Understanding the complex relationship among genes, and investigating how single genes within the genome are replicated, inherited, and spatially and temporally regulated is central to both basic and translational research. Accordingly, areas of active research in the fields of Genetics and Genomics in the Department encompass a multitude of topics including developmental biology, cell biology, cancer biology, immunology, and metabolism.
Within each of these topics, investigators in the Department are currently taking advantage of classical biochemical and molecular approaches, together with cutting-edge technologies such as CRISPR/Cas editing and next-generation sequencing, to study gene regulation in multiple model organisms (nematodes, flies, fish, frogs, and mice). Many of our faculty are members of the Genome Science Insititute (GSI) which is directed by Nelson Lau and co-directed by Alla Grishok. The Department continues to expand in the areas of Genetics and Genomics and recruit additional individuals who will complement the existing strengths of our faculty, thus establishing us as a department with broad expertise in molecules, cells, and genes.
Faculty conducting research in these areas:
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Michael Blower
Professor
Mitosis, transcription, chromatin structure
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Daniel Cifuentes
Associate Professor
RNA regulation, developmental biology, virology
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Stephen R. Farmer
Professor
Growth and differentiation of cells, adipose tissue biology
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Alla Grishok
Associate Professor
Gene regulation by RNA and chromatin
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Stefan Isaac
Assistant Professor
Mitochondrial genome packaging and regulation
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Nelson C. Lau
Associate Professor
Director, Genome Science Institute (GSI)Transposable element regulation, RNAi, regulatory RNAs, gene silencing
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Matthew D. Layne
Associate Professor
Assistant Dean of ResearchMechanisms of tissue fibrosis, aortic aneurysm, and mechanotransduction
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Shawn Lyons
Assistant Professor
RNA metabolism during stress
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Valentina Perissi
Associate Professor
Co-director, Boston Nutrition Obesity Research CenterGenomic Regulation of Metabolism, Nuclear-Mitochondria Communication
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Xaralabos (Bob) Varelas
Professor
Hippo-YAP/TAZ Signaling, Lung Epithelial Biology, Cancer Biology, Tissue Regeneration and Fibrosis, Immune Cell Functions