• Title Research Associate Professor
  • Education B. Sc. Peking University, Beijing, China
    Ph. D. Cornell University, Ithaca, NY
  • Office 670 Albany St. 5th Floor
  • Phone 617-358-2428
  • Area of Interest FTICR MS, glycomics, proteomics, PTM characterization

Our research focuses on the development of an integrated analytical and bioinformatics approach for high-throughput de novo glycan sequencing. We utilize electron activated dissociation (ExD) methods, such as electronic excitation dissociation (EED) and negative electron transfer dissociation (NETD), to generate structurally informative tandem mass spectra, both off-line and on-line with various glycan separation methods, including high-performance liquid chromatography (HPLC) and ion mobility spectrometry (IMS) for characterization of complex glycan mixtures. We also carry out theoretical studies of the glycan ExD fragmentation processes, and collaborate with bioinformaticians to develop software tools for spectral interpretation and structural determination.

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