: PubMed
  3. Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29. PMID: 27129262.
    View in: PubMed
  4. Chandler KB, Costello CE. Glycomics and glycoproteomics of membrane proteins and cell-surface receptors: Present trends and future opportunities. Electrophoresis. 2016 Jun; 37(11):1407-19. PMID: 26872045.
    View in: PubMed
  5. Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C. Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2016 Apr 5; 88(7):3440-3. PMID: 26959868.
    View in: PubMed
  6. Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016 May; 69:24-37. PMID: 26922382.
    View in: PubMed
  7. Suematsu T, Zhang L, Aphasizheva I, Monti S, Huang L, Wang Q, Costello CE, Aphasizhev R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3′ Processome to Generate Guide RNAs. Mol Cell. 2016 Feb 4; 61(3):364-78. PMID: 26833087.
    View in: PubMed
  8. Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R. Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58. PMID: 26713541.
    View in: PubMed
  9. Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85. PMID: 26729453.
    View in: PubMed
  10. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
    View in: PubMed

Complete list can be found at BU Profiles

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